. Hz, 05 (s, 2 H), 5.10 (d, J = 8.1 Hz, 1 H), 6.56 (s, 1 H), 63 (d, J = 1.9 Hz, 1H ), 6.78 (d, J = 8.3 Hz, 1 H), p.9702

0. At, to a solution of N(Cbz)-Tyr(OAllyl)-OMe (120 mg, 0.32 mmol) and

. Hz, 60 (s, 3 H), 3.73 (br, 3 H), 3.78 (s, 3 H), 4, pp.3-17

J. =. -nmrt, ? (ppm): 1.57 (s, 3 H), 1.64 (s, 3 H), 3.75 (s, 3 H), MHz, vol.6, p.61

. Hz, 1 Hz, 1 H), p.75, 2016.

. Hz, 39 (td, J = 5.3, 14.2 Hz, 1 H), 3.76 (s, 3 H)

. Hz, 74 (s, 3 H), 3.77 (s, 3 H), 3.99 (s, 3 H), 6.12 (s, 1 H), 6.55 (d, J = 8.2 Hz, 1 H)

. Hz, 69 (s, 3 H), 6.63 ? 6

. Hz, 73 (s, 3 H), 3.81 (s, 3 H), 3.90 (d, J = 13.2 Hz, 1 H), 6.25 (s, 1 H), pp.75-76

. Hz, 69 (s, 1 H), 3.54 (dd, J = 6.2 Hz, 2 H), 3.58 (s, 3 H), Hz, 2 H), pp.27-32

0. At, Et3N (0.08 mL, 1.30 mmol), and tosyl chloride (273 mg, 1.40 mmol) were added. The reaction was stirred for 1h and quenched with HCl 1M (2 mL). The aqueous layer was extracted with EtOAc and the combined organic layers were washed with NaOH 1M solution, brine, dried and concentrated under vacuum to give a brown solid, DCM (2 mL), 1920.

J. Hzd, Hz, 1 H), 3.31 (d, J = 12.2 Hz, 1 H), 3.50 ? 3.54 (m, 1 H), 3.59 (t, J = 2.5 Hz, 1 H), 3.68 (s, 3 H), 3.71 (s, 3 H), 3.75 (s, 3 H), 3.78 (s, 3 H), 6.43 (d, p.36

. Hz, 17 (t, J = 7.3 Hz, 1 H), p.17

. Hz, Hz, 1 H), 3.76 (s, 3 H), 3.81 ? 3, p.615

0. At, SOCl2 (902 mg, 7.58 mmol, 0.56 mL) was added dropwise. The resulting mixture was stirred at reflux overnight, then cooled down to r.t and quenched by addition of NaHCO3 sat. solution. Aqueous layer was extracted with EtOAc, and combined organic layers were washed with water, brine, dried and concentrated under reduced pressure to afford the desired product (803 mg, 4.78 mmol) as a white powder in 94 % yield, MeOH (30 mL) Data for 341: IR (NaCl), ?, pp.3-778, 1147.