Biochemical and molecular characterization of an original master sex determining gene in salmonids

Abstract : Sexual development is a fundamental and versatile process that shapes animal morphology, physiology and behavior. The underlying developmental process is composed of the sex determination and the sex differentiation. The initial triggers are often genetics called sex determining genes. To date, among the known sex determining genes, three gene families namely sox, dmrt and TGF-ß factors govern this developmental program. As exception to this rule, sdY “sexually dimorphic on the Y” does not belong to one of these families as it comes from the duplication / evolution of an ancestor gene related to immunity, i.e., the interferon related factor 9, irf9.sdY is the master sex determining gene in salmonids, a group of fishes that include species such as rainbow trout and Atlantic salmon. The present study was aimed to firstly characterize the features of SdY protein. Results indicate that SdY is predominantly localized in the cytoplasm, composed of a ß-sandwich core surrounded by three a-helices as well specific characteristics conferring a putative protein-protein interaction site. Secondly, the study was aimed to understand how SdY could trigger testicular differentiation. Altogether results propose that SdY would trigger testicular differentiation in salmonids by interacting with a prominent female factor.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-01686524
Contributor : Abes Star <>
Submitted on : Wednesday, January 17, 2018 - 2:55:07 PM
Last modification on : Thursday, February 28, 2019 - 1:32:30 AM
Long-term archiving on : Monday, May 7, 2018 - 8:56:10 PM

File

pdf2star-1516179696-pdfa_G7UO3...
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01686524, version 1

Collections

Citation

Sylvain Bertho. Biochemical and molecular characterization of an original master sex determining gene in salmonids. Animal biology. Agrocampus Ouest, 2016. English. ⟨NNT : 2016NSARB279⟩. ⟨tel-01686524⟩

Share

Metrics

Record views

198

Files downloads

46