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Functions of the transcription factor Lyl-1 in the development of the macrophage lineage

Abstract : Microglia are tissue macrophages (MΦ) of the central nervous system that control tissue homeostasis. Different fate mapping models have shown that microglia originates from the yolk sac (YS). Macrophages production in the YS occurs in two independent waves. In the first, primitive MΦ originate from restricted progenitors, while in the second, definitive MΦ are produced by erythro-myeloid progenitors. Because primitive and definitive MΦ progenitors share the same phenotype and differentiation pathway, their specific features and contribution to further developmental steps are still poorly understood. We here show that the expression of thee transcription factor Lyl-1 discriminates primitive and definitive MΦ populations. YS-derived Lyl-1+ primitive MΦ contribute to embryonic microglia. Moreover, Lyl-1 disruption results in an increased production of primitive MΦ progenitors in the early YS. It also leads to the reduction of the microglia pool at two specific development stages. Lyl-1 is specifically expressed in microglia, but not other brain cells and its inactivation leads to behavioral changes typical for social anxiety disorders. Thus, we identify Lyl-1 as a marker for YS primitive MΦ that will give rise to the entire microglia. We show that Lyl-1 controls microglia expansion and differentiation and is involved in the regulation of neurodevelopmental processes.
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Submitted on : Wednesday, December 13, 2017 - 4:50:09 PM
Last modification on : Wednesday, September 16, 2020 - 5:51:06 PM


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  • HAL Id : tel-01663080, version 1



Shoutang Wang. Functions of the transcription factor Lyl-1 in the development of the macrophage lineage. Embryology and Organogenesis. Université Paris Saclay (COmUE), 2017. English. ⟨NNT : 2017SACLS457⟩. ⟨tel-01663080⟩



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