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Impact des acariens et des micro-organismes de l'habitat dans le développement de l'asthme et de la broncho-pneumopathie chronique obstructive (BPCO)

Abstract : Our will to save energy leads us to live in a confined environment providing the ideal conditions to mites and microorganisms development. The aim of the thesis is to characterize mites and microorganisms contamination of dwellings from patients suffering respiratory diseases, to estimate the influence of the interactions between various organic communities on the allergens exposure and to understand the factors increasing the biological pollution ofindoor air. To evaluate our exposition, we needed to quantify mites and microorganisms with a common tool and an innovative quantification mode! of domestic mites by qPCR was developed. The presence of storage mites is overemphasized in dwellings of allergie patients and the eviction measures of mites should be applied into any rooms of dwellings. The contamination of dairy fanners' dwellings suffering from COPD was compared with that ofhealthy dairy fanners, COPC patients non-farmers and healthy non-fanners. In dwellings, the dairy fanners' exposure was important and specific ofth1 fanning environment. The lgG sensitivity to Wallemia sebi was significantly specific of dairy fanners suffering from COPD. The impact of the composting on the biological air quality was evaluated and the concentrations in storage mites and some molds increased significantly only in a confined area around the waste bin. New common indicators of domestic mites, molds and bacteria should allow us to progress in the determination of the dose-response relationship for the different allergens and their possible synergie effects.
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Submitted on : Thursday, December 14, 2017 - 2:26:17 PM
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  • HAL Id : tel-01664016, version 1

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Alexandre Naegele. Impact des acariens et des micro-organismes de l'habitat dans le développement de l'asthme et de la broncho-pneumopathie chronique obstructive (BPCO). Allergologie. Université de Franche-Comté, 2015. Français. ⟨NNT : 2015BESA3019⟩. ⟨tel-01664016⟩

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