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Optical imaging and drug delivery using soft- and hard- nanomaterials

Abstract : The work described in this thesis focuses on the development of soft- and hard-materials as well as their interaction with biological cells for applications in the field of theranostics covering imaging, sensing, and gene, and cancer therapy. In this context, we first investigated the use of phosphorescent self-assembled platinum(II) complexes as cellular probes. We extended the concept stimulated emission-based bioimaging by generating a laser-like emission coming from a single biological cell without using any conventional optical cavity. In addition, we successfully developed multifunctional nanocarriers based on porous hard materials, namely zeolites-L and mesoporous silica nanoparticles for drug and oligonucleotide delivery in vitro and they were tested to treat glioblastoma. Another nanovector, which is constructed from biodegradable silica, was also synthesized and its ability to encapsulate proteins and release them in living cells upon degradation of the structure in reductive environment was demonstrated. Finally, the use of novel plasmonic structures based on breakable silica-coated silver nanoparticles for detection of reducing agents was successfully investigated.
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Submitted on : Tuesday, January 2, 2018 - 1:35:43 AM
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  • HAL Id : tel-01674163, version 2



Dedy Septiadi. Optical imaging and drug delivery using soft- and hard- nanomaterials. Other. Université de Strasbourg, 2015. English. ⟨NNT : 2015STRAF036⟩. ⟨tel-01674163v2⟩



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