P. Jones and A. George, The ABC transporter structure and mechanism: perspectives on recent research, Cellular and Molecular Life Sciences (CMLS), vol.61, issue.6, pp.682-699, 2004.
DOI : 10.1007/s00018-003-3336-9

A. Ponte-sucre, Availability and applications of ATP-binding cassette (ABC) transporter blockers Applied microbiology and biotechnology, pp.279-286, 2007.

J. Neumann, D. Rose-sperling, and U. Hellmich, Diverse relations between ABC transporters and lipids: An overview, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1859, issue.4, pp.605-618, 2017.
DOI : 10.1016/j.bbamem.2016.09.023

J. Bush and G. Li, Cancer chemoresistance: The relationship between p53 and multidrug transporters, International Journal of Cancer, vol.409, issue.3, pp.323-330, 2002.
DOI : 10.1038/35051606

E. Gottlieb and K. Vousden, p53 regulation of metabolic pathways. Cold Spring Harbor perspectives in biology, p.1040, 2010.

A. Puzio-kuter, The Role of p53 in Metabolic Regulation, Genes & Cancer, vol.2, issue.4, pp.385-391, 2011.
DOI : 10.1177/1947601911409738

J. Rossi, R. Rossignol, Y. Hicheri, G. Cartron, F. Bertolini et al., The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism, Oncotarget, vol.6, pp.19228-19245, 2015.

P. Muller and K. Vousden, p53 mutations in cancer, Nature Cell Biology, vol.19, issue.1, pp.2-8, 2013.
DOI : 10.1038/sj.onc.1201857

P. Muller and K. Vousden, Mutant p53 in Cancer: New Functions and Therapeutic Opportunities, Cancer Cell, vol.25, issue.3, pp.304-317, 2014.
DOI : 10.1016/j.ccr.2014.01.021

K. Chan and M. Lung, Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line, Cancer Chemotherapy and Pharmacology, vol.53, issue.6, pp.519-526, 2004.
DOI : 10.1007/s00280-004-0767-4

I. Sturm, A. Bosanquet, S. Hermann, D. Guner, B. Dorken et al., Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy, Cell Death & Differentiation, vol.20, issue.4, pp.477-484, 2003.
DOI : 10.1016/0145-2126(95)00127-1

K. Scotto, Transcriptional regulation of ABC drug transporters, Oncogene, vol.22, issue.47, pp.7496-7511, 2003.
DOI : 10.1089/dna.1996.15.105

S. Charni, G. De-bettignies, M. Rathore, J. Aguilo, P. Van-den-elsen et al., Oxidative Phosphorylation Induces De Novo Expression of the MHC Class I in Tumor Cells through the ERK5 Pathway, The Journal of Immunology, vol.185, issue.6, pp.3498-3503, 2010.
DOI : 10.4049/jimmunol.1001250

T. Gulick and M. Villalba, Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells, Int J Biochem Cell Biol, vol.53, pp.253-261, 2014.

F. Bertolini, G. Cartron, C. Lecellier, and M. Villalba, Human Leukemic Cells performing Oxidative Phosphorylation (OXPHOS) Generate an Antioxidant Response Independently of Reactive Oxygen species (ROS) Production, EBioMedicine, vol.3, pp.43-53, 2016.

M. Villalba, M. Rathore, N. Lopez-royuela, E. Krzywinska, J. Garaude et al., From tumor cell metabolism to tumor immune escape, The International Journal of Biochemistry & Cell Biology, vol.45, issue.1, pp.106-113, 2013.
DOI : 10.1016/j.biocel.2012.04.024
URL : https://hal.archives-ouvertes.fr/inserm-00726717

N. Allende-vega, Chemical metabolic inhibitors for the treatment of blood-borne cancers. Anticancer agents in medicinal chemistry, pp.223-232, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-00916461

Y. Kato, V. Kravchenko, R. Tapping, J. Han, R. Ulevitch et al., BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C, The EMBO Journal, vol.16, issue.23, pp.7054-7066, 1997.
DOI : 10.1093/emboj/16.23.7054
URL : http://emboj.embopress.org/content/embojnl/16/23/7054.full.pdf

Y. Kato, M. Zhao, A. Morikawa, T. Sugiyama, D. Chakravortty et al., Big Mitogen-activated Kinase Regulates Multiple Members of the MEF2 Protein Family, Journal of Biological Chemistry, vol.125, issue.24, pp.18534-18540, 2000.
DOI : 10.1074/jbc.270.21.12665

H. Kasler, J. Victoria, O. Duramad, and A. Winoto, ERK5 Is a Novel Type of Mitogen-Activated Protein Kinase Containing a Transcriptional Activation Domain, Molecular and Cellular Biology, vol.20, issue.22, pp.8382-8389, 2000.
DOI : 10.1128/MCB.20.22.8382-8389.2000

C. Yang, O. Ornatsky, J. Mcdermott, T. Cruz, and C. Prody, Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1, Nucleic Acids Research, vol.16, issue.23, pp.4771-4777, 1998.
DOI : 10.1093/emboj/16.23.7054

B. Ramachandran, G. Yu, and T. Gulick, Nuclear Respiratory Factor 1 Controls Myocyte Enhancer Factor 2A Transcription to Provide a Mechanism for Coordinate Expression of Respiratory Chain Subunits, Journal of Biological Chemistry, vol.112, issue.18, pp.11935-11946, 2008.
DOI : 10.1016/j.ydbio.2003.12.004

P. Stacpoole, Y. Greene, and . Dichloroacetate, Dichloroacetate, Diabetes Care, vol.15, issue.6, pp.785-791, 1992.
DOI : 10.2337/diacare.15.6.785

P. Stacpoole, The pharmacology of dichloroacetate, Metabolism, vol.38, issue.11, pp.1124-1144, 1989.
DOI : 10.1016/0026-0495(89)90051-6

E. Michelakis, L. Webster, and J. Mackey, Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer, British Journal of Cancer, vol.284, issue.7, pp.989-994, 2008.
DOI : 10.1038/35048073

L. Reitzer, B. Wice, and D. Kennell, Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells, J Biol Chem, vol.254, issue.8, pp.2669-2676, 1979.

R. Rossignol, R. Gilkerson, R. Aggeler, K. Yamagata, R. Sj et al., Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells, Cancer Research, vol.64, issue.3, pp.985-993, 2004.
DOI : 10.1158/0008-5472.CAN-03-1101

P. Stacpoole, T. Kurtz, Z. Han, and T. Langaee, Role of dichloroacetate in the treatment of genetic mitochondrial diseases???, Advanced Drug Delivery Reviews, vol.60, issue.13-14, pp.13-141478, 2008.
DOI : 10.1016/j.addr.2008.02.014

E. Michelakis, G. Sutendra, P. Dromparis, L. Webster, A. Haromy et al., Metabolic Modulation of Glioblastoma with Dichloroacetate, Science Translational Medicine, vol.462, issue.7274, pp.31-34, 2010.
DOI : 10.1038/nature08617

Y. Zhou, R. Wang, C. B. Sun, D. Hu, Y. Xu et al., Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo, International Journal of Nanomedicine, vol.11, pp.5429-5442, 2016.
DOI : 10.2147/IJN.S115037

J. Cheng and M. Haas, Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines., Molecular and Cellular Biology, vol.10, issue.10, pp.5502-5509, 1990.
DOI : 10.1128/MCB.10.10.5502

H. Broxterman, H. Pinedo, C. Kuiper, G. Schuurhuis, and J. Lankelma, Glycolysis in P-glycoprotein-overexpressing human tumor cell lines Effects of resistance-modifying agents, FEBS Letters, vol.20, issue.2, pp.405-410, 1989.
DOI : 10.1007/BF00262578

C. Staubert, H. Bhuiyan, A. Lindahl, O. Broom, Y. Zhu et al., Rewired Metabolism in Drug-resistant Leukemia Cells, Journal of Biological Chemistry, vol.61, issue.13, pp.8348-8359, 2015.
DOI : 10.1073/pnas.0711281105

J. Chen, Z. Ding, Y. Peng, F. Pan, J. Li et al., HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-glycoprotein

N. Seebacher, D. Richardson, and P. Jansson, Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics, British Journal of Pharmacology, vol.68, issue.Database Issue, pp.2557-2572, 2015.
DOI : 10.1158/0008-5472.CAN-08-1484

D. Pereira, A. Simoes, S. Gomes, R. Castro, T. Carvalho et al., MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism, Oncotarget, vol.7, issue.23, pp.34322-34340, 2016.
DOI : 10.18632/oncotarget.9107

L. Ji, H. Li, P. Gao, G. Shang, D. Zhang et al., Nrf2 Pathway Regulates Multidrug-Resistance-Associated Protein 1 in Small Cell Lung Cancer, PLoS ONE, vol.475, issue.5, pp.63404-112, 2013.
DOI : 10.1371/journal.pone.0063404.t002

X. Wang, C. Campos, J. Peart, L. Smith, J. Boni et al., Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers, Journal of Neuroscience, vol.34, issue.25, pp.8585-8593, 2014.
DOI : 10.1523/JNEUROSCI.2935-13.2014

R. Schweppe, T. Cheung, N. Ahn, L. Gibalova, M. Seres et al., Global Gene Expression Analysis of ERK5 and ERK1/2 Signaling Reveals a Role for HIF-1 in ERK5-mediated Responses, Journal of Biological Chemistry, vol.83, issue.30, pp.20993-21003159, 2006.
DOI : 10.1161/01.RES.83.3.295

J. Garaude, S. Cherni, S. Kaminski, E. Delepine, C. Chable-bessia et al., ERK5 Activates NF-??B in Leukemic T Cells and Is Essential for Their Growth In Vivo, The Journal of Immunology, vol.177, issue.11, pp.7607-7617, 2006.
DOI : 10.4049/jimmunol.177.11.7607
URL : https://hal.archives-ouvertes.fr/hal-00119762

X. Zhou, R. Chen, Z. Yu, R. Li, J. Li et al., Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation, Molecular Cancer, vol.6, issue.1, pp.63-47283, 2006.
DOI : 10.1371/journal.pone.0027222

A. Venne, S. Li, R. Mandeville, A. Kabanov, and V. Alakhov, Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells, Cancer Res, vol.56, issue.16, pp.3626-3629, 1996.

Y. T. Bryceson, S. C. Chiang, S. Darmanin, C. Fauriat, H. Schlums et al., Molecular Mechanisms of Natural Killer Cell Activation, Journal of Innate Immunity, vol.185, issue.3, pp.216-226, 2011.
DOI : 10.4049/jimmunol.1000784

V. P. Burke and J. M. Startzell, The Leukemias, Oral and Maxillofacial Surgery Clinics of North America, vol.20, issue.4, pp.597-608, 2008.
DOI : 10.1016/j.coms.2008.06.011

S. Buessow, R. Paul, and D. Lopez, Influence of mammary tumor progression on phenotype and function of spleen and in situ lymphocytes in mice, Journal of the National Cancer Institute, vol.73, issue.1, pp.249-255, 1984.

L. Cairns, Micro RNAs and cancer Ecancermedicalscience, 2010.

M. Campoli and S. Ferrone, HLA antigen and NK cell activating ligand expression in malignant cells: a story of loss or acquisition, Seminars in Immunopathology, vol.72, issue.24, pp.321-355, 2011.
DOI : 10.1111/j.1399-0039.2008.01106.x

L. Candeil, I. Gourdier, D. Peyron, N. Vezzio, V. Copois et al., ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases, International Journal of Cancer, vol.63, issue.6, pp.848-54, 2004.
DOI : 10.1016/S0167-4781(01)00270-6

J. Cao, J. Xu, W. Li, and J. Liu, Influence of selective brain cooling on the expression of ICAM-1, 2008.

S. A. Carlsen, J. E. Till, and V. Ling, Modulation of membrane drug permeability in Chinese hamster ovary cells, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.455, issue.3, pp.455-900, 1976.
DOI : 10.1016/0005-2736(76)90059-6

C. Cerboni, F. N. Nicoletta, and C. , Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity, Journal of General Virology, vol.88, issue.1, pp.242-250, 2007.
DOI : 10.1099/vir.0.82125-0

C. Cerboni, A. Z. Marco, and C. , Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis, Blood, vol.110, issue.2, pp.606-615, 2007.
DOI : 10.1182/blood-2006-10-052720

A. Cerwenka, A. Bakker, and T. Mcclanahan, Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice, Immunity, vol.12, issue.6, pp.721-727, 2000.
DOI : 10.1016/S1074-7613(00)80222-8

A. Cerwenka, J. Baron, and L. Lanier, Ectopic Expression of Retinoic Acid Early Inducible-1, 2001.

A. Cerwenka and L. Lanier, NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer, Tissue Antigens, vol.71, issue.5, pp.335-343, 2003.
DOI : 10.1038/ni799

C. Chen, Real-time quantification of microRNAs by stem-loop RT-PCR, Nucleic Acids Research, vol.33, issue.20, pp.179-179, 2005.
DOI : 10.1093/nar/gni178

Z. Chen, . Vulevic, . Ke-ile, . Soulika, and . Davis, Association of ABCA2 expression with determinants of Alzheimer's disease, The FASEB Journal, vol.18, issue.10, pp.18-1129, 2004.
DOI : 10.1096/fj.03-1490fje

J. Chen, G. Lu, J. Lin, A. Davidson, and F. Quiocho, A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle, Molecular Cell, vol.12, issue.3, pp.651-661, 2003.
DOI : 10.1016/j.molcel.2003.08.004

Z. Chen, D. Jinsheng, I. Akihiko, D. Ira, A. G. Michael et al., The Essential Vertebrate ABCE1 Protein Interacts with Eukaryotic Initiation Factors, Journal of Biological Chemistry, vol.73, issue.11, pp.281-7452, 2006.
DOI : 10.1038/sj.onc.1207549

H. Cheung, J. Du, J. Boehm, F. He, B. Weir et al., Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers, Cancer Discovery, vol.1, issue.7, pp.608-633, 2011.
DOI : 10.1158/2159-8290.CD-11-0046

J. E. Chipuk, T. Kuwana, L. Bouchier-hayes, N. Droin, D. Newmeyer et al., Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis, Science, vol.303, issue.5660, pp.1010-1014, 2004.
DOI : 10.1126/science.1092734

G. Childers, A. Eckel, J. Himmel, and . Caldwell, A new model of cystic fibrosis pathology: Lack of transport of glutathione and its thiocyanate conjugates, Med hypotheses, pp.2015-101
DOI : 10.1016/j.mehy.2006.06.020

A. Chretien, L. Roy, A. Vey, N. Prebet, T. Blaise et al., Cancer-Induced Alterations of NK-Mediated Target Recognition: Current and Investigational Pharmacological Strategies Aiming at Restoring NK-Mediated Anti-Tumor Activity, Frontiers in Immunology, vol.82, issue.1, p.122, 2014.
DOI : 10.1016/j.critrevonc.2011.04.009

H. Cho, J. Chung, S. Kim, T. Braunschweig, T. Kang et al., MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer, BMC Cancer, vol.282, issue.26, p.957, 2014.
DOI : 10.1074/jbc.M702504200

C. Classen, C. Falk, C. Friesen, S. Fulda, I. Herr et al., Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression, Haematologica, vol.88, pp.509-521, 2003.

P. Codo, M. Weller, G. Meister, E. Szabo, A. Steinle et al., MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape, Oncotarget, vol.5, issue.17, pp.7651-7662, 2014.
DOI : 10.18632/oncotarget.2287

F. Consoli, G. Arcangeli, V. Ferrari, S. Grisanti, C. Almici et al., Circulating Tumor Cells and Cardiac Metastasis from Esophageal Cancer: A Case Report, Case Reports in Oncology, vol.4, issue.2, pp.299-303, 2011.
DOI : 10.1159/000329021

M. A. Cooper, T. A. Fehniger, and M. A. Caligiuri, The biology of human natural killer-cell subsets, Trends in Immunology, vol.22, issue.11, pp.633-673, 2001.
DOI : 10.1016/S1471-4906(01)02060-9

T. A. Fehniger, S. F. Cai, X. Cao, A. J. Bredemeyer, R. M. Presti et al., Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-existing Pool of??Granzyme B and Perforin mRNAs, Immunity, vol.26, issue.6, pp.798-811, 2007.
DOI : 10.1016/j.immuni.2007.04.010

T. A. Fehniger, T. Wylie, E. Germino, J. W. Leong, V. J. Magrini et al., Next-generation sequencing identifies the natural killer cell microRNA transcriptome, Genome Research, vol.20, issue.11, pp.1590-1604, 2010.
DOI : 10.1101/gr.107995.110

L. Fernández-messina, O. Ashiru, S. Agüera-gonzález, H. T. Reyburn, and M. Valés-gómez, The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells, Journal of Cell Science, vol.124, issue.3, pp.321-327, 2011.
DOI : 10.1242/jcs.076042

B. Feuerecker, S. Pirsig, C. Seidl, M. Aichler, A. Feuchtinger et al., Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo, Cancer Biology & Therapy, vol.284, issue.14, pp.1425-1435, 2012.
DOI : 10.1002/jcp.20494

W. Fiebiger, U. Olszewski, E. Ulsperger, K. Geissler, H. et al., In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines, Clinical and Translational Oncology, vol.245, issue.1, 2011.
DOI : 10.1016/j.tox.2007.12.010

O. Filipe-santos, J. Bustamante, A. Chapgier, G. Vogt, L. De-beaucoudrey et al., Inborn errors of IL-12/23-and IFN-gamma-mediated immunity: molecular, cellular, and clinical features, Semin Immunol, 2006.

R. Flavin, G. Zadra, and M. Loda, Metabolic alterations and targeted therapies in prostate cancer, The Journal of Pathology, vol.53, issue.2, 2011.
DOI : 10.1016/j.cpet.2009.05.001

A. Fojo, M. Cornwell, C. Cardarelli, D. Clark, N. Richert et al., Molecular biology of drug resistance, Breast Cancer Research and Treatment, vol.84, issue.1, pp.5-16, 1987.
DOI : 10.1128/MCB.6.5.1671

G. Freud, J. Yu, and M. A. Caligiuri, Human natural killer cell development in secondary lymphoid tissues, Seminars in Immunology, vol.26, issue.2, pp.132-137, 2014.
DOI : 10.1016/j.smim.2014.02.008

Z. Fu and D. Tindall, FOXOs, cancer and regulation of apoptosis, Oncogene, vol.1, issue.16, pp.2312-2319, 2008.
DOI : 10.1074/jbc.M205424200

S. Fujiwara, Y. Kawano, Y. H. Okuno, Y. Nosaka, K. Mitsuya et al., PDK1 inhibition is a novel therapeutic target in multiple myeloma, British Journal of Cancer, vol.48, pp.170-178, 2013.
DOI : 10.1053/j.seminhematol.2010.11.003

L. Galluzzi, A. Buqué, O. Kepp, L. Zitvogel, and G. Kroemer, Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. Cancer Cell, Dec, vol.1428, issue.6, pp.690-714, 2015.

M. Gameiro, R. Silva, C. Rocha-pereira, H. Carmo, F. Carvalho et al., Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP. Molecules, 2017.

F. Gerosa, B. Baldani-guerra, L. Lyakh, G. Batoni, S. Esin et al., Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells, The Journal of Experimental Medicine, vol.155, issue.6, pp.1447-61, 2008.
DOI : 10.1042/bj1510351

F. Gerosa, A. Gobbi, P. Zorzi, S. Burg, F. Briere et al., The Reciprocal Interaction of NK Cells with Plasmacytoid or Myeloid Dendritic Cells Profoundly Affects Innate Resistance Functions, The Journal of Immunology, vol.174, issue.2, pp.727-761, 2005.
DOI : 10.4049/jimmunol.174.2.727

F. Ghiringhelli, C. Ménard, M. Terme, C. Flament, J. Taieb et al., regulatory T cells inhibit natural killer cell functions in a transforming growth factor????????dependent manner, The Journal of Experimental Medicine, vol.9, issue.8, pp.1075-1085, 2005.
DOI : 10.4049/jimmunol.172.10.5957
URL : https://hal.archives-ouvertes.fr/pasteur-00020140

S. Gilfillan, E. L. Ho, C. Marina, W. M. Yokoyama, and M. C. , NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation, Nature Immunology, vol.162, issue.12, pp.1150-1155, 2002.
DOI : 10.1002/1521-4141(200104)31:4<1076::AID-IMMU1076>3.0.CO;2-Y

S. Gilfillan, E. L. Ho, C. Marina, W. M. Yokoyama, and C. Marco, NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation, Nature Immunology, vol.162, issue.12, pp.1150-1155, 2002.
DOI : 10.1002/1521-4141(200104)31:4<1076::AID-IMMU1076>3.0.CO;2-Y

V. Gogvadze, B. Zhinvotovsky, and S. Orrenius, The Warburg effect and mitochondrial stability in cancer cells, Molecular Aspects of Medicine, vol.31, issue.1, pp.60-74, 2010.
DOI : 10.1016/j.mam.2009.12.004

J. Gordan, C. B. Thompson, and S. M. , HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation, Cancer Cell, vol.12, issue.2, pp.108-113, 2007.
DOI : 10.1016/j.ccr.2007.07.006

M. Gottesman, C. Hrycyna, P. Schoenlein, U. Germann, and I. Pastan, Genetic Analysis of the Multidrug Transporter, Annual Review of Genetics, vol.29, issue.1, pp.607-649, 1995.
DOI : 10.1146/annurev.ge.29.120195.003135

M. Gottesman and S. Ambudkar, Overview: ABC Transporters and Human Disease, Journal of Bioenergetics and Biomembranes, vol.33, issue.6, pp.453-458, 2001.
DOI : 10.1023/A:1012866803188

G. Sutendra and E. , Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology, Frontiers in Oncology, vol.3, p.7, 2013.
DOI : 10.3389/fonc.2013.00038

G. E. Conner, C. Wijkstrom-frei, S. H. Randell, V. E. Fernandez, and M. Salathe, The lactoperoxidase system links anion transport to host defense in cystic fibrosis, FEBS Letters, vol.175, issue.2, pp.23-271, 2007.
DOI : 10.1165/rcmb.2005-0059OC

V. Groh, S. Bahram, and . Bauer, Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium., Proceedings of the National Academy of Sciences, vol.93, issue.22, pp.12445-12450, 1996.
DOI : 10.1073/pnas.93.22.12445

V. Groh, A. Bruhl, H. El-gabalawy, J. L. Nelson, and T. S. , Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis, Proceedings of the National Academy of Sciences, vol.160, issue.5, pp.9452-9457, 2003.
DOI : 10.1016/S0002-9440(10)61118-2

V. Groh, J. Wu, C. Yee, and T. Spies, Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation, Nature, vol.17, issue.6908, pp.734-738, 2002.
DOI : 10.1126/science.285.5428.730

N. Guerra, X. Ying, and N. T. Joncker, NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy, Immunity, vol.28, issue.4, pp.571-580, 2008.
DOI : 10.1016/j.immuni.2008.02.016

E. Hahm, A. I. Karlsson, M. Y. Bonner, J. L. Arbiser, and S. V. Singh, Honokiol inhibits androgen receptor activity in prostate cancer cells, The Prostate, vol.28, issue.6, pp.408-420, 2014.
DOI : 10.1016/S0090-4295(02)02006-X

E. Hahm, K. Sakao, and S. Singh, Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells, The Prostate, vol.118, issue.8, pp.1209-1230, 2014.
DOI : 10.1002/cncr.26434

D. Hanahan and R. A. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-674, 2011.
DOI : 10.1016/j.cell.2011.02.013

B. S. Hanberry, R. Berger, and J. A. Zastre, High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate, Cancer Chemotherapy and Pharmacology, vol.8, issue.7, pp.585-594, 2014.
DOI : 10.1038/nrd2803

B. Hanberry, R. Berger, and J. Zastre, High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate, Cancer Chemotherapy and Pharmacology, vol.8, issue.7, pp.585-94, 2014.
DOI : 10.1038/nrd2803

D. Han, V. Rodriguez-bravo, E. Charytonowicz, E. Demicco, J. Domingo-domenech et al., Targeting sarcoma tumor-initiating cells through differentiation therapy, Stem Cell Research, vol.21, pp.117-123, 2017.
DOI : 10.1016/j.scr.2017.04.004

E. Harlow, N. Williamson, R. Ralston, D. Helfman, and T. Adams, Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53., Molecular and Cellular Biology, vol.5, issue.7, pp.1601-1611, 1985.
DOI : 10.1128/MCB.5.7.1601

A. Haugrud, Y. Zhuang, J. Coppock, and W. Miskimins, Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells, Breast Cancer Research and Treatment, vol.346, issue.3, 2014.
DOI : 10.1016/j.canlet.2014.01.015

S. A. Hawley, J. Boudeau, J. L. Reid, K. J. Mustard, L. Udd et al., Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade, Journal of Biology, vol.2, issue.4, p.28, 2003.
DOI : 10.1186/1475-4924-2-28

M. He, J. Rosen, D. Mangiameli, and S. K. Libutti, Cancer Development and Progression, Adv. Exp.Med. Biol, vol.593, pp.117-133, 2007.
DOI : 10.1007/978-0-387-39978-2_12

A. Heinemann, F. Zhao, S. Pechlivanis, J. Eberle, A. Steinle et al., Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D, Cancer Research, vol.72, issue.2, pp.460-7110, 2012.
DOI : 10.1158/0008-5472.CAN-11-1977

H. Hengartner, Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice, Nature, vol.369, pp.31-37, 1994.

C. F. Higgins, ABC Transporters: From Microorganisms to Man, Annual Review of Cell Biology, vol.8, issue.1, pp.67-113, 1992.
DOI : 10.1146/annurev.cb.08.110192.000435

C. Higgins and K. Linton, The ATP switch model for ABC transporters, Nature Structural & Molecular Biology, vol.173, issue.10, 2004.
DOI : 10.1128/jb.173.4.1444-1451.1991

B. Kaur, F. W. Severson, E. A. Matheny, S. Brat, D. et al., Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis, Neuro-Oncology, vol.7, issue.2, pp.134-153, 2005.
DOI : 10.1016/S0167-0115(03)00037-5

K. Kawauchi, K. Araki, and K. Tobiume, p53 regulates glucose metabolism through an IKK-NF-??B pathway and inhibits cell transformation, Nature Cell Biology, vol.35, issue.5, pp.611-618, 2008.
DOI : 10.1016/S1074-7613(00)00053-4

J. Kieckbusch, L. Gaynor, A. Moffett, and F. Colucci, Corrigendum: MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodeling, Nature Communications, vol.8, 2017.
DOI : 10.1038/ncomms15444

J. W. Kim, I. Tchemyshyov, G. Semenza, and C. Dang, HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia, Cell Metabolism, vol.3, issue.3, pp.177-185, 2006.
DOI : 10.1016/j.cmet.2006.02.002

C. Klein, I. Waldhauer, V. Nicolini, A. Freimoser-grundschober, T. Nayak et al., Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines, OncoImmunology, vol.126, issue.15, pp.1277306-1277316, 1080.
DOI : 10.1182/blood-2008-05-160747

W. Klimecki, B. Futscher, T. Grogan, and W. Dalton, P-glycoprotein expression and function in circulating blood cells from normal volunteers, Blood. May, vol.183, issue.9, pp.2451-2459, 1994.

J. Kluza, P. Corazao-rozas, Y. Touil, M. Jendoubi, C. Maire et al., Inactivation of the HIF-1??/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants, Cancer Research, vol.72, issue.19, pp.5035-5047, 2012.
DOI : 10.1158/0008-5472.CAN-12-0979

M. Kloss, P. Decker, K. Baltz, T. Baessler, G. Jung et al., Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA, The Journal of Immunology, vol.181, issue.10, 1950.
DOI : 10.4049/jimmunol.181.10.6711

A. Knudson and . Jr, My memories of Dr. Giovanni Neri, American Journal of Medical Genetics Part A, vol.161, issue.11, 2013.
DOI : 10.1002/ajmg.a.36268

G. Kroemer and J. Pouyssegur, Tumor cell metabolism:cancer's achilles hell.Cancer cell, pp.472-782, 2008.
DOI : 10.1016/j.ccr.2008.05.005
URL : https://doi.org/10.1016/j.ccr.2008.05.005

P. Krishnamurthy and J. Schuetz, ROLE OF ABCG2/BCRP IN BIOLOGY AND MEDICINE, Annual Review of Pharmacology and Toxicology, vol.46, issue.1, pp.381-410, 2006.
DOI : 10.1146/annurev.pharmtox.46.120604.141238

P. Kruse, J. Matta, S. Ugolini, and E. Vivier, Natural cytotoxicity receptors and their ligands, Immunology and Cell Biology, vol.4, issue.3, 2014.
DOI : 10.3389/fimmu.2013.00069

E. Kruijf, A. Sajet, J. Van-nes, H. Putter, V. Smit et al., NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study, BMC Cancer, vol.419, issue.1, p.24, 2012.
DOI : 10.1038/nature01112

A. Kumar, S. Kant, and S. M. Singh, Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation, Chemico-Biological Interactions, vol.199, issue.1, pp.29-37, 2012.
DOI : 10.1016/j.cbi.2012.06.005

A. Kumar, S. Kant, and S. M. Singh, Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation, Toxicology and Applied Pharmacology, vol.273, issue.1, pp.196-208, 2013.
DOI : 10.1016/j.taap.2013.09.005

K. Kumar, S. Wigfield, H. E. Gee, C. M. Devlin, D. Singleton et al., Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts, Journal of Molecular Medicine, vol.54, issue.6, pp.749-758, 2013.
DOI : 10.1021/jm200892s

M. Kusumi, T. Yamashita, T. Fujii, T. Nagamatsu, S. Kozuma et al., Expression patterns of lectin-like natural killer receptors, inhibitory CD94/NKG2A, and activating CD94/NKG2C on decidual CD56bright natural killer cells differ from those on peripheral CD56dim natural killer cells, Journal of Reproductive Immunology, vol.70, issue.1-2, pp.33-42, 2006.
DOI : 10.1016/j.jri.2005.12.008

M. Kwitniewski, J. Moan, and A. Juzeniene, Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy, Photochem. Photobiol. Sci., vol.2, issue.1, pp.25-28, 2011.
DOI : 10.1016/j.placenta.2004.07.002

D. Lane and C. L. , T antigen is bound to a host protein in SV40-transformed cells, Nature. Mar, vol.15278, issue.5701, pp.261-264, 1979.

. Lanier, Natural killer cells, viruses and cancer Adelheid Cerwenka & Lewis L, Nature Reviews Immunology, vol.1, pp.41-4910, 2001.

L. Lanier, C. Chang, M. Azuma, J. Ruitenberg, J. Hemperly et al., Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56), J. Immunol. Baltim. Md, vol.146, pp.4421-4426, 1950.

M. Lanotte, V. Martin-thouvenin, S. Najman, P. Balerini, F. Valensi et al., NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3), Blood. Mar, vol.177, issue.5, pp.1080-1086, 1991.

A. Lasry and Y. Ben-neriah, Senescence-associated inflammatory responses: aging and cancer perspectives, Trends in Immunology, vol.36, issue.4, pp.217-228, 2015.
DOI : 10.1016/j.it.2015.02.009

P. Lechat, Médicaments utilisés en chimiothérapie anticancéreuse, 2006.

L. Disponibledugarin and P. Vennin, Comprendre la chimiothérapie, Institut National du Cancer (INCa), vol.127, 2011.

B. Lerner, Complicated lessons: Lorenzo Odone and medical miraclesGene expression profiling of paired ovarian tumors obtained prior to and following adjuvant chemotherapy: molecular signatures of chemoresistant tumors, Lancet Int J Oncol, vol.73, issue.291, pp.5-24, 2006.

H. Li, T. Lakshmikanth, C. Garofalo, M. Enge, C. Spinnler et al., Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2, Cell Cycle, vol.10, issue.19, pp.3346-5810, 2011.
DOI : 10.4161/cc.10.19.17630

H. W. Li and M. Sykes, Emerging concepts in haematopoietic cell transplantation, Nature Reviews Immunology, vol.110, issue.6, pp.403-416, 2012.
DOI : 10.1182/blood-2007-02-072405

K. Li, M. Mandai, J. Hamanishi, N. Matsumura, A. Suzuki et al., Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis, Cancer Immunology, Immunotherapy, vol.175, issue.Pt9, pp.641-652, 2009.
DOI : 10.4049/jimmunol.175.2.720

G. Lin, D. K. Hill, G. Andrejeva, J. K. Boult, H. Troy et al., Dichloroacetate induces autophagy in colorectal cancer cells and tumours, Dichloroacetate induces autophagy in colorectal cancer cells and tumours, pp.375-385, 2014.
DOI : 10.1126/science.290.5493.989

K. Linton and C. Higgins, Structure and function of ABC transporters: the ATP switch provides flexible control, Pfl??gers Archiv - European Journal of Physiology, vol.121, issue.5, pp.555-67, 2006.
DOI : 10.1085/jgp.20028673

D. Linzer, W. Maltzman, and A. Levine, The SV40 a gene product is required for the production of a 54,000 MW cellular tumor antigen, Virology, vol.98, issue.2, pp.308-326, 1979.
DOI : 10.1016/0042-6822(79)90554-3

H. Liu, E. S. Rich, L. Godley, O. Odenike, L. Joseph et al., Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions, Blood, vol.118, issue.24, pp.6438-6445, 2011.
DOI : 10.1182/blood-2011-08-372508

C. Liu, S. Yu, J. Kappes, J. Wang, W. Grizzle et al., Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host, Blood, vol.109, issue.10, pp.1094336-4342, 2007.
DOI : 10.1182/blood-2006-09-046201

W. Liu, J. Su, J. Jiang, X. Li, Q. Ye et al., Identification of microRNA transcriptome involved in human natural killer cell activation, Immunology Letters, vol.143, issue.2, pp.208-217, 2012.
DOI : 10.1016/j.imlet.2012.02.014

P. Livingston, S. Zhang, S. Adluri, T. Yao, L. Graeber et al., Tumor cell reactivity mediated by IgM antibodies in sera from melanoma patients vaccinated with GM2 ganglioside covalently linked to KLH is increased by IgG antibodies. Cancer immunology, immunotherapy : CeII1997 Prospects for the use of NK cells in immunotherapy of human cancer, Nat. Rev. Immunol, vol.43, issue.7, pp.324-330, 2006.

C. Higgins, Multiple molecular mechanisms for multidrug resistance transporters NKG2D- mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules, J Exp Med, vol.197, issue.10, pp.1245-53, 2003.

T. Loo, M. Bartlett, and D. Clarke, Rescue of Folding Defects in ABC Transporters Using Pharmacological Chaperones, Journal of Bioenergetics and Biomembranes, vol.274, issue.6, pp.501-508, 2005.
DOI : 10.1007/s10863-005-9499-3

J. Lu, D. Manjusri, and K. Suman, Induction of ATM/ATR pathway combined with V??2V??2 T cells enhances cytotoxicity of ovarian cancer cells, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1842, issue.7, pp.1071-1079, 2014.
DOI : 10.1016/j.bbadis.2014.04.003

J. Lum, D. Schnepple, Z. Nie, J. Sanchez-dardon, G. Mbisa et al., Differential Effects of Interleukin-7 and Interleukin-15 on NK Cell Anti-Human Immunodeficiency Virus Activity, Journal of Virology, vol.78, issue.11, pp.6033-6075, 2004.
DOI : 10.1128/JVI.78.11.6033-6042.2004

L. Luo, L. Zhengyu, and W. Weidong, Role of MICA antibodies in solid organ transplantation, Clinical Transplantation, vol.21, issue.3 Suppl, 2014.
DOI : 10.1111/ctr.12295

S. Mace, ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease, Neurobiology of Disease, vol.18, issue.1, pp.119-144, 2005.
DOI : 10.1016/j.nbd.2004.09.011

Z. Madjd, I. Spendlove, R. Moss, S. Bevin, S. Pinder et al., Upregulation of MICA on high-grade invasive operable breast carcinoma, Cancer Immun, 2007.

B. Madhok, S. Yeluri, S. Perry, T. Hughes, and J. D. , Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells, British Journal of Cancer, vol.134, issue.12, pp.1746-52, 2010.
DOI : 10.1007/s00432-009-0590-8

S. Maher, P. Sipos, S. Maher, R. Szabóné, and I. Eros, Liberation of active substance from pharmaceutical suspensions I. Effect of surfactants on the active substance dissolving, Acta Pharm Hung, vol.77, issue.2, pp.142-151, 2007.

J. Mallinson, D. Constantin-teodosiu, P. Glaves, E. Martin, W. Davies et al., Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents, The Journal of Physiology, vol.6, issue.24, pp.6389-402, 2012.
DOI : 10.1016/j.cmet.2007.11.004

S. Matoba, p53 Regulates Mitochondrial Respiration, Science, vol.312, issue.5780, pp.1650-1653, 2006.
DOI : 10.1126/science.1126863

S. Mathupala, C. Heese, and P. Pedersen, Glucose Catabolism in Cancer Cells, Journal of Biological Chemistry, vol.44, issue.36, pp.22776-22780, 1997.
DOI : 10.1007/978-3-662-22275-1

E. D. Michelakis, G. Sutendra, P. Dromparis, L. Webster, A. Haromy et al., Metabolic Modulation of Glioblastoma with Dichloroacetate, Science Translational Medicine, vol.462, issue.7274, pp.31-34, 2010.
DOI : 10.1038/nature08617

E. D. Michelakis, L. Webster, and J. R. Mackey, Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer, British Journal of Cancer, vol.284, issue.7, pp.989-994, 2008.
DOI : 10.1038/35048073

R. Misbin, Effects of Dichloroacetate on Lipid Metabolism in Isolated Rat Liver Cells, Diabetes, vol.28, issue.4, pp.265-71, 1979.
DOI : 10.2337/diab.28.4.265

J. Morère, T. Bouillet, and M. Crépin, Le cancer pour les nuls, Paris: First éd, vol.295, 2011.

M. Morita, K. Motoki, K. Akimoto, T. Natori, T. Sakai et al., Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice, Journal of Medicinal Chemistry, vol.38, issue.12, pp.382176-2187, 1995.
DOI : 10.1021/jm00012a018

P. A. Muller and K. H. Vousden, p53 mutations in cancer, Nature Cell Biology, vol.19, issue.1, pp.2-8, 2013.
DOI : 10.1038/sj.onc.1201857

M. Morfouace, L. Lalier, M. Bahut, V. Bonnamain, P. Naveilhan et al., Comparison of Spheroids Formed by Rat Glioma Stem Cells and Neural Stem Cells Reveals Differences in Glucose Metabolism and Promising Therapeutic Applications, Journal of Biological Chemistry, vol.38, issue.40, pp.33664-33674, 2012.
DOI : 10.1002/ijc.26173

. Mo, A. Zhang, N. Zhou, J. Huang, Q. Liu et al., The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage, Cell Res, 2013.

M. Luciana, L. , M. B. , M. Victoria, and G. , NF-Kappa B Regulates Expression of the MHC Class I-Related Chain A Gene in Activated T Lymphocytes, Journal of Immunology, vol.173, issue.9, pp.5583-5590, 1950.

L. Molinero, C. I. Lorena, M. Domaica, and F. Beatriz, Intracellular Expression of MICA in Activated CD4 T Lymphocytes and Protection from NK Cell-Mediated MICA-Dependent Cytotoxicity, Human Immunology, vol.67, issue.3, pp.170-182, 2006.
DOI : 10.1016/j.humimm.2006.02.010

E. Montaldo, G. D. Zotto, M. D. Chiesa, M. C. Mingari, A. Moretta et al., Human NK cell receptors/markers: A tool to analyze NK cell development, subsets and function, Cytometry Part A, vol.21, issue.1, pp.702-713, 2013.
DOI : 10.1093/intimm/dxp046
URL : http://onlinelibrary.wiley.com/doi/10.1002/cyto.a.22302/pdf

J. Mosser, Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters, Nature, vol.361, issue.6414, pp.726-756, 1993.
DOI : 10.1038/361726a0

S. Munich, A. Sobo-vujanovic, J. Buchser, D. Beer-stolz, and N. Vujanovic, Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands, OncoImmunology, vol.1, issue.7, pp.1074-1083, 2012.
DOI : 10.1385/IR:36:1:247
URL : http://www.tandfonline.com/doi/pdf/10.4161/onci.20897?needAccess=true

R. Nakagawa, I. Serizawa, K. Motoki, M. Sato, H. Ueno et al., Antitumor Activity of ??-Galactosylceramide, KRN7000, in Mice With the Melanoma B16 Hepatic Metastasis and Immunohistological Study of Tumor Infiltrating Cells, Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, vol.12, issue.2, pp.51-58, 2000.
DOI : 10.3727/096504001108747521

K. Nakamura, M. Nakayama, and M. Kawano, Fratricide of natural killer cells dressed with tumor-derived NKG2D ligand, Proceedings of the National Academy of Sciences, vol.110, issue.23, pp.9421-9426, 2013.
DOI : 10.1038/ni1236

N. Nausch, I. Galani, E. Schlecker, and A. Cerwenka, Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells, Blood, vol.112, issue.10, pp.4080-4089, 2008.
DOI : 10.1182/blood-2008-03-143776
URL : http://www.bloodjournal.org/content/bloodjournal/112/10/4080.full.pdf

K. Nakano and K. Vousden, PUMA, a Novel Proapoptotic Gene, Is Induced by p53, Molecular Cell, vol.7, issue.3, pp.683-694, 2001.
DOI : 10.1016/S1097-2765(01)00214-3

S. Nedvetzki, S. S. , and R. A. Eagle, Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses, Blood, vol.109, issue.9, pp.3776-3785, 2007.
DOI : 10.1182/blood-2006-10-052977
URL : https://hal.archives-ouvertes.fr/hal-00165508

S. Nedvetzki, S. Sowinski, R. Eagle, J. Harris, F. Vély et al., Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses, Blood, vol.109, issue.9, 2007.
DOI : 10.1182/blood-2006-10-052977
URL : https://hal.archives-ouvertes.fr/hal-00165508

K. Nguyen, T. Salazar-mather, M. Dalod, J. Van-deusen, X. Wei et al., Coordinated and Distinct Roles for IFN-????, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection, The Journal of Immunology, vol.169, issue.8, pp.4279-87, 2002.
DOI : 10.4049/jimmunol.169.8.4279

M. R. Niewisch, Z. Kuçi, H. Wolburg, M. Sautter, L. Krampen et al., Influence of Dichloroacetate (DCA) on Lactate Production and Oxygen Consumption in Neuroblastoma Cells: Is DCA a Suitable Drug for Neuroblastoma Therapy?, Cellular Physiology and Biochemistry, vol.29, issue.3-4, pp.373-380, 2012.
DOI : 10.1159/000338492

A. Nitahara, S. Hideki, and A. I. , NKG2D Ligation without T Cell Receptor Engagement Triggers Both Cytotoxicity and Cytokine Production in Dendritic Epidermal T Cells, Journal of Investigative Dermatology, vol.126, issue.5, pp.1052-1058, 2006.
DOI : 10.1038/sj.jid.5700112

K. Ogasawara, J. A. Hamerman, R. Lauren, and . Ehrlich, NKG2D Blockade Prevents Autoimmune Diabetes in NOD Mice, Immunity, vol.20, issue.6, pp.757-767, 2004.
DOI : 10.1016/j.immuni.2004.05.008

J. S. Orange, E. Narayanaswamy-ramesh, and . Remold-o-'donnell, Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses, Proceedings of the National Academy of Sciences, vol.104, issue.1, pp.11351-11356, 2002.
DOI : 10.1007/PL00008395

. Orange, NKp30 Ligation Induces Rapid Activation of the Canonical NF-kappaB Pathway in NK Cells, Journal of Immunology, vol.179, issue.11, pp.7385-7396, 1950.

P. Ballez and M. , Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease, Gastroenterology, vol.141, issue.226, pp.217-243, 2011.

J. M. Park, L. D. Recht, S. Josan, M. Merchant, T. Jang et al., Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging, Neuro-Oncology, vol.206, issue.2, pp.433-441, 2013.
DOI : 10.1016/j.jmr.2010.07.006

D. Pende, R. Castriconi, P. Romagnani, G. M. Spaggiari, S. Marcenaro et al., Expression of the DNAM-1, 2006.

M. Peraldi, J. Berrou, N. Dulphy, A. Seidowsky, P. Haas et al., Oxidative Stress Mediates a Reduced Expression of the Activating Receptor NKG2D in NK Cells from End-Stage Renal Disease Patients, The Journal of Immunology, vol.182, issue.3, pp.1696-705, 2009.
DOI : 10.4049/jimmunol.182.3.1696

S. Pierre, A. Bats, and X. Coumoul, Understanding SOS (Son of Sevenless), Biochemical Pharmacology, vol.82, issue.9, pp.1049-1056, 2011.
DOI : 10.1016/j.bcp.2011.07.072

. Recommandations-en-oncourologie, Tumeurs urothéliales, Prog Urol, vol.20, pp.255-74, 2010.

A. Poli, T. Michel, M. Thérésine, E. Andrès, F. Hentges et al., natural killer (NK) cells: an important NK cell subset, Immunology, vol.7, issue.4, pp.458-465, 2009.
DOI : 10.4049/jimmunol.174.9.5187
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2008.03027.x/pdf

M. Raab, K. Podar, I. Breitkreutz, P. Richardson, and K. Anderson, Multiple myeloma, Multiple myeloma, pp.324-339, 2009.
DOI : 10.1016/S0140-6736(09)60221-X
URL : https://hal.archives-ouvertes.fr/inserm-00130206

B. Rabinovich, R. Ketchem, M. Wolfson, L. Goldstein, M. Skelly et al., A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing, Immunology and Cell Biology, vol.296, issue.6, 2008.
DOI : 10.1126/science.1069639

M. Radosavljevic, C. Benoît, and M. J. Wilson, A Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2???q25.3, Genomics, vol.79, issue.1, pp.114-123, 2002.
DOI : 10.1006/geno.2001.6673

M. Randazzo, P. Terness, G. Opelz, and C. Kleist, Active-specific immunotherapy of human cancers with the heat shock protein Gp96-revisited, International Journal of Cancer, vol.11, issue.Pt 13, pp.2219-2250, 2012.
DOI : 10.1158/1078-0432.CCR-05-1553

D. Raulet, Bone Marrow Cell Rejection, MHC, NK Cells, and Missing Self Recognition: Ain???t That Peculiar (with Apologies to Marvin Gaye), The Journal of Immunology, vol.195, issue.7, pp.2923-2928, 2015.
DOI : 10.4049/jimmunol.1501804

J. R. Riordan, Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines, Nature, vol.305, issue.6031, pp.316-817, 1985.
DOI : 10.1128/MCB.3.9.1634

C. A. Ritter, Cellular Export of Drugs and Signaling Molecules by the ATP-binding Cassette Transporters MRP4 (ABCC4) and MRP5 (ABCC5), Drug Metabolism Reviews, vol.23, issue.1, pp.253-78, 2005.
DOI : 10.1042/bj20021886

T. Roger, A. Schneider, M. Weier, F. Sweep, L. Roy et al., High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates, Proceedings of the National Academy of Sciences, vol.2012, issue.6, pp.997-1005, 2016.
DOI : 10.1016/j.bbamcr.2009.09.007

I. F. Robey, M. , and N. K. , Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer, BMC Cancer, vol.2, issue.3, 2011.
DOI : 10.1016/S0006-3495(04)74099-0

S. Rust, Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1, Nature Genetics, vol.22, issue.4, pp.352-357, 1999.
DOI : 10.1038/11921

A. Sablina, A. Budanov, G. Ilyinskaya, L. Agapova, J. Kravchenko et al., The antioxidant function of the p53 tumor suppressor, Nature Medicine, vol.56, issue.12, pp.1306-1319, 2005.
DOI : 10.1038/nature01819

S. Shafi, An NKG2D-Mediated Human Lymphoid Stress Surveillance Response with High Interindividual Variation, Science Translational Medicine, vol.6, issue.9, pp.113-124, 2011.
DOI : 10.1038/ni1239
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966512/pdf

R. Salama, M. Sadaie, M. Hoare, and M. Narita, Cellular senescence and its effector programs, Genes & Development, vol.28, issue.2, pp.99-114, 2014.
DOI : 10.1101/gad.235184.113
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909793/pdf

W. Y. Sanchez, S. L. Mcgee, T. Connor, B. Mottram, A. Wilkinson et al., Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib, British Journal of Cancer, vol.23, issue.8, pp.1624-1633, 2013.
DOI : 10.1007/s00432-010-0875-y

S. Ho-ra, A Case of Sustained Cholestasis Caused by Acute A Viral Hepatitis in Dubin-Johnson Syndrome, The Korean Journal of Gastroenterology, vol.59, issue.4, pp.313-316, 2012.
DOI : 10.4166/kjg.2012.59.4.313

S. Altmeyer, J. Zentek, W. Vahjen, and L. Scharek-tedin, The expression of NKG2D on porcine IEL and its possible relation to the adaptive intestinal immune system, Veterinary Immunology and Immunopathology, vol.187, pp.8-8749, 2017.
DOI : 10.1016/j.vetimm.2017.03.005

T. Schatton and M. Frank, REVIEW ARTICLE: Cancer stem cells and human malignant melanoma, Pigment Cell & Melanoma Research, vol.126, issue.1, pp.39-55, 2008.
DOI : 10.4049/jimmunol.173.2.1444
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2007.00427.x/pdf

R. Schreiber, L. Old, and M. Smyth, Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion, Science, vol.144, issue.5, pp.3311565-1570, 2011.
DOI : 10.1016/j.cell.2011.02.013

S. Schrambach, A. Marc, L. Vincent, S. Jean, and B. Seiamak, In Vivo Expression Pattern of MICA and MICB and Its Relevance to Auto-Immunity and Cancer, PLoS ONE, vol.43, issue.6, p.518, 2007.
DOI : 10.1371/journal.pone.0000518.t001

A. Schreiber, J. Norbury, D. Sousa, and E. , Functional recovery of untreated human immunodeficiency virus-associated Guillain-Barr?? syndrome: A case report, Annals of Physical and Rehabilitation Medicine, vol.54, issue.8, 2011.
DOI : 10.1016/j.rehab.2011.09.009

M. M. Schuierer and T. Langmann, Molecular diagnosis of ATP-binding cassette transporter-related diseases, Expert Review of Molecular Diagnostics, vol.359, issue.5, pp.755-67, 2005.
DOI : 10.4161/cbt.2.6.557

U. Schulz, M. Kreutz, G. Multhoff, B. Stoelcker, M. Köhler et al., Interleukin-10 Promotes NK Cell Killing of Autologous Macrophages by Stimulating Expression of NKG2D Ligands, Scandinavian Journal of Immunology, vol.107, issue.4, pp.319-350, 2010.
DOI : 10.1097/00042560-199611010-00002

B. Schulze, D. Piehler, M. Eschke, L. Heyen, M. Protschka et al., Therapeutic expansion of CD4+FoxP3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection. Pathog Dis, 2016.

F. Schwartzenberg-bar-yoseph, Gene Expression, Cancer Research, vol.64, issue.7, pp.2627-633, 2004.
DOI : 10.1158/0008-5472.CAN-03-0846

N. Schwinn, V. Daria, and S. Antje, Interferon-?? down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells, International Journal of Cancer, vol.172, issue.7, pp.1594-1604, 2009.
DOI : 10.4049/jimmunol.172.12.7335

D. Scott and J. Davidson, Managing Chronic Kidney Disease in Type 2 Diabetes in Family Practice, Journal of the National Medical Association, vol.103, issue.9-10, pp.9-10952, 2011.
DOI : 10.1016/S0027-9684(15)30452-1

S. Scoville, A. Freud, and M. Caligiuri, Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells. Front Immunol, 2017.

G. Semenza, HIF-1: upstream and downstream of cancer metabolism, Current Opinion in Genetics & Development, vol.20, issue.1, pp.51-56, 2010.
DOI : 10.1016/j.gde.2009.10.009

S. Sergey, M. Lawrence, M. D. Nogee, T. Annilo, E. Dsan et al., ABCA3 gene mutations in newborns with fatal surfactant deficiency, N Engl J Med, issue.13, pp.350-1296, 2004.

L. Seung, D. Rowley, P. Dubey, and H. Schreiber, Synergy betweenT-cell immunity and inhibition of paracrine stimulation causes tumor rejection, Proceedings of the National Academy of Sciences of the United States of America, issue.14, pp.926254-6258, 1995.

A. Serrano, . Menares-e-c, C. H. Garrido-t, J. H. Carolina, M. Ariadna et al., Interleukin 10 decreases MICA expression on melanoma cell surface, Immunology and Cell Biology, vol.14, issue.3, pp.447-57, 2011.
DOI : 10.1016/0003-2697(87)90021-2
URL : http://www.nature.com/icb/journal/v89/n3/pdf/icb2010100a.pdf

D. Siemens, J. Heaton, M. Adams, J. Kawakami, and C. Graham, Phase II Study of Nitric Oxide Donor for Men With Increasing Prostate-specific Antigen Level After Surgery or Radiotherapy for Prostate Cancer, Urology, vol.74, issue.4, 2009.
DOI : 10.1016/j.urology.2009.03.004

V. Simhadri, M. Dimitrova, M. J. Zenarruzabeitia, O. Zhong, W. Ozawa et al., A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells, PLOS ONE, vol.29, issue.4, 2015.
DOI : 10.1371/journal.pone.0124677.s001

N. Singh, Molecular Modelling of, Human Multidrug Resistance Protein, vol.5, issue.ABCC5, 2016.

F. J. Sharom, The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?, Journal of Membrane Biology, vol.160, issue.3, pp.161-75, 1997.
DOI : 10.1007/s002329900305

N. Shani and D. Valle, [56] Peroxisomal ABC transporters, Peroxisomal ABC transporters, pp.753-76, 1998.
DOI : 10.1016/S0076-6879(98)92058-4

S. Shahrzad, K. Lacombe, U. Adamcic, K. Minhas, and B. L. Coomber, Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia, Cancer Letters, vol.297, issue.1, pp.75-83, 2010.
DOI : 10.1016/j.canlet.2010.04.027

R. A. Shilling, New light on multidrug binding by an ATP-binding-cassette transporter, Trends in Pharmacological Sciences, vol.27, issue.4, pp.195-203, 2006.
DOI : 10.1016/j.tips.2006.02.008

N. Singh, Molecular Modelling of, Human Multidrug Resistance Protein, vol.5, issue.ABCC5, 2016.

J. D. Smith, V. M. Brunner, and S. Jigjidsuren, Lack of Effect of MICA Antibodies on Graft Survival Following Heart Transplantation, American Journal of Transplantation, vol.86, issue.8, pp.1912-1919, 2009.
DOI : 10.1097/00007890-199457110-00016

F. Snijdewint, V. Mensdorff-pouilly, S. Karuntu-wanamarta, A. Verstraeten, A. Livingston et al., Antibody-dependent cell-mediated cytotoxicity can be induced by MUC1 peptide vaccination of breast cancer patients, International Journal of Cancer, vol.58, issue.12, pp.97-106, 2001.
DOI : 10.1007/978-1-4757-9966-8_59

. Société-canadienne-du-cancer, Types de chimiothérapie, p.2015

. Disponible, ca/fr-ca/cancer-information/diagnosis-andtreatment/chemotherapy- and-other-drug-therapies/chemotherapy/types-of-chemotherapy, 2011.

G. M. Spaggiari, R. Carosio, D. Pende, S. Marcenaro, P. Rivera et al., NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46, European Journal of Immunology, vol.273, issue.6, pp.1656-1665, 2001.
DOI : 10.1074/jbc.273.13.7205

P. Stacpoole, T. Kurtz, Z. Han, and T. Langaee, Role of dichloroacetate in the treatment of genetic mitochondrial diseases Adv Drug Deliv Rev, pp.13-141478, 2008.

X. X. Stander, B. A. Stander, and A. M. Joubert, In vitro effects of an in silico-modelled 17?-estradiol derivative in combination, 2011.

J. Stefkova, R. Poledne, and J. A. Hubacek, ATP-binding cassette (ABC) transporters in human metabolism and diseases, Physiol Res, vol.53, issue.3, pp.235-278, 2004.

N. Stern-ginossar, E. Tili, J. Michaille, and C. Croce, Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D, Nature Immunology, vol.184, issue.9, pp.1065-1073, 2008.
DOI : 10.4049/jimmunol.171.12.6891

N. Stern-ginossar and O. Mandelboim, An integrated view of the regulation of NKG2D ligands, Immunology, vol.206, issue.Suppl, pp.1-6, 2009.
DOI : 10.1126/science.1155390

S. Strautnieks, L. Bull, A. Knisely, S. Kocoshis, N. Dahl et al., A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis, Nat Genet, vol.20, issue.3, pp.233-241, 1998.

B. Anduix, T. F. Gajewski, P. D. Greenberg, and P. Kalinski, Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting, J. Immunother. Cancer, vol.1, 2013.

J. Strid, S. J. Roberts, and R. B. Filler, Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis, Nature Immunology, vol.7, issue.2, pp.146-154, 2008.
DOI : 10.4049/jimmunol.179.8.5126

R. C. Sun, P. G. Board, and A. C. Blackburn, Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells, Molecular Cancer, vol.10, issue.1, p.142, 2011.
DOI : 10.1158/1078-0432.CCR-09-2590

G. Sutendra and E. D. Michelakis, Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology, Frontiers in Oncology, vol.3, 2013.
DOI : 10.3389/fonc.2013.00038

G. Sutendra, P. Dromparis, A. Kinnaird, T. H. Stenson, A. Haromy et al., Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer, Oncogene, vol.30, issue.13, pp.1638-1650, 2013.
DOI : 10.1038/onc.2011.113

G. Szakács, J. K. Joseph, A. Ludwig, C. B. , and M. M. , Targeting multidrug resistance in cancer, Nature Reviews Drug Discovery, vol.57, issue.Pt 11, pp.219-253, 2006.
DOI : 10.1016/S0304-3835(99)00182-2

M. Terabe and J. Berzofsky, NKT cells in immunoregulation of tumor immunity: a new immunoregulatory axis, Trends in Immunology, vol.28, issue.11, pp.491-496, 2007.
DOI : 10.1016/j.it.2007.05.008

V. Tieng, Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA, Proceedings of the National Academy of Sciences, vol.167, issue.10, pp.2977-2982, 2002.
DOI : 10.4049/jimmunol.167.10.5527

S. Textor, N. Fiegler, A. Arnold, A. Porgador, T. Hofmann et al., Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2, Cancer Research, vol.71, issue.18, pp.5998-600910, 2011.
DOI : 10.1158/0008-5472.CAN-10-3211

C. Une, J. Andersson, and A. Orn, Role of IFN-alpha/beta and IL-12 in the activation of natural killer cells and interferon-gamma production during experimental infection with Trypanosoma cruzi, Clinical and Experimental Immunology, vol.71, issue.2, pp.195-201, 2003.
DOI : 10.1128/IAI.70.1.36-48.2002

A. Unni, T. Bondar, and R. Medzhitov, Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance, Proceedings of the National Academy of Sciences, vol.15, issue.16, pp.1686-1691, 2008.
DOI : 10.1101/gad.906601

M. Valés-gómez, The Impact of Glycosyl-Phosphatidyl-Inositol Anchored MICA Alleles on Novel NKG2D-Based Therapies, Frontiers in Immunology, vol.6, p.193, 2015.
DOI : 10.3389/fimmu.2015.00193

M. G. Vander-heiden, L. C. Cantley, and C. B. Thompson, Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation, Science, vol.26, issue.1, pp.1029-1033, 2009.
DOI : 10.1038/nrc2536

M. Van-kuijck, G. F. Kool, A. Merkx, R. J. Geurts-van-kessel, P. M. Bindels et al., « Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization, Cytogenetics and cell genetics, vol.77, pp.3-4, 1997.

S. Vella, M. Conti, R. Tasso, R. Cancedda, and A. Pagano, Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells, International Journal of Cancer, vol.25, issue.Suppl 1, pp.1484-1493, 2012.
DOI : 10.1159/000315098
URL : http://onlinelibrary.wiley.com/doi/10.1002/ijc.26173/pdf

M. Verneris, M. Karimi, J. Baker, A. Jayaswal, and R. Negrin, Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells, Blood, vol.103, issue.8, pp.3065-3072, 2004.
DOI : 10.1182/blood-2003-06-2125

M. Villalba, N. Coudronniere, M. Deckert, E. Teixeiro, P. Mas et al., A Novel Functional Interaction between Vav and PKC?? Is Required for TCR-Induced T Cell Activation, Immunity, vol.12, issue.2, pp.151-160, 2000.
DOI : 10.1016/S1074-7613(00)80168-5

M. Villalba, M. G. Rathore, N. Lopez-royuela, E. Krzywinska, J. Garaude et al., From tumor cell metabolism to tumor immune escape, The International Journal of Biochemistry & Cell Biology, vol.45, issue.1, pp.106-113, 2013.
DOI : 10.1016/j.biocel.2012.04.024
URL : https://hal.archives-ouvertes.fr/inserm-00726717

E. Vivier, E. Tomasello, M. Baratin, T. Walzer, and S. Ugolini, Functions of natural killer cells, Nature Immunology, vol.178, issue.5, pp.503-510, 2008.
DOI : 10.1073/pnas.050588297
URL : https://hal.archives-ouvertes.fr/hal-00294184

E. Vivier, D. H. Raulet, A. Moretta, M. A. Caligiuri, L. Zitvogel et al., Innate or Adaptive Immunity? The Example of Natural Killer Cells, Science, vol.5, issue.5, pp.44-49, 2011.
DOI : 10.1038/nri1603
URL : https://hal.archives-ouvertes.fr/hal-00611585

E. Vivier, S. Ugolini, D. Blaise, C. Chabannon, and L. Brossay, Targeting natural killer cells and natural killer T cells in cancer, Nature Reviews Immunology, vol.5, issue.4, pp.239-252, 2012.
DOI : 10.1038/nri1603
URL : https://hal.archives-ouvertes.fr/hal-00685473

K. H. Vousden and C. Prives, Blinded by the Light: The Growing Complexity of p53, Cell, vol.137, issue.3, pp.413-431, 2009.
DOI : 10.1016/j.cell.2009.04.037

O. Volpert, T. Fong, A. Koch, J. Peterson, C. Waltenbaugh et al., Inhibition of Angiogenesis by Interleukin 4, The Journal of Experimental Medicine, vol.151, issue.6, pp.1039-1046, 1998.
DOI : 10.1073/pnas.87.17.6624

T. Voron, E. Marcheteau, S. Pernot, O. Colussi, T. Eric et al., Control of the immune response by pro-angiogenic factors EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival, Front Oncol Oncogene, issue.453, pp.70-72, 2006.

T. Voron, E. Marcheteau, S. Pernot, O. Colussi, J. T. Magali et al., Control of the Immune Response by Pro-Angiogenic Factors, Frontiers in Oncology, vol.2, issue.1, p.70, 2014.
DOI : 10.1186/2051-1426-2-2

T. Waldmann, Immunotherapy: past, present and future, Nature Medicine, vol.9, issue.3, pp.269-77, 2003.
DOI : 10.1038/nm0303-269

T. A. Waldmann and Y. Tagaya, THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS, Annual Review of Immunology, vol.17, issue.1, pp.19-49, 1999.
DOI : 10.1146/annurev.immunol.17.1.19

E. J. Walker and J. W. Dow, Location and properties of two isoenzymes of cardiac adenylate kinase, Biochemical Journal, vol.203, issue.2, pp.361-370, 1982.
DOI : 10.1042/bj2030361

M. E. Wallace and M. J. Smyth, The role of natural killer cells in tumor control???effectors and regulators of adaptive immunity, Springer Seminars in Immunopathology, vol.27, issue.1, pp.49-64, 2005.
DOI : 10.1007/s00281-004-0195-x

L. M. Wang, A. Kimura, M. Satoh, and S. Mineshita, HLA Linked with Leprosy in Southern China: HLA-Linked Resistance Alleles to Leprosy, International Journal of Leprosy and Other Mycobacterial Diseases: Official Organ of the International Leprosy Association, vol.67, issue.4, pp.403-408, 1999.

O. Warburg, Warburg report on the metabolism of tumors, J. Chem. Educ, vol.7, p.179, 1930.

O. Warburg, On the Origin of Cancer Cells, Science, vol.123, issue.3191, pp.309-314, 1956.
DOI : 10.1126/science.123.3191.309

W. Mo and J. Zhang, Human ABCG2: structure, function, and its role in multidrug resistance, Int J Biochem Mol Biol, vol.3, issue.1, pp.1-27, 2011.

S. Wilson, T. Zhu, R. Khanna, and M. Pritz, Qantitative RT-PCR analyses of five evolutionary conserved genes in alligator brains during developement, Transl Neurosci, vol.2, issue.4, pp.339-343, 2011.

M. Wink, M. Ashour, and M. El-readi, Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents, Frontiers in Microbiology, vol.3, 2012.
DOI : 10.3389/fmicb.2012.00130

S. Woo, L. Corrales, and T. Gajewski, Innate Immune Recognition of Cancer, Annual Review of Immunology, vol.33, issue.1, pp.445-474, 2015.
DOI : 10.1146/annurev-immunol-032414-112043

I. Wortzel and R. Seger, The ERK Cascade: Distinct Functions within Various Subcellular Organelles, Genes & Cancer, vol.2, issue.3, pp.195-209, 2011.
DOI : 10.1177/1947601911407328

K. Yamamoto, Y. Fujiyama, A. Andoh, T. Bamba, and H. Okabe, Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2), Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1526, issue.1, pp.10-210, 2001.
DOI : 10.1016/S0304-4165(01)00099-X

Y. Yang, P. Shang, C. Cheng, D. Wang, P. Yang et al., Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: Design, synthesis and biological evaluation, European Journal of Medicinal Chemistry, vol.45, issue.9, pp.4300-4306, 2010.
DOI : 10.1016/j.ejmech.2010.06.032

J. Ye, I. Kaattari, C. Ma, and S. Kaattari, The teleost humoral immune response, Fish & Shellfish Immunology, vol.35, issue.6, pp.1719-1747, 2013.
DOI : 10.1016/j.fsi.2013.10.015

Y. Yoshida, H. Izumi, and T. Torigoe, P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA, Cancer Res, vol.63, pp.3729-3734, 2003.

J. Yu, A. G. Freud, and M. A. Caligiuri, Location and cellular stages of natural killer cell development, Trends in Immunology, vol.34, issue.12, pp.573-582, 2013.
DOI : 10.1016/j.it.2013.07.005

M. Young, M. Newby, and H. Wepsic, Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors, Cancer research, vol.47, issue.1, pp.100-105, 1987.

F. Zhang, W. Zhang, L. Liu, C. Fisher, D. Hui et al., Characterization of ABCB9, an ATP Binding Cassette Protein Associated with Lysosomes, Journal of Biological Chemistry, vol.267, issue.30, pp.275-23287, 2000.
DOI : 10.1095/biolreprod34.1.207

N. Zhang and A. F. Palmer, Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic, Biotechnology and Bioengineering, vol.109, issue.3, pp.1413-1420, 2011.
DOI : 10.1016/j.ygyno.2008.01.038

S. Zhang, X. Yang, and M. Morris, Flavonoids Are Inhibitors of Breast Cancer Resistance Protein (ABCG2)-Mediated Transport, Molecular Pharmacology, vol.65, issue.5, pp.1208-1216, 2004.
DOI : 10.1124/mol.65.5.1208

C. Zhang, Z. Jian, and S. Rui, Opposing effect of IFN?? and IFN?? on expression of NKG2 receptors: Negative regulation of IFN?? on NK cells, International Immunopharmacology, vol.5, issue.6, pp.1057-1067, 2005.
DOI : 10.1016/j.intimp.2005.02.003

Q. Zhang, J. Michael, C. , and D. W. Gjertsonl, HLA and MICA: Targets of Antibody-Mediated Rejection in Heart Transplantation, Transplantation, vol.91, issue.10, pp.1153-1158, 2011.
DOI : 10.1097/TP.0b013e3182157d60

J. Zhao, Y. Jiang, and L. Yuan, Functional MICA-129 polymorphism and serum levels of soluble MICA are correlated with ulcerative colitis in Chinese patients, Journal of Gastroenterology and Hepatology, vol.100, issue.3, pp.593-598, 2011.
DOI : 10.1073/pnas.1632807100

M. Zheng, S. Shen, and W. Huang, DCA increases the antitumor effects of capecitabine in a mouse B16 melanoma allograft and a human non-small cell lung cancer A549 xenograft, Cancer Chemotherapy and Pharmacology, vol.1, issue.2, pp.1031-1041, 2013.
DOI : 10.2174/157489206777442241

G. Zhou, J. Wang, M. Zhao, T. Xie, N. Tanaka et al., Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation, Molecular Cell, vol.54, issue.6, pp.960-974, 2014.
DOI : 10.1016/j.molcel.2014.04.024