Global organization of metabolic fluxes in the bacterium Escherichia coli, Nature, vol.427, issue.6977, pp.839-843, 2004. ,
DOI : 10.1038/nature02289
Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements, Metabolic Engineering, vol.8, issue.4, pp.324-337, 2006. ,
DOI : 10.1016/j.ymben.2006.01.004
Dynamic metabolic flux analysis???tools for probing transient states of metabolic networks, Current Opinion in Biotechnology, vol.24, issue.6, pp.973-978, 2013. ,
DOI : 10.1016/j.copbio.2013.03.018
Methods and advances in metabolic flux analysis: a mini-review, Journal of Industrial Microbiology & Biotechnology, vol.45, issue.4, pp.1-9, 2015. ,
DOI : 10.1002/bit.260450403
Quantitative lipid composition of cell envelopes of Corynebacterium glutamicum elucidated through reverse micelle extraction, Proceedings of the National Academy of Sciences, vol.101, issue.5, pp.15360-15365, 2011. ,
DOI : 10.1007/BF00167910
Thermodynamic-based computational profiling of cellular regulatory control in hepatocyte metabolism, American Journal of Physiology-Endocrinology and Metabolism, vol.288, issue.3, pp.633-644, 2005. ,
DOI : 10.1006/jsre.2000.5820
Identification and characterization of a transcriptional regulator, SucR, that influences sucCD transcription in Corynebacterium glutamicum, Biochemical and Biophysical Research Communications, vol.401, issue.2, pp.300-305, 2010. ,
DOI : 10.1016/j.bbrc.2010.09.057
Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis, Molecular Systems Biology, vol.176, issue.1, p.709, 2013. ,
DOI : 10.1038/ng1348
URL : https://hal.archives-ouvertes.fr/hal-01204283
Coordination of microbial metabolism, Nature Reviews Microbiology, vol.6, issue.5, pp.327-340, 2014. ,
DOI : 10.1038/msb.2010.10
Growth rate-dependent modulation of carbon flux through central metabolism and the kinetic consequences for glucose-limited chemostat cultures of Corynebacterium glutamicum, Applied and Environmental Microbiology, vol.62, issue.2, pp.429-436, 1996. ,
Batch kinetics of Corynebacterium glutamicum during growth on various carbon substrates: use of substrate mixtures to localise metabolic bottlenecks, Applied Microbiology and Biotechnology, vol.40, issue.4, pp.526-530, 1993. ,
DOI : 10.1007/BF00175743
Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production, PLoS Computational Biology, vol.452, issue.8, pp.1000489-2009, 2009. ,
DOI : 10.1371/journal.pcbi.1000489.s006
URL : https://doi.org/10.1371/journal.pcbi.1000489
Regulation of Gene Expression in Flux Balance Models of Metabolism, Journal of Theoretical Biology, vol.213, issue.1, pp.73-88, 2001. ,
DOI : 10.1006/jtbi.2001.2405
Constraints-based models: Regulation of Gene Expression Reduces the Steady-state Solution Space, Journal of Theoretical Biology, vol.221, issue.3, pp.309-325, 2003. ,
DOI : 10.1006/jtbi.2003.3071
Integrating metabolic, transcriptional regulatory and signal transduction models in Escherichia coli, Bioinformatics, vol.24, issue.18, pp.2044-2050, 2008. ,
DOI : 10.1093/bioinformatics/btn352
Carbon-Flux Distribution within Streptomyces coelicolor Metabolism: A Comparison between the Actinorhodin-Producing Strain M145 and Its Non-Producing Derivative M1146, PLoS ONE, vol.91, issue.12, p.84151, 2013. ,
DOI : 10.1371/journal.pone.0084151.s005
Control of Isocitrate Dehydrogenase Catalytic Activity by Protein Phosphorylation in <i>Escherichia coli</i>, Journal of Molecular Microbiology and Biotechnology, vol.259, issue.3-4, pp.3-4, 2005. ,
DOI : 10.1016/0378-1119(94)00660-K
Modeling and simulation of genetic regulatory systems : a literature review, Journal of Computational Biology, vol.9, issue.1, pp.67-103, 2002. ,
Qualitative simulation of genetic regulatory networks using piecewise-linear models, Bulletin of Mathematical Biology, vol.66, issue.2, pp.301-340, 2004. ,
DOI : 10.1016/j.bulm.2003.08.010
URL : https://hal.archives-ouvertes.fr/hal-00173849
Plant genome-scale metabolic reconstruction and modelling, Current Opinion in Biotechnology, vol.24, issue.2, pp.271-277 ,
How Molecular Competition Influences Fluxes in Gene Expression Networks, PLoS ONE, vol.74, issue.12, pp.28494-2011, 2011. ,
DOI : 10.1371/journal.pone.0028494.s013
Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme., Journal of Bacteriology, vol.177, issue.3, pp.774-782, 1995. ,
DOI : 10.1128/jb.177.3.774-782.1995
Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network, Proceedings of the National Academy of Sciences, vol.14, issue.3, pp.13134-13139, 2003. ,
DOI : 10.1002/(SICI)1097-0061(199802)14:3<203::AID-YEA205>3.0.CO;2-8
Alternative Pathways of Carbon Dioxide Fixation: Insights into the Early Evolution of Life?, Annual Review of Microbiology, vol.65, issue.1, pp.631-658, 2011. ,
DOI : 10.1146/annurev-micro-090110-102801
Modeling gene regulatory networks with piecewise linear differential equations, European Journal of Operational Research, vol.181, issue.3, pp.1148-1165, 2007. ,
DOI : 10.1016/j.ejor.2005.11.044
Purification and characterization of malate dehydrogenase from Corynebacterium glutamicum, Journal of Bioscience and Bioengineering, vol.95, issue.6, pp.562-566, 2003. ,
DOI : 10.1016/S1389-1723(03)80162-7
Acetate metabolism and its regulation in Corynebacterium glutamicum, Journal of Biotechnology, vol.104, issue.1-3, pp.99-122, 2003. ,
DOI : 10.1016/S0168-1656(03)00167-6
Functional States of the Genome-Scale Escherichia Coli Transcriptional Regulatory System, PLoS Computational Biology, vol.4, issue.6, pp.1000403-2009, 2009. ,
DOI : 10.1371/journal.pcbi.1000403.s012
Cloning of the Malic Enzyme Gene from Corynebacterium glutamicum and Role of the Enzyme in Lactate Metabolism, Applied and Environmental Microbiology, vol.66, issue.7, pp.2981-2988, 2000. ,
DOI : 10.1128/AEM.66.7.2981-2987.2000
Changes in enzyme activities at the pyruvate node in Références bibliographiques rium glutamicum, Applied and Environmental Microbiology, vol.60, issue.7, pp.2501-2507, 1994. ,
Regulation of phospho(enol)-pyruvate-and oxaloacetate-converting enzymes in Corynebacterium glutamicum, Applied Microbiology and Biotechnology, vol.41, issue.1, pp.47-52, 1994. ,
Purification and properties of oxaloacetate decarboxylase fromCorynebacterium glutamicum, Antonie van Leeuwenhoek, vol.41, issue.2, pp.221-227, 1995. ,
DOI : 10.1007/BF00871217
Modelling and analysis of gene regulatory networks, Nature Reviews Molecular Cell Biology, vol.18, issue.10, pp.770-780, 2008. ,
DOI : 10.1007/BF02459576
An ontology for biological function based on molecular interactions, Bioinformatics, vol.16, issue.3, pp.269-285, 2000. ,
DOI : 10.1093/bioinformatics/16.3.269
The Pathway Tools software, Bioinformatics, vol.18, issue.Suppl 1, pp.225-232, 2002. ,
DOI : 10.1093/bioinformatics/18.suppl_1.S225
Pathway Tools version 13.0: integrated software for pathway/genome informatics and systems biology, Briefings in Bioinformatics, vol.11, issue.1, pp.40-79, 2010. ,
DOI : 10.1093/bib/bbp043
A Whole-Cell Computational Model Predicts Phenotype from Genotype, Cell, vol.150, issue.2, pp.389-401, 2012. ,
DOI : 10.1016/j.cell.2012.05.044
Metabolic stability and epigenesis in randomly constructed genetic nets, Journal of Theoretical Biology, vol.22, issue.3, pp.437-467, 1969. ,
DOI : 10.1016/0022-5193(69)90015-0
Advances in flux balance analysis, Current Opinion in Biotechnology, vol.14, issue.5, pp.491-496, 2003. ,
DOI : 10.1016/j.copbio.2003.08.001
EcoCyc: fusing model organism databases with systems biology, Database issue, pp.605-612, 2013. ,
DOI : 10.1093/nar/gks1027
Recent advances in reconstruction and applications of genome-scale metabolic models, Current Opinion in Biotechnology, vol.23, issue.4, pp.617-623, 2012. ,
DOI : 10.1016/j.copbio.2011.10.007
L-Glutamate Production, Handbook of Corynebacterium glutamicum, pp.439-457, 2005. ,
DOI : 10.1201/9781420039696.pt6
STUDIES ON THE AMINO ACID FERMENTATION, The Journal of General and Applied Microbiology, vol.3, issue.3, pp.193-205, 1957. ,
DOI : 10.2323/jgam.3.193
metabolic network, Biotechnology and Bioengineering, vol.68, issue.2, pp.583-597, 2009. ,
DOI : 10.1099/00221287-147-5-1365
Genetic and Functional Analysis of the Soluble Oxaloacetate Decarboxylase from Corynebacterium glutamicum, Journal of Bacteriology, vol.192, issue.10, pp.2604-2612, 2010. ,
DOI : 10.1128/JB.01678-09
Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry, European Journal of Biochemistry, vol.252, issue.17, pp.3525-3542, 2003. ,
DOI : 10.1042/bj2580121
Molecular geometry in enzyme action, Journal of Cellular and Comparative Physiology, vol.3, issue.S1, pp.217-234, 1956. ,
DOI : 10.1039/CT9252701385
Purification and characterization of succinate:menaquinone oxidoreductase from Corynebacterium glutamicum, Archives of Microbiology, vol.299, issue.5, pp.317-324, 2005. ,
DOI : 10.1016/S0005-2728(01)00232-8
An advanced web query interface for biological databases, Database, vol.2010, issue.0, p.6, 2010. ,
DOI : 10.1093/database/baq006
Correction: Dynamic Analysis of Integrated Signaling, Metabolic, and Regulatory Networks, PLoS Computational Biology, vol.4, issue.6, p.1000086, 2008. ,
DOI : 10.1371/annotation/5594348b-de00-446a-bdd0-ec56e70b3553
Dynamic metabolic flux analysis (DMFA): A framework for determining fluxes at metabolic non-steady state, Metabolic Engineering, vol.13, issue.6, pp.745-755, 2011. ,
DOI : 10.1016/j.ymben.2011.09.010
Dynamic metabolic flux analysis demonstrated on cultures where the limiting substrate is changed from carbon to nitrogen and vice versa Cité en, Journal of Biomedicine and Biotechnology, vol.2010, p.137, 2010. ,
Constraining the metabolic genotype???phenotype relationship using a phylogeny of in silico methods, Nature Reviews Microbiology, vol.6, issue.4, pp.291-305, 2012. ,
DOI : 10.1371/journal.pone.0016274
ABSTRACT, Applied and Environmental Microbiology, vol.77, issue.11, pp.3571-3581, 2011. ,
DOI : 10.1128/AEM.02713-10
An interval approach for dealing with flux distributions and elementary modes activity patterns, Journal of Theoretical Biology, vol.246, issue.2, pp.290-308, 2007. ,
DOI : 10.1016/j.jtbi.2006.12.029
A procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain and/or insufficient, BMC Bioinformatics, vol.8, issue.1, p.421, 2007. ,
DOI : 10.1186/1471-2105-8-421
A possibilistic framework for constraint-based metabolic flux analysis, BMC Systems Biology, vol.3, issue.1, p.79, 2009. ,
DOI : 10.1186/1752-0509-3-79
Dynamic estimations of metabolic fluxes with constraint-based models and possibility theory, Journal of Process Control, vol.22, issue.10, pp.1946-1955, 2012. ,
DOI : 10.1016/j.jprocont.2012.09.001
Dynamic analysis of optimality in myocardial energy metabolism under normal and ischemic conditions, Molecular Systems Biology, vol.60, issue.1, 2006. ,
DOI : 10.1161/01.RES.67.6.1481
Modeling formalisms in Systems Biology, AMB Express, vol.1, issue.1, pp.45-57, 2011. ,
DOI : 10.1186/2191-0855-1-45
Dynamic Flux Balance Analysis of Diauxic Growth in Escherichia coli, Biophysical Journal, vol.83, issue.3, pp.1331-1340, 2002. ,
DOI : 10.1016/S0006-3495(02)73903-9
The effects of alternate optimal solutions in constraint-based genome-scale metabolic models, Metabolic Engineering, vol.5, issue.4, pp.264-276, 2003. ,
DOI : 10.1016/j.ymben.2003.09.002
In vivo kinetics with rapid perturbation experiments in Saccharomyces cerevisiae using a second-generation BioScope, Metabolic Engineering, vol.8, issue.4, pp.370-383, 2006. ,
DOI : 10.1016/j.ymben.2006.02.002
SIMULATION OF PROKARYOTIC GENETIC CIRCUITS, Annual Review of Biophysics and Biomolecular Structure, vol.27, issue.1, pp.199-224, 1998. ,
DOI : 10.1146/annurev.biophys.27.1.199
Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum, European Journal of Biochemistry, vol.254, issue.2, pp.395-403, 1998. ,
DOI : 10.1046/j.1432-1327.1998.2540395.x
Functions of the Membrane-Associated and Cytoplasmic Malate Dehydrogenases in the Citric Acid Cycle of Corynebacterium glutamicum, Journal of Bacteriology, vol.182, issue.24, pp.6884-6891, 2000. ,
DOI : 10.1128/JB.182.24.6884-6891.2000
Energetic consequences of multiple K+ uptake systems in Escherichia coli, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.851, issue.2, pp.223-228, 1986. ,
DOI : 10.1016/0005-2728(86)90129-5
Physiology of the bacterial cell : a molecular approach, 1990. ,
Roles of pyruvate kinase and malic enzyme in Corynebacterium glutamicum for growth on carbon sources requiring gluconeogenesis, Archives of Microbiology, vol.290, issue.5, pp.354-363, 2004. ,
DOI : 10.1099/00221287-148-3-685
Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis, Bioprocess and Biosystems Engineering, vol.15, issue.1???3, pp.533-545, 2011. ,
DOI : 10.1007/BF00762376
An integrated open framework for thermodynamics of reactions that combines accuracy and coverage, Bioinformatics, vol.28, issue.15, pp.2037-2044, 2012. ,
DOI : 10.1093/bioinformatics/bts317
What is flux balance analysis?, Nature Biotechnology, vol.19, issue.3, pp.245-248, 2010. ,
DOI : 10.1038/nrmicro1949
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108565/pdf
Osmolality, Temperature, and Membrane Lipid Composition Modulate the Activity of Betaine Transporter BetP in Corynebacterium glutamicum, Journal of Bacteriology, vol.189, issue.20, pp.7485-7496, 2007. ,
DOI : 10.1128/JB.00986-07
Systems biology : properties of reconstructed networks, 2006. ,
DOI : 10.1017/CBO9780511790515
Corynebacterium glutamicum : a dissection of the PTS, Journal of Molecular Microbiology and Biotechnology, vol.3, issue.3, pp.423-428, 2001. ,
Innovation: Metabolomics: the apogee of the omics trilogy, Nature Reviews Molecular Cell Biology, vol.17, issue.4, pp.263-269, 2012. ,
DOI : 10.1016/j.chembiol.2010.03.009
Pyruvate carboxylase as an anaplerotic enzyme in Corynebacterium glutamicum, Microbiology, vol.143, issue.4, pp.1095-1103, 1997. ,
DOI : 10.1099/00221287-143-4-1095
Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene, Microbiology, vol.144, issue.4, pp.915-927, 1998. ,
DOI : 10.1099/00221287-144-4-915
Pyruvate Références bibliographiques carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum Cité en, Journal of Molecular Microbiology and Biotechnology, vol.3, issue.2, pp.295-300, 2001. ,
In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum, The Journal of Biological Chemistry, vol.275, issue.46, pp.35932-35941, 2000. ,
Metabolic Consequences of Altered PhosphoenolpyruvateCarboxykinase Activity in Corynebacterium glutamicum Reveal Anaplerotic Regulation Mechanisms in Vivo, Metabolic Engineering, vol.3, issue.4, pp.344-361, 2001. ,
DOI : 10.1006/mben.2001.0198
Kommunikation mit Automaten, Thèse de doctorat, Fakultät für Mathematik und Physik, p.78, 1962. ,
CODA : convergence diagnosis and output analysis for MCMC, R News, vol.6, issue.1, pp.7-11, 2006. ,
Genome-scale models of microbial cells: evaluating the consequences of constraints, Nature Reviews Microbiology, vol.83, issue.11, pp.886-897, 2004. ,
DOI : 10.1074/jbc.M403782200
Uniform Sampling of Steady-State Flux Spaces: Means to Design Experiments and to Interpret Enzymopathies, Biophysical Journal, vol.87, issue.4, pp.2172-2186, 2004. ,
DOI : 10.1529/biophysj.104.043000
Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.274, issue.3, pp.695-704, 2001. ,
DOI : 10.1126/science.283.5407.1482
Flux balance analysis of biological systems : applications and challenges, Briefings in Bioinformatics, vol.10, issue.4, pp.435-449, 2009. ,
Characterization of 3-phosphoglycerate kinase from Corynebacterium glutamicum and its impact on amino acid production, BMC Microbiology, vol.14, issue.1, p.54, 2014. ,
DOI : 10.1186/1471-2180-14-54
Genome-Scale In Silico Models of E. coli Have Multiple Equivalent Phenotypic States: Assessment of Correlated Reaction Subsets That Comprise Network States, Genome Research, vol.14, issue.9, pp.1797-1805, 2004. ,
DOI : 10.1101/gr.2546004
Malate synthase from Corynebacterium glutamicum: sequence analysis of the gene and biochemical characterization of the enzyme, Microbiology, vol.140, issue.11, pp.3099-3108, 1994. ,
DOI : 10.1099/13500872-140-11-3099
Characterization of the phosphoenolpyruvate carboxykinase gene from Corynebacterium glutamicum and significance of the enzyme for growth and amino acid production Cité en, Journal of Molecular Microbiology and Biotechnology, vol.3, issue.4, pp.573-583, 2001. ,
Fructose-1,6-bisphosphatase from Corynebacterium glutamicum : expression and deletion of the fbp gene and biochemical characterization of the enzyme, Archives of Microbiology, vol.180, issue.4, pp.285-292, 2003. ,
DOI : 10.1007/s00203-003-0588-6
13C-NMR Studies of Corynebacterium melassecola Metabolic Pathways, European Journal of Biochemistry, vol.9, issue.1-2, pp.488-493, 1995. ,
DOI : 10.1007/978-1-4684-0465-4
Comparison of maintenance energy expenditures and growth yields among several rumen bacteria grown on continuous culture, Applied and Environmental Microbiology, vol.37, issue.3, pp.537-543, 1979. ,
Modeling of yeast metabolism and process dynamics in batch fermentation, Biotechnology and Bioengineering, vol.58, issue.7, pp.818-828, 2003. ,
DOI : 10.1002/(SICI)1097-0290(19980420)58:2/3<282::AID-BIT24>3.0.CO;2-D
Distinct roles of two anaplerotic pathways in glutamate production induced by biotin limitation in Corynebacterium glutamicum, Journal of Bioscience and Bioengineering, vol.106, issue.1, pp.51-58, 2008. ,
DOI : 10.1263/jbb.106.51
The PEP???pyruvate???oxaloacetate node as the switch point for carbon flux distribution in bacteria: We dedicate this paper to Rudolf K. Thauer, Director of the Max-Planck-Institute for Terrestrial Microbiology in Marburg, Germany, on the occasion of his 65th birthday, FEMS Microbiology Reviews, vol.29, issue.4, pp.765-794, 2005. ,
DOI : 10.1016/j.femsre.2004.11.002
Metabolic changes in a pyruvate kinase gene deletion mutant of Corynebacterium glutamicum ATCC 13032, Metabolic Engineering, vol.12, issue.4, pp.401-407, 2010. ,
DOI : 10.1016/j.ymben.2010.01.004
Use of Randomized Sampling for Analysis of Metabolic Networks, Journal of Biological Chemistry, vol.2, issue.9, pp.5457-5461, 2009. ,
DOI : 10.1038/nature02456
Genome-scale metabolic model of Helicobacter pylori 26695, Journal of Bacteriology, vol.184, issue.16, pp.4582-4593, 2002. ,
Pyruvate:Quinone Oxidoreductase from Corynebacterium glutamicum: Purification and Biochemical Characterization, Journal of Bacteriology, vol.187, issue.3, pp.862-871, 2005. ,
DOI : 10.1128/JB.187.3.862-871.2005
E1 Enzyme of the Pyruvate Dehydrogenase Complex in Corynebacterium glutamicum: Molecular Analysis of the Gene and Phylogenetic Aspects, Journal of Bacteriology, vol.187, issue.17, pp.6005-6018, 2005. ,
DOI : 10.1128/JB.187.17.6005-6018.2005
Pyruvate:Quinone Oxidoreductase in Corynebacterium glutamicum: Molecular Analysis of the pqo Gene, Significance of the Enzyme, and Phylogenetic Aspects, Journal of Bacteriology, vol.188, issue.4, pp.1341-1350, 2006. ,
DOI : 10.1128/JB.188.4.1341-1350.2006
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli, Molecular Systems Biology, vol.101, issue.119, pp.119-2007, 2007. ,
DOI : 10.1042/bj2380781
Multidimensional Optimality of Microbial Metabolism, Science, vol.224, issue.1, pp.601-604, 2012. ,
DOI : 10.1016/S0022-5193(03)00146-2
Is maximization of molar yield in metabolic networks favoured by evolution?, Journal of Theoretical Biology, vol.252, issue.3, pp.497-504, 2008. ,
DOI : 10.1016/j.jtbi.2007.12.008
Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data, Nature Genetics, vol.291, issue.2, pp.166-176, 2003. ,
DOI : 10.1038/35057062
Analysis of optimality in natural and perturbed metabolic networks, Proceedings of the National Academy of Sciences of the United States of America, pp.15112-15117, 2002. ,
DOI : 10.1002/1097-0290(20000920)69:6<664::AID-BIT11>3.0.CO;2-H
Effects of the changes in enzyme activities on metabolic flux redistribution around the 2-oxoglutarate branch in glutamate production by Corynebacterium glutamicum, Bioprocess and Biosystems Engineering, vol.67, issue.5, pp.291-298, 2003. ,
DOI : 10.1128/AEM.67.5.2310-2318.2001
Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum, Microbial Cell Factories, vol.8, issue.1, p.43, 2009. ,
DOI : 10.1186/1475-2859-8-43
Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria, Metabolic Engineering, vol.7, issue.2, pp.59-69, 2005. ,
DOI : 10.1016/j.ymben.2004.10.001
Regulatory on/off minimization of metabolic flux changes after genetic perturbations, Proceedings of the National Academy of Sciences, vol.235, issue.1, pp.7695-7700, 2005. ,
DOI : 10.1111/j.1574-6968.2004.tb09562.x
Qualitative modelling of regulated metabolic pathways: application to the tryptophan biosynthesis in E.Coli, Bioinformatics, vol.21, issue.Suppl 2, pp.190-196, 2005. ,
DOI : 10.1093/bioinformatics/bti1130
Towards a genome-scale kinetic model of cellular metabolism, BMC Systems Biology, vol.4, issue.1, pp.6-2010, 2010. ,
DOI : 10.1186/1752-0509-4-6
Efficient Monte Carlo Procedures for Generating Points Uniformly Distributed over Bounded Regions, Operations Research, vol.32, issue.6, pp.1296-1308, 1984. ,
DOI : 10.1287/opre.32.6.1296
Qualitative dynamics of piecewise-linear differential equations: a discrete mapping approach, Dynamics and Stability of Systems, vol.54, issue.3-4, pp.565-583, 1989. ,
DOI : 10.1016/S0006-3495(71)86192-1
Van den Meersche et D. van Oevelen. lim- Solve : solving linear inverse models, Package R, 2009. ,
Determination of the efficiency of oxidative phosphorylation in continuous cultures of Aerobacter aerogenes, Archives of Microbiology, vol.96, issue.1, pp.187-192, 1975. ,
DOI : 10.1007/BF00428367
Candidate Metabolic Network States in Human Mitochondria: IMPACT OF DIABETES, ISCHEMIA, AND DIET, Journal of Biological Chemistry, vol.280, issue.12, pp.11683-11695, 2005. ,
DOI : 10.1074/jbc.M409072200
Regulatory networks seen as asynchronous automata: A logical description, Journal of Theoretical Biology, vol.153, issue.1, pp.1-23, 1991. ,
DOI : 10.1016/S0022-5193(05)80350-9
Dynamic modeling of Escherichia coli metabolic and regulatory systems for amino-acid production, Journal of Biotechnology, vol.147, issue.1, pp.17-30, 2010. ,
DOI : 10.1016/j.jbiotec.2010.02.018
A method for the determination of pyruvate carboxylase activity during the glutamic acid fermentation with Corynebacterium glutamicum, Journal of Microbiological Methods, vol.39, issue.1, pp.91-96, 1999. ,
DOI : 10.1016/S0167-7012(99)00104-9
Metabolic flux distributions inCorynebacterium glutamicum during growth and lysine overproduction, Biotechnology and Bioengineering, vol.52, issue.6, pp.633-646, 1993. ,
DOI : 10.1271/bbb1961.52.455
xsample() : An R function for sampling linear inverse problems, Journal of Statistical Software, Code Snippets, vol.30, pp.1-15, 2009. ,
Quantifying food web flows using linear inverse models Cité en, Ecosystems, vol.136, issue.13 1, pp.110-142, 2010. ,
Citrate synthase in Corynebacterium glutamicum is encoded by two gltA transcripts which are controlled by RamA, RamB, and GlxR, Journal of Biotechnology, vol.154, issue.2-3, pp.140-148 ,
DOI : 10.1016/j.jbiotec.2010.07.004
Metabolic flux redistribution in Corynebacterium glutamicum in response to osmotic stress, Applied Microbiology and Biotechnology, vol.60, issue.5, pp.547-555, 2003. ,
DOI : 10.1007/s00253-002-1120-7
Osmotic Stress Response: Quantification of Cell Maintenance and Metabolic Fluxes in a Lysine-Overproducing Strain of Corynebacterium glutamicum, Applied and Environmental Microbiology, vol.70, issue.7, pp.4222-4229, 2004. ,
DOI : 10.1128/AEM.70.7.4222-4229.2004
Biochemical production capabilities ofescherichia coli, Biotechnology and Bioengineering, vol.260, issue.2, pp.59-73, 1993. ,
DOI : 10.1042/bj2380781
Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110, Références bibliographiques, pp.3724-3731, 1994. ,
Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum, Journal of Biotechnology, vol.140, issue.1-2, pp.75-83, 2009. ,
DOI : 10.1016/j.jbiotec.2008.12.014
Molecular cloning, nucleotide sequence and fine-structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1,6-biphosphate aldolase to class I and class II aldolases, Molecular Microbiology, vol.162, issue.11, pp.1625-1637, 1989. ,
DOI : 10.1007/BF00322452
Determination of flux through the branch point of two metabolic cycles. The tricarboxylic acid cycle and the glyoxylate shunt, The Journal of Biological Chemistry, vol.259, issue.15, pp.9646-9654, 1984. ,
A genome-scale metabolic flux model of Escherichia coli K???12 derived from the EcoCyc database, BMC Systems Biology, vol.8, issue.1, p.79, 2014. ,
DOI : 10.1186/1752-0509-8-79
Quantitative Determination of Metabolic Fluxes during Coutilization of Two Carbon Sources: Comparative Analyses with Corynebacterium glutamicum during Growth on Acetate and/or Glucose, Journal of Bacteriology, vol.182, issue.11, 2000. ,
DOI : 10.1128/JB.182.11.3088-3096.2000
13C Metabolic Flux Analysis, Metabolic Engineering, vol.3, issue.3, pp.195-206, 2001. ,
DOI : 10.1006/mben.2001.0187
Chromatin architecture and gene expression in Escherichia coli, Genome Biology, vol.5, issue.12, pp.252-265, 2004. ,
DOI : 10.1186/gb-2004-5-12-252
Metabolic Fluxes in Corynebacterium glutamicum during Lysine Production with Sucrose as Carbon Source, Applied and Environmental Microbiology, vol.70, issue.12, pp.7277-7287, 2004. ,
DOI : 10.1128/AEM.70.12.7277-7287.2004
Metabolic network analysis of lysine producingCorynebacterium glutamicum at a miniaturized scale, Biotechnology and Bioengineering, vol.68, issue.1, pp.1-6, 2004. ,
DOI : 10.1002/bit.20103
Comparative study of computational methods to detect the correlated reaction sets in biochemical networks, Briefings in Bioinformatics, vol.12, issue.2, pp.132-150, 2011. ,
DOI : 10.1093/bib/bbp068
A joint model of regulatory and metabolic networks, BMC Bioinformatics, vol.7, issue.1, pp.332-2006, 2006. ,
DOI : 10.1186/1471-2105-7-332
Maximal Sum of Metabolic Exchange Fluxes Outperforms Biomass Yield as a Predictor of Growth Rate of Microorganisms, PLoS ONE, vol.4, issue.5, pp.98372-2014, 2014. ,
DOI : 10.1371/journal.pone.0098372.s003
Genome-scale dynamic modeling of the competition between Rhodoferax and Geobacter in anoxic subsurface environments, The ISME Journal, vol.93, issue.2, pp.305-316, 2011. ,
DOI : 10.1016/j.jconhyd.2007.02.005
In Vitro Synthesis of Protein in Microbial Systems, Annual Review of Genetics, vol.7, issue.1, pp.267-287, 1973. ,
DOI : 10.1146/annurev.ge.07.120173.001411