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Etude de la dynamique biomoléculaire sous haute pression par diffusion neutronique

Abstract : Seeking new research options have always been the heart of scientific progress. Through this work, new elements are brought to start a discussion about molecular dynamics and biomolecule structure studied through high pressure experiments with neutron scattering. The project explores different subjects all gathered around the high pressure guideline. High pressure interest in biology might seem quite opaque: however, a large amount of points justifies this investigation field. A large part of the biosphere undergoes high pressure stress due to the fact of its presence in the deep sea, raising question about biological adaptation to high pressure environment, for example. High pressure in the last decades has raised interest on other purposes like food conservation or vaccine fabrication. These research fields are on the final stage of the steps studied in this work, that starts its origin through more theoretical and phenomenological events. The manuscript covers different areas such as dynamical transition or metastable state and denaturation of proteins through experiments designed to the need of the research. Such a field requires a gigantic amount of investigation while restraining the possibilities of generalization. Thus, the work is focused on neutron scattering as a probe for high pressure studies in biophysics in order to elaborate new research clues in the field dealt with.
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Jérémie Marion. Etude de la dynamique biomoléculaire sous haute pression par diffusion neutronique. Biophysique [physics.bio-ph]. Université Grenoble Alpes, 2015. Français. ⟨NNT : 2015GREAY091⟩. ⟨tel-01686695⟩

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