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Modulation of cerebellar Purkinje cell discharge by subthreshold granule cell inputs

Abstract : Rate and temporal coding in Purkinje cells (PC), the sole output of the cerebellar cortex, play a major role in motor control. PC receives excitatory inputs from granule cells (GC) which also provide feedforward inhibition on PC through the activation of molecular layer interneurons (MLI). In this thesis, I studied the influence of the combined action of excitation/inhibition (E/I) balance and short-term plasticity of GC-MLI-PC synapses on PC discharge, by using electrophysiological recordings, optogenetic stimulation and modelling. This work demonstrates that E/I balances are not equalized in the cerebellar cortex and showed a wide distribution of PC discharge modulation in response to GC inputs, from an increase to a shut down of the discharge. The number of stims in GC bursts strongly controls the strength and sign of PC modulation. Lastly, the interplay between short-term plasticity and E/I balance implements complex but reproducible output patterns of PC responses to GC inputs that should play a key role in stimulus encoding by the cerebellar cortex.
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Submitted on : Tuesday, January 2, 2018 - 1:33:40 AM
Last modification on : Wednesday, March 18, 2020 - 9:48:53 AM
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  • HAL Id : tel-01674188, version 1



Anais Grangeray-Vilmint. Modulation of cerebellar Purkinje cell discharge by subthreshold granule cell inputs. Neurobiology. Université de Strasbourg, 2016. English. ⟨NNT : 2016STRAJ023⟩. ⟨tel-01674188⟩



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