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Lithographic fabrication, electrical characterization and proof-of-concept demonstration of sensor circuits comprising organic electrochemical transistors for in vitro and in vivo diagnostics

Abstract : Due to their outstanding mechanical, electrical and chemical properties, organic electronic devices based on conducting polymers can bridge the gap between the rigid silicon based read-out electronics and the soft biological environment and will have a huge impact on the medical healthcare sector. The recent advances in the field of organic semiconductors and microelectronics gave rise to a new discipline termed bioelectronics. This discipline deals with sensors for diagnostic purposes, ranging from metabolite detection and DNA recognition all the way to single neuronal firing events, and actuators for therapeutic purposes, through for example active local drug delivery inside the body or deep brain stimulation to cure neurological disorder. The use of organic materials such as the conducting polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) in the field of bioelectronics has brought about a variety of outstanding electronic biomedical devices, such as the organic electrochemical transistor (OECT), that have been implemented for both in vitro and in vivo applications. The present manuscript gives a detailed explanation of the fabrication, functionalization and characterization of OECTs based on PEDOT:PSS. To be able to intercept this sensor element with traditional biomedical recording systems, the OECT is implemented into simple circuit layouts such as a voltage amplifier or a Wheatstone bridge. These sensor circuits are then applied to real-life biomedical challenges, such as electrocardiographic recordings or metabolite detection in tumor cell cultures, to demonstrate their applicability as well as their limitations.
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Submitted on : Friday, December 15, 2017 - 3:49:30 PM
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Marcel Braendlein. Lithographic fabrication, electrical characterization and proof-of-concept demonstration of sensor circuits comprising organic electrochemical transistors for in vitro and in vivo diagnostics. Other. Université de Lyon, 2017. English. ⟨NNT : 2017LYSEM007⟩. ⟨tel-01665192⟩

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