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Molecular mechanisms underlying heterochromatin formation in the mouse embryo

Abstract : To study the formation of heterochromatin in mouse preimplantation embryo, I focused on two different genetic regions – pericentric repeats and L1 transposable elements - in order to investigate the mechanisms that lead to their repression and the distinct role that these regions can play during the process of development and cell division. My experiments show that the specific spatial organization of pericentric domains is essential for their repression and for their correct organization. Moreover, my findings suggest that defects in organization of heterochromatin lead to improper cell division and proliferation. The second part of my thesis shows that the tight regulation of L1 transposable elements is required for the preimplantation development of mouse embryos. Additionally, it is the first attempt to elucidate the biology of L1 elements in the early mouse embryo through the use of targeted transcription modifiers.
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Submitted on : Thursday, January 11, 2018 - 5:26:30 PM
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  • HAL Id : tel-01681610, version 2

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Joanna Weronika Jachowicz. Molecular mechanisms underlying heterochromatin formation in the mouse embryo. Embryology and Organogenesis. Université de Strasbourg, 2015. English. ⟨NNT : 2015STRAJ094⟩. ⟨tel-01681610v2⟩

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