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Theses

Synthèses de cryptophanes hydrosolubles adaptés à l’encapsulation du xénon, et d’hémicryptophanes fonctionnalisés pour la complexation de lanthanides (III), en vue d’applications en imagerie médicale

Abstract : This book details all the research work that has been done during three years of Ph-D. After a chapter dedicated to the general principles of supramolecular chemistry, and some of its applications, we focalise on the use of cage-shapes molecules (cryptophanes and hemicrypto-phanes) in order to build probes for biological imaging. We successively mention the way toward the synthesis of a hemicryptophane able to complex Gadolinium(III), to use it it as a proton-MRI contrast agent, then toward the elaboration of hydrosoluble cryptophanes adapted to 129Xe NMR and MRI. This PhD manuscript ends with the synthesis of a new hemicryptophane functionnalized to form complexes with Terbium(III) and Europium(III), whose fluorescence properties are promising.
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https://tel.archives-ouvertes.fr/tel-01685014
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Submitted on : Tuesday, January 16, 2018 - 1:01:29 AM
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  • HAL Id : tel-01685014, version 1

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Estelle Godart. Synthèses de cryptophanes hydrosolubles adaptés à l’encapsulation du xénon, et d’hémicryptophanes fonctionnalisés pour la complexation de lanthanides (III), en vue d’applications en imagerie médicale. Autre. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSEN041⟩. ⟨tel-01685014⟩

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