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Etude expérimentale des dynamiques temporelles du comportement normal et pathologique chez le rat et la souris

Abstract : Modern neuroscience highlights the need for designing sophisticated behavioral readout of internal cognitive states. From a thorough analysis of classical behavioural tests, my results support the hypothesis that sensory hypersensitivity might be the cause of other behavioural deficits, and confirm the potassium channel BKCa as a potentially relevant molecular target for the development of drug edication against Fragile X Syndrome / Autism Spectrum Disorders. I have also used an innovative device, based on pressure sensors that can non-invasively detect the slightest animal movement with unprecedented sensitivity and time resolution, during spontaneous behaviour. Analysing this signal with sophisticated computational tools, I could demonstrate the outstanding potential of this methodology for behavioural phenotyping in general, and more specifically for the investigation of pain, fear or locomotion in normal mice and models of neurodevelopmental and neurodegenerative disorders.
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https://tel.archives-ouvertes.fr/tel-01681305
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Submitted on : Thursday, January 11, 2018 - 3:13:44 PM
Last modification on : Friday, May 25, 2018 - 1:40:53 PM
Long-term archiving on: : Saturday, May 5, 2018 - 2:41:33 AM

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  • HAL Id : tel-01681305, version 1

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Citation

Maria Isabel Carreno-Muñoz. Etude expérimentale des dynamiques temporelles du comportement normal et pathologique chez le rat et la souris. Médecine humaine et pathologie. Université de Bordeaux, 2017. Français. ⟨NNT : 2017BORD0676⟩. ⟨tel-01681305⟩

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