Modeling and simulation of the motion of deformable interfaces in a confined geometry : application to the study of the flow of red blood cells in microcirculation

Abstract : Vesicles are extensively used as a model for understanding dynamicsand deformation of red blood cells at the individual level but also regarding collective phenomena and rheology. Vesicles' membranes withstand to bending butdo not have a shear resistance, unlike red blood cells, but they still share several dynamical properties with red blood cells, like tank-treading and tumbling under linear shear flow, or parachute and slipper shapes under Poiseuille flow. The red blood cells are known to form train of cells in the microcirculation attributed to attractive hydrodynamic interactions. We investigate numerically several kind of problems such as: (i) the dynamics of isolated cells; (ii) the hydrodynamic coupling between the red blood cells (by using vesicles as a model) subject to a Poiseuille flow under different confinements; (iii) the aggregation of red blood cells and formation of rouleaux; and (iv) the contribution of macromolecules in the formation of clusters under flow condition. The obtained results give a new insight into thephysics of deformable objects under confinement that are transposable to the flow of red blood cells in the microcirculation.
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Othmane Aouane. Modeling and simulation of the motion of deformable interfaces in a confined geometry : application to the study of the flow of red blood cells in microcirculation. Biological Physics [physics.bio-ph]. Université Grenoble Alpes, 2015. English. ⟨NNT : 2015GREAY096⟩. ⟨tel-01686225⟩

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