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Rôle de l'interleukine-33 dans des modèles expérimentaux d'inflammation chronique

Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease that is associated with severalmediators. The physiopathological mechanisms of this disease involve cellular and cytokinenetworks whose study helps to define potential therapeutic targets. IL-33 is a cytokine involved inmany inflammatory diseases although its role in chronic inflammation such as RA remainsunclear. The aim of this work is to study the role of IL-33 and its mode of action in twoexperimental models of chronic inflammation, collagen induced arthritis (CIA) and imiquimod(IMQ) induced psoriasis. First, we showed for that the administration of recombinant IL-33 duringthe early and late phases of CIA inhibits the clinical signs of the disease in mice C57BL/6. Thisprotective effect is associated with the response type 2 including expansion of ILC2, eosinophilsand Th2 cells. Furthermore, we demonstrated that access of IL-33 in our model induced TregST2L and promotes the acquisition of regulatory phenotypes of Tregs. These Tregs achieve animportant suppressive activity leading inhibition of CIA. Secondly, despite the expression of IL-33 in the joint and skin of mice with CIA and IMQ induced psoriasis, endogenous IL-33 is notnecessary for the development of these two chronic inflammation models. In addition, the absenceof this cytokine does not alter the T cell response in the CIA or psoriasis. [...]
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Submitted on : Wednesday, January 17, 2018 - 3:42:07 PM
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  • HAL Id : tel-01686637, version 1



Sara Khaleghparast Athari. Rôle de l'interleukine-33 dans des modèles expérimentaux d'inflammation chronique. Biologie cellulaire. Université Sorbonne Paris Cité, 2015. Français. ⟨NNT : 2015USPCD063⟩. ⟨tel-01686637⟩



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