Formulation et caractérisation de particules lipidiques submicroniques encapsulant des filtres ultraviolets organiques et inorganiques

Abstract : Sunscreens are topical formulations that protect the skin against damages induced by ultraviolet (UV) radiations and notably skin cancers formation. Those formulations contain organic and/or inorganic UV filters. Some organic UV filters are known to penetrate the skin and trigger allergic and photo-allergic cutaneous reactions. Moreover, some of them are responsible for toxic effects on skin nucleated cells and could reach systemic circulation. Nanoparticles of inorganic UV filters are often incorporated into sunscreens to improve their aesthetic qualities. Nanoparticles used as inorganic UV filters could exercise toxic effects on skin nucleated cells. Lipid nanoparticles and nanocapsules are submicronic lipid particles interesting to formulate pharmaceutical and cosmetic active compounds and notably UV filters. The aim of this work was to develop lipid nanoparticles to entrap organic and inorganic UV filters maintaining them at skin surface while increasing their photo-protection efficiency. This study permitted to develop lipid nanoparticle suspensions entrapping inorganic UV filters enhancing their photo-protection efficiency. This work also highlighted the interest of these lipid nanoparticle suspensions to entrap an organic UV filter avoiding its percutaneous permeation while enhancing its photo-protection efficiency
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Elodie Gilbert. Formulation et caractérisation de particules lipidiques submicroniques encapsulant des filtres ultraviolets organiques et inorganiques. Pharmacie galénique. Université Claude Bernard - Lyon I, 2015. Français. ⟨NNT : 2015LYO10324⟩. ⟨tel-01673835v2⟩

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