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Formation des sites d'exocytose dans les cellules chromaffines : importance fonctionnelle, régulation et externalisation de l'Annexine A2

Abstract : Exocytosis is a fundamental biological mechanism which allows liberation of the contents of secretory granules into the extracellular medium. This calcium-regulated process requires the formation of lipid domains for the structural and spatial organisation of exocytotic sites. In the chromaffin cell, annexine A2, a calcium-, actin- and lipid-binding protein participates in the formation and stabilization of lipid microdomains. The major advance resulting from my thesis is the elucidation of the three-dimensional organization and the role of actin at the exocytotic site. Phosphorylation of the tyrosine 23 is known to affect the binding of annexin A2 to actin filaments and plasma membrane, two major actors of the exocytotic process and my results highlight the functional importance of this phosphorylation on exocytosis. Furthermore, tyrosine 23 phosphorylation also triggers a translocation of annexin A2 to the external face of the plasma membrane. The role and functional signification of this externalization was also examined.
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Submitted on : Thursday, January 11, 2018 - 5:14:29 PM
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Marion Gabel. Formation des sites d'exocytose dans les cellules chromaffines : importance fonctionnelle, régulation et externalisation de l'Annexine A2. Neurosciences [q-bio.NC]. Université de Strasbourg, 2016. Français. ⟨NNT : 2016STRAJ038⟩. ⟨tel-01681637⟩

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