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Développement de procédés de mise en forme et de caractérisation pour l’élaboration de biocéramiques en apatites phosphocalciques carbonatées.

Abstract : The current approach to produce biomaterials tends to evolve due to societal change such as the development of personalized medicine or the eagerness to better understand bone biology. Hence, biomaterials, which specifications depends of their intended applications, have to be custom made. For bone tissue engineering, this implies to control the scaffold architecture and behaviour in a biological environment (e.g., biodegradability).Despite their indisputable qualities, the use of hydroxyapatite (HA) bioceramics tend to be limited to basic applications (e.g. filling small defects) because of biodegradation, osteoconduction, or osteoinduction properties that do not match the actual needs. To exceed these limitations, we explored two modifications paths to tune HA biologic properties: a “chemical” approach based on incorporation of carbonate ions into apatitic structure, and a “process” approach, built around additive manufacturing singular potential.Carbonated phosphocalcic hydroxyapatites (CHA) powders were prepared. As carbonate ions may occupy HA hydroxyl and phosphate sites, a selective method to quantify their ratio in each site by IR spectroscopy has been developed. This innovative spectroscopic method opens numerous opportunities for applied and fundamental studies of CHA, but could also be considered as a precious standard for a future release of CHA medical devices (e.g. ISO norm).A cheap, flexible, robust and reliable manufacturing process based on an additive manufacturing technology has been developed and optimized, leading to the production of bioceramics with complex architectural features (accuracy  5 µm).This manufacturing process has been implemented in biological studies with fundamental and therapeutic purposes.
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Submitted on : Friday, December 15, 2017 - 3:44:38 PM
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Baptiste Charbonnier. Développement de procédés de mise en forme et de caractérisation pour l’élaboration de biocéramiques en apatites phosphocalciques carbonatées.. Autre. Université de Lyon, 2016. Français. ⟨NNT : 2016LYSEM031⟩. ⟨tel-01665170⟩

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