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, Grâce à de nombreux transports transépithéliaux, il réabsorbe la totalité du glucose, des acides aminés et des protéines de bas poids moléculaires, ainsi que 80 % des ions HPO4 2- ou HCO3 -, 60 % des ions Na + , Cl -, K + , Ca 2+ , 75 % de l'eau et 30 % des ions Mg 2+ ultrafiltrés. Durant ma thèse, j'ai étudié les rôles physiologiques et physiopathologiques de deux protéines de transport exprimées dans le tubule proximal, au cours de deux études distinctes. Dans le cadre de ma première étude, j'ai évalué in vivo la fonction rénale de souris n'exprimant pas une protéine appelée Kir4, dont le rôle est inconnu. Nos résultats montrent que Kir4.2, associée à Kir5.1, forme un canal potassique basolatéral Kir4.2/Kir5.1 dans le tubule proximal. L'absence de Kir4.2 provoque chez la souris une acidose tubulaire proximale isolée, consécutive à une ammoniogénèse altérée. De fait, la perte de fonctionnalité de Kir4