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Etude de la dosimétrie par scintillateur plastique pour l'irradiation préclinique du petit animal à moyenne énergie

Abstract : Small animal micro-irradiators designed for preclinical radiotherapy experiments mimic human clinical irradiation techniques thus facilitating the transposition of radiobiological research findings to clinical practice. These devices deliver millimetric x-ray beams of medium-energy (< 300 keV) which implies specific dosimetric issues. The objective of this thesis was the implementation of plastic scintillating fiber dosimetry in this specific field of use, for which few existing dosimeters are suitable. In a first part, beams from a micro-irradiator were characterized. Dosimetric measurements along with energy spectra Monte Carlo simulations allowed the study of the dosimeter prototype performances. In the second part of this work, excellent dosimetric properties of the detector such as repeatability, reproducibility and dose response linearity were shown. Then, a major issue was to determine the detector energy dependence, which is inherent to medium-energy dosimetry and also an intrinsic property of plastic scintillator, below 100 keV. A calibration method based on the simulated energy spectra was proposed to correct this dependence in preclinical conditions (mini-beams, small scattering volume). The dosimeter showed very conclusive results for treatment plan verification in a heterogene phantom and during rats in vivo experiments. The dosimeter also demonstrated promising performances for online control of the delivered dose to mobile tumors, subject to the animal respiratory movements.
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Submitted on : Monday, January 22, 2018 - 4:38:23 PM
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  • HAL Id : tel-01690118, version 1



Coralie Le Deroff. Etude de la dosimétrie par scintillateur plastique pour l'irradiation préclinique du petit animal à moyenne énergie. Physique [physics]. Normandie Université, 2017. Français. ⟨NNT : 2017NORMC254⟩. ⟨tel-01690118⟩



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