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Bases moléculaires et cellulaires des effets antidépresseurs de l'électro-convulsivothérapie (ECT)

Abstract : In Major depressive disorder, the electroconvulsive therapy (ECT) is recognized as an effective treatment to face drug-resistance and action latency of pharmacological agents. Although the therapeutic efficacy of ECT is internationally recognized, the ill-characterized biological effects of ECT contribute to discredit this treatment. Direct access of specific markers in human is not easy, prompting the development of the animal counterpart of ECT, the electro convulsive stimulations (ECS). To date, current results arising from ECS studies in animals remain not fully conclusive because mainly data have been obtained with unchallenged/naive animals. The objective of this project was to analyze the biological and behavioral effects of ECS treatment, on an animal model of psychiatric disorder: the MAP6-KO mice. Indeed MAP6-KO mice (also known as STOP KO mice) constitutively exhibit behavioural and biological features relevant to some aspects of major depressive disorder. We found that ECS treatment has an overall beneficial effect on several constitutive behavioural defects, displayed by MAP6 KO mice, with variable lasting times. At biological levels, ECS treatment did not induce detectable modification of brain proteins expression pattern, but induce an overall increase of hippocampal neurogenesis, and more particularly potentiate the survival rate of newborn neurons, probably through an increase dendritic complexity and dendritic spines density. We also found that ECS enhance dendritic spines density in vivo in cortical neurons and increase hippocampal levels of the trophic factor, BDNF. In summary our work provide evidence that ECS treatment when applied to MAP6 KO mice induces major neuronal plasticity events, the stronger being the increased integration rate of hippocampal new-born neurons.
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https://tel.archives-ouvertes.fr/tel-01685524
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Submitted on : Tuesday, January 16, 2018 - 2:47:07 PM
Last modification on : Monday, May 18, 2020 - 9:53:19 PM
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  • HAL Id : tel-01685524, version 1

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Julie Jonckheere Ruiz de Larrinaga. Bases moléculaires et cellulaires des effets antidépresseurs de l'électro-convulsivothérapie (ECT). Sciences agricoles. Université Grenoble Alpes, 2017. Français. ⟨NNT : 2017GREAV023⟩. ⟨tel-01685524⟩

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