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Formulation, développement et validation de systèmes particulaires d'insuline en vue de leur administration par voie orale

Abstract : Insulinotherapy helps diabetics to regulate their glycaemia. This thesis is part of the ORAIL Bis project which aims to develop an oral insulin delivery system based on the double encapsulation of insulin. The developed vector is composed of a capsule containing insulin loaded particles (NPs) formulated with chitosan (CS) by complex coacervation or poly (lactic-co-glycolic) acid (PLGA) by double emulsion solvent evaporation. The objectives of the thesis are to stabilize chitosan NPs by crosslinking and freeze-drying, increase the bioavailability of NPs PLGA by mucoadhesion and transpose them to the industrial scale. Results showed that the combination of both strategies reduces the size of CS NPs, maintain a positive charge, give them stability and bioefficacy. Mucoadhesion failed to increase the bioavailability of PLGA NPs. A negative charge allows to improve their biological efficacy and are transposed to industrial scale. The encapsulation of these NPs in an alginate capsule allowed to validate in vivo the concept of double encapsulation of insulin.
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Submitted on : Thursday, January 11, 2018 - 5:28:30 PM
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  • HAL Id : tel-01681651, version 2

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Mouhamadou Diop. Formulation, développement et validation de systèmes particulaires d'insuline en vue de leur administration par voie orale. Pharmacie galénique. Université de Strasbourg, 2015. Français. ⟨NNT : 2015STRAJ081⟩. ⟨tel-01681651v2⟩

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