. Muscle-constricteur-moy, D2% (Gy), p.761

J. Pignon, A. Le-maitre, E. Maillard, J. Bourhis, and M. Group, Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients, Radiotherapy and Oncology, vol.92, issue.1, pp.4-14, 2009.
DOI : 10.1016/j.radonc.2009.04.014

J. Pignon, A. Le-maitre, J. Bourhis, and M. Group, Meta-Analyses of Chemotherapy in Head and Neck Cancer (MACH-NC): An Update, International Journal of Radiation Oncology*Biology*Physics, vol.69, issue.2, 2007.
DOI : 10.1016/j.ijrobp.2007.04.088

D. Adelstein, P. Lavertu, J. Saxton, M. Secic, B. Wood et al., Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck. Cancer, Feb, vol.1588, issue.4, pp.876-83, 2000.

G. Calais, M. Alfonsi, E. Bardet, C. Sire, T. Germain et al., Randomized Trial of Radiation Therapy Versus Concomitant Chemotherapy and Radiation Therapy for Advanced-Stage Oropharynx Carcinoma, JNCI: Journal of the National Cancer Institute, vol.91, issue.24, pp.2081-2087, 1999.
DOI : 10.1093/jnci/91.24.2081

D. Adelstein, Y. Li, G. Adams, H. Wagner, J. Kish et al., An Intergroup Phase III Comparison of Standard Radiation Therapy and Two Schedules of Concurrent Chemoradiotherapy in Patients With Unresectable Squamous Cell Head and Neck Cancer, Journal of Clinical Oncology, vol.21, issue.1, pp.92-100, 2003.
DOI : 10.1200/JCO.2003.01.008

T. Wendt, G. Grabenbauer, C. Rodel, H. Thiel, H. Aydin et al., Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study., Journal of Clinical Oncology, vol.16, issue.4, pp.1318-1342, 1998.
DOI : 10.1200/JCO.1998.16.4.1318

M. Merlano, M. Benasso, R. Corvo, R. Rosso, V. Vitale et al., Five-Year Update of a Randomized Trial of Alternating Radiotherapy and Chemotherapy Compared With Radiotherapy Alone in Treatment of Unresectable Squamous Cell Carcinoma of the Head and Neck, JNCI Journal of the National Cancer Institute, vol.88, issue.9, pp.583-592, 1996.
DOI : 10.1093/jnci/88.9.583

J. Bonner, P. Harari, J. Giralt, N. Azarnia, D. Shin et al., Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck, New England Journal of Medicine, vol.354, issue.6, pp.567-78, 2006.
DOI : 10.1056/NEJMoa053422

P. Huguenin, D. Taussky, K. Moe, A. Meister, B. Baumert et al., Quality of life in patients cured from a carcinoma of the head and neck by radiotherapy: the importance of the target volume, International Journal of Radiation Oncology*Biology*Physics, vol.45, issue.1, pp.47-52, 1999.
DOI : 10.1016/S0360-3016(99)00128-5

C. Nutting, J. Morden, K. Harrington, T. Urbano, S. Bhide et al., Parotidsparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial, Lancet Oncol, 2011.

M. Lapeyre, V. Marchesi, A. Mege, P. Aletti, P. Graff et al., Intensity-modulated radiation therapy for head and neck cancers with bilateral irradiation of the neck : preliminary results]. Cancer Radiother, pp.134-181, 2004.

C. Marchal, M. Lapeyre, V. Beckendorf, P. Aletti, E. Hasle et al., Preliminary results of the assessment of intensity modulated radiotherapy (IMRT) for prostatic and head and neck tumors, Cancer Radiother, pp.121-128, 2001.

S. Supiot, A. Lisbona, F. Paris, D. Azria, and P. Fenoglietto, Dose-painting": myth or reality?]. Cancer Radiother, pp.6-7554, 2010.

A. Brahme, Dosimetric Precision Requirements in Radiation Therapy, Acta Radiologica: Oncology, vol.54, issue.5, pp.379-91, 1984.
DOI : 10.1259/0007-1285-54-647-1012

J. Deasy, Multiple local minima in radiotherapy optimization problems with dosevolume constraints. Med Phys, pp.1157-61, 1997.

A. Niemierko and M. Goitein, Calculation of normal tissue complication probability and dose-volume histogram reduction schemes for tissues with a critical element architecture, Radiotherapy and Oncology, vol.20, issue.3, pp.166-76, 1991.
DOI : 10.1016/0167-8140(91)90093-V

H. Johns, . Wg, T. Watson, and F. Umberg, A system of dosimetry for rotation therapy with typical rotation distributions, Can Assoc Radiol J, vol.4, 1953.

A. Brahme, J. Roos, and I. Lax, Solution of an integral equation encountered in rotation therapy, Physics in Medicine and Biology, vol.27, issue.10, pp.1221-1230, 1982.
DOI : 10.1088/0031-9155/27/10/002

L. Chin, P. Kijewski, G. Svensson, and B. Bjarngard, Dose optimization with computer-controlled gantry rotation, collimator motion and dose-rate variation, International Journal of Radiation Oncology*Biology*Physics, vol.9, issue.5, pp.723-732, 1983.
DOI : 10.1016/0360-3016(83)90241-9

C. Yu, M. Symons, M. Du, A. Martinez, and J. Wong, A method for implementing dynamic photon beam intensity modulation using independent jaws and a multileaf collimator, Physics in Medicine and Biology, vol.40, issue.5, pp.769-87, 1995.
DOI : 10.1088/0031-9155/40/5/005

C. Yu, Intensity-modulated arc therapy with dynamic multileaf collimation: an alternative to tomotherapy, Physics in Medicine and Biology, vol.40, issue.9, pp.1435-1484, 1995.
DOI : 10.1088/0031-9155/40/9/004

K. Otto, Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys, 2008.

E. Vanetti, G. Nicolini, J. Nord, J. Peltola, A. Clivio et al., On the role of the optimization algorithm of RapidArc((R)) volumetric modulated arc therapy on plan quality and efficiency. Med Phys, pp.5844-56, 2011.

C. Bragg and J. Conway, Dosimetric verification of the anisotropic analytical algorithm for radiotherapy treatment planning, Radiotherapy and Oncology, vol.81, issue.3, pp.315-338, 2006.
DOI : 10.1016/j.radonc.2006.10.020

A. Van-esch, L. Tillikainen, J. Pyykkonen, M. Tenhunen, H. Helminen et al., Testing of the analytical anisotropic algorithm for photon dose calculation, Medical Physics, vol.73, issue.3, 2006.
DOI : 10.1016/j.radonc.2004.06.007

A. Ahnesjo, L. Weber, A. Murman, M. Saxner, I. Thorslund et al., Beam modeling and verification of a photon beam multisource model. Med Phys, pp.1722-1759, 2005.

L. Tillikainen, S. Siljamaki, H. Helminen, J. Alakuijala, and J. Pyyry, Determination of parameters for a multiple-source model of megavoltage photon beams using optimization methods, Physics in Medicine and Biology, vol.52, issue.5
DOI : 10.1088/0031-9155/52/5/015

W. Ulmer, J. Pyyry, and W. Kaissl, A 3D photon superposition/convolution algorithm and its foundation on results of Monte Carlo calculations, Physics in Medicine and Biology, vol.50, issue.8, pp.1767-90, 2005.
DOI : 10.1088/0031-9155/50/8/010

H. Liu, T. Mackie, and E. Mccullough, A dual source photon beam model used in convolution/superposition dose calculations for clinical megavoltage x-ray beams. Med Phys, pp.1960-74, 1997.

D. Rogers, B. Faddegon, G. Ding, C. Ma, J. We et al., BEAM: a Monte Carlo code to simulate radiotherapy treatment units. Med Phys, pp.503-527, 1995.

W. Ulmer and W. Kaissl, The inverse problem of a Gaussian convolution and its application to the finite size of the measurement chambers

J. Sieven, . Uw, and W. Kaissi, AAA Photon Dose calculation model in Eclipse

M. Kathirvel, S. Subramanian, A. Clivio, G. Arun, A. Fogliata et al., Critical appraisal of the accuracy of Acuros-XB and Anisotropic Analytical Algorithm compared to measurement and calculations with the compass system in the delivery of RapidArc clinical plans, Radiation Oncology, vol.8, issue.1, p.140, 2013.
DOI : 10.1016/j.ijrobp.2011.10.078

M. Tomsej, The TomoTherapy HiArt System for sophisticated IMRT and IGRT with helical delivery: Recent developments and clinical applications]. Cancer Radiother, 2006.

C. Dejean, G. Kantor, H. De-figueiredo, B. Lisbona, A. Mahe et al., Helical tomotherapy: description and clinical applications]. Bull Cancer, pp.783-792, 2010.

W. Lu, G. Olivera, M. Chen, P. Reckwerdt, and T. Mackie, Accurate convolution/superposition for multi-resolution dose calculation using cumulative tabulated kernels, Physics in Medicine and Biology, vol.50, issue.4, pp.655-80, 2005.
DOI : 10.1088/0031-9155/50/4/007

Q. Chen, W. Lu, Y. Chen, M. Chen, D. Henderson et al., Validation of GPU based TomoTherapy dose calculation engine, Medical Physics, vol.17, issue.4, pp.1877-86
DOI : 10.1118/1.596497

Q. Chen, M. Chen, and W. Lu, Ultrafast convolution/superposition using tabulated and exponential kernels on GPU. Med Phys, pp.1150-61, 2011.

R. Mohan, C. Chui, and L. Lidofsky, Differential pencil beam dose computation model for photons. Med Phys, pp.64-73, 1986.

T. Mackie, J. Scrimger, and J. Battista, A convolution method of calculating dose for 15- MV x rays. Med Phys, pp.188-96, 1985.

A. Boyer and E. Mok, A photon dose distribution model employing convolution calculations, Medical Physics, vol.12, issue.2
DOI : 10.1118/1.595772

A. Ahnesjo, Collapsed cone convolution of radiant energy for photon dose calculation in heterogeneous media. Med Phys, pp.577-92, 1989.

P. Metcalfe, P. Hoban, D. Murray, and W. Round, Beam hardening of 10 MV radiotherapy X-rays: analysis using a convolution/superposition method, Physics in Medicine and Biology, vol.35, issue.11, pp.1533-1582, 1990.
DOI : 10.1088/0031-9155/35/11/008

N. Papanikolaou, T. Mackie, C. Meger-wells, M. Gehring, and P. Reckwerdt, Investigation of the convolution method for polyenergetic spectra. Med Phys, pp.1327-1363, 1993.

H. Liu, T. Mackie, and E. Mccullough, Correcting kernel tilting and hardening in convolution/superposition dose calculations for clinical divergent and polychromatic photon beams. Med Phys, pp.1729-1770, 1997.

O. Connor and J. , The density scaling theorem applied to lateral electronic equilibrium. Med Phys, pp.678-80, 1984.

P. Mayles and A. , Handbook of radiotherapy physics. Theory and Pratice

K. Ruchala, G. Olivera, E. Schloesser, and T. Mackie, Megavoltage CT on a tomotherapy system, Physics in Medicine and Biology, vol.44, issue.10, pp.2597-621, 1999.
DOI : 10.1088/0031-9155/44/10/316

N. Rezvoy and B. Dubray, Probabilities of organs at risk damage: history and mathematical models]. Cancer Radiother, pp.4-5241, 2010.

P. Mayles and A. , Handbook of radiotherapy physics. Theory and Pratice

V. Semenenko and X. Li, Lyman???Kutcher???Burman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data, Physics in Medicine and Biology, vol.53, issue.3, pp.737-55, 2008.
DOI : 10.1088/0031-9155/53/3/014

J. Lyman, Normal tissue complication probabilities: Variable dose per fraction, International Journal of Radiation Oncology*Biology*Physics, vol.22, issue.2, pp.247-50, 1992.
DOI : 10.1016/0360-3016(92)90040-O

C. Burman, G. Kutcher, B. Emami, and M. Goitein, Fitting of normal tissue tolerance data to an analytic function, International Journal of Radiation Oncology*Biology*Physics, vol.21, issue.1, pp.123-158, 1991.
DOI : 10.1016/0360-3016(91)90172-Z

J. Roesink, M. Moerland, J. Battermann, G. Hordijk, and C. Terhaard, Qantitative dose-volume response analysis of changes in parotid gland function after radiotheraphy in the head-and-neck region, International Journal of Radiation Oncology*Biology*Physics, vol.51, issue.4, pp.938-984, 2001.
DOI : 10.1016/S0360-3016(01)01717-5

J. Roesink, M. Moerland, A. Hoekstra, P. Van-rijk, and C. Terhaard, Scintigraphic assessment of early and late parotid gland function after radiotherapy for head-and-neck cancer: a prospective study of dose???volume response relationships, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.5, pp.1451-60, 2004.
DOI : 10.1016/j.ijrobp.2003.09.021

W. Chen, C. Lai, T. Lee, C. Hung, K. Liu et al., Scintigraphic assessment of salivary function after intensity-modulated radiotherapy for head and neck cancer: Correlations with parotid dose and quality of life, Oral Oncology, vol.49, issue.1, pp.42-50, 2013.
DOI : 10.1016/j.oraloncology.2012.07.004

A. Niemierko, Reporting and analyzing dose distributions: A concept of equivalent uniform dose, Medical Physics, vol.42, issue.1, pp.103-113, 1997.
DOI : 10.1259/0007-1285-42-504-925

C. Thieke, T. Bortfeld, A. Niemierko, and S. Nill, From physical dose constraints to equivalent uniform dose constraints in inverse radiotherapy planning. Med Phys, pp.2332-2341, 2003.

J. Lyman, Complication Probability as Assessed from Dose-Volume Histograms, Radiation Research Supplement, vol.8, pp.13-22, 1985.
DOI : 10.2307/3583506

R. Mohan, G. Mageras, B. Baldwin, L. Brewster, G. Kutcher et al., Clinically relevant optimization of 3-D conformal treatments. Med Phys, pp.933-977, 1992.

R. Oozeer, B. Chauvet, R. Garcia, C. Berger, C. Felix-faure et al., Dosimetric evaluation of conformal radiotherapy: conformity factor]. Cancer Radiother, pp.207-223, 2000.

L. Feuvret, G. Noel, C. Nauraye, P. Garcia, and J. J. , Conformal index and radiotherapy]. Cancer Radiother, pp.108-127, 2004.

C. Chargari and J. Cosset, [The issue of low doses in radiation therapy and impact on radiation-induced secondary malignancies]. Bull Cancer, pp.1333-1375, 2013.

J. Cosset, M. Henry-amar, P. Dietrich, G. Socie, T. Girinsky et al., Secondary solid tumors after Hodgkin's disease radiotherapy; experience at the Gustave Roussy Institute], Bull Cancer, vol.79, issue.4, pp.387-395, 1992.

E. Hall and C. Wuu, Radiation-induced second cancers: the impact of 3D-CRT and IMRT, International Journal of Radiation Oncology*Biology*Physics, vol.56, issue.1, pp.83-91, 2003.
DOI : 10.1016/S0360-3016(03)00073-7

H. Aoyama, D. Westerly, T. Mackie, G. Olivera, S. Bentzen et al., Integral radiation dose to normal structures with conformal external beam radiation, International Journal of Radiation Oncology*Biology*Physics, vol.64, issue.3, pp.962-969, 2006.
DOI : 10.1016/j.ijrobp.2005.11.005

D. Souza, W. Rosen, and I. , Nontumor integral dose variation in conventional radiotherapy treatment planning, Medical Physics, vol.33, issue.8, pp.2065-71, 2003.
DOI : 10.1016/0360-3016(95)00113-D

B. Bussels, A. Maes, P. Flamen, P. Lambin, K. Erven et al., Dose???response relationships within the parotid gland after radiotherapy for head and neck cancer, Radiotherapy and Oncology, vol.73, issue.3
DOI : 10.1016/j.radonc.2004.09.015

B. Bussels, A. Maes, R. Hermans, S. Nuyts, C. Weltens et al., Recurrences after conformal parotid-sparing radiotherapy for head and neck cancer. Radiother Oncol, pp.119-146, 2004.

V. Gregoire, K. Ang, W. Budach, C. Grau, M. Hamoir et al., Delineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines, Radiotherapy and Oncology, vol.110, issue.1, pp.172-81, 2014.
DOI : 10.1016/j.radonc.2013.10.010

K. Abok, U. Brunk, B. Jung, and J. Ericsson, Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland, Virchows Archiv B Cell Pathology Including Molecular Pathology, vol.99, issue.1, pp.443-60, 1984.
DOI : 10.1042/bj0990657

R. Coppes, A. Roffel, L. Zeilstra, A. Vissink, and A. Konings, Early Radiation Effects on Muscarinic Receptor-Induced Secretory Responsiveness of the Parotid Gland in the Freely Moving Rat, Radiation Research, vol.153, issue.3, pp.339-385, 2000.
DOI : 10.1667/0033-7587(2000)153[0339:EREOMR]2.0.CO;2

K. Takagi, K. Yamaguchi, T. Sakurai, T. Asari, K. Hashimoto et al., Secretion of Saliva in X-Irradiated Rat Submandibular Glands, Radiation Research, vol.159, issue.3, pp.351-60, 2003.
DOI : 10.1667/0033-7587(2003)159[0351:SOSIXI]2.0.CO;2

R. Coppes, L. Zeilstra, H. Kampinga, and A. Konings, Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonists, British Journal of Cancer, vol.37, issue.7, pp.1055-63, 2001.
DOI : 10.1016/S0360-3016(96)00557-3

J. Li, Z. Shan, G. Ou, X. Liu, C. Zhang et al., Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig, International Journal of Radiation Oncology*Biology*Physics, vol.62, issue.5, pp.1510-1516, 2005.
DOI : 10.1016/j.ijrobp.2005.04.029

C. Eneroth, C. Henrikson, and P. Jakobsson, Pre-Irradiation Qualities of a Parotid Gland Predicting the Grade of Functional Disturbance by Radiotherapy, Acta Oto-Laryngologica, vol.77, issue.1-6, 1972.
DOI : 10.1037/h0073282

M. Navazesh and S. Kumar, University of Southern California School of D. Measuring salivary flow: challenges and opportunities. J Am Dent Assoc, pp.35-40, 2008.

A. Wolff, A. Begleiter, and D. Moskona, A Novel System of Human Submandibular/Sublingual Saliva Collection, Journal of Dental Research, vol.1, issue.11, pp.1782-1788, 1997.
DOI : 10.1016/0030-4220(93)90258-6

P. Fox, P. Van-der-ven, B. Sonies, J. Weiffenbach, and B. Baum, Xerostomia: evaluation of a symptom with increasing significance, The Journal of the American Dental Association, vol.110, issue.4, pp.519-544, 1985.
DOI : 10.14219/jada.archive.1985.0384

K. Ogami, K. Sakurai, and T. Ando, A method of measuring salivary flow rate in the lower labial mucosal region, Journal of Oral Rehabilitation, vol.31, issue.9, pp.861-866, 2004.
DOI : 10.1111/j.1365-2842.2004.01319.x

J. Roesink and C. Terhaard, The influence of clinical factors on human stimulated parotid flow rate in cancer and other patients, Oral Oncology, vol.38, issue.3, pp.291-296, 2002.
DOI : 10.1016/S1368-8375(01)00058-6

F. Burlage, J. Pijpe, R. Coppes, M. Hemels, H. Meertens et al., Variability of flow rate when collecting stimulated human parotid saliva, European Journal of Oral Sciences, vol.60, issue.5, 2005.
DOI : 10.1007/s007840000077

R. Valdes-olmos, R. Keus, R. Takes, H. Van-tinteren, G. Baris et al., Scintigraphic assessment of salivary function and excretion response in radiation-induced injury of the major salivary glands. Cancer, pp.2886-93, 1994.

W. Kohn, J. Ship, J. Atkinson, L. Patton, and P. Fox, Salivary gland 99mTc-scintigraphy: a grading scale and correlation with major salivary gland flow rates, Journal of Oral Pathology and Medicine, vol.169, issue.2, 1992.
DOI : 10.1177/00220345840630100101

M. Kaneko, H. Shirato, T. Nishioka, K. Ohmori, S. Takinami et al., Scintigraphic evaluation of long-term salivary function after bilateral whole parotid gland irradiation in radiotherapy for head and neck tumour, Oral Oncology, vol.34, issue.2, pp.140-146, 1998.
DOI : 10.1016/S1368-8375(97)00087-0

M. Munter, C. Karger, S. Hoffner, H. Hof, C. Thilmann et al., Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.1, 2004.
DOI : 10.1016/S0360-3016(03)01437-8

M. Leslie and S. Dische, The early changes in salivary gland function during and after radiotherapy given for head and neck cancer. Radiother Oncol, pp.26-32, 1994.

J. Marks, C. Davis, V. Gottsman, J. Purdy, and F. Lee, The effects of radiation on parotid salivary function, International Journal of Radiation Oncology*Biology*Physics, vol.7, issue.8, pp.1013-1022, 1981.
DOI : 10.1016/0360-3016(81)90152-8

B. Emami, J. Lyman, A. Brown, L. Coia, M. Goitein et al., Tolerance of normal tissue to therapeutic irradiation, International Journal of Radiation Oncology*Biology*Physics, vol.21, issue.1, pp.109-131, 1991.
DOI : 10.1016/0360-3016(91)90171-Y

A. Eisbruch, H. Kim, J. Terrell, L. Marsh, L. Dawson et al., Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.50, issue.3, pp.695-704, 2001.
DOI : 10.1016/S0360-3016(01)01512-7

T. Van-de-water, H. Bijl, H. Westerlaan, and J. Langendijk, Delineation guidelines for organs at risk involved in radiation-induced salivary dysfunction and xerostomia, Radiotherapy and Oncology, vol.93, issue.3, pp.545-52, 2009.
DOI : 10.1016/j.radonc.2009.09.008

F. Hoebers, E. Yu, A. Eisbruch, W. Thorstad, O. Sullivan et al., A Pragmatic Contouring Guideline for Salivary Gland Structures in Head and Neck Radiation Oncology, American Journal of Clinical Oncology, vol.36, issue.1, pp.70-76, 2013.
DOI : 10.1097/COC.0b013e31823a538e

Y. Sun, X. Yu, W. Luo, A. Lee, J. Wee et al., Recommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy, Radiotherapy and Oncology, vol.110, issue.3, pp.390-397, 2014.
DOI : 10.1016/j.radonc.2013.10.035

M. Christianen, J. Langendijk, H. Westerlaan, T. Van-de-water, and H. Bijl, Delineation of organs at risk involved in swallowing for radiotherapy treatment planning, Radiotherapy and Oncology, vol.101, issue.3, pp.394-402, 2011.
DOI : 10.1016/j.radonc.2011.05.015

A. Eisbruch, T. Haken, R. Kim, H. Marsh, L. Ship et al., Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.45, issue.3, pp.577-87, 1999.
DOI : 10.1016/S0360-3016(99)00247-3

K. Chao, . Dj, J. Markman, J. Haynie, C. Perez et al., A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results, International Journal of Radiation Oncology*Biology*Physics, vol.49, issue.4, pp.907-923, 2001.
DOI : 10.1016/S0360-3016(00)01441-3

Y. Li, J. Taylor, T. Haken, R. Eisbruch, and A. , The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.3, pp.660-669, 2007.
DOI : 10.1016/j.ijrobp.2006.09.021

A. Eisbruch, Reducing Xerostomia by IMRT: What May, and May Not, Be Achieved, Journal of Clinical Oncology, vol.25, issue.31, pp.4863-4867, 2007.
DOI : 10.1200/JCO.2007.13.4874

C. Murdoch-kinch, H. Kim, K. Vineberg, J. Ship, and A. Eisbruch, Dose-Effect Relationships for the Submandibular Salivary Glands and Implications for Their Sparing by Intensity Modulated Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.72, issue.2, pp.373-82, 2008.
DOI : 10.1016/j.ijrobp.2007.12.033

I. Beetz, C. Schilstra, A. Visink, A. Van-der-schaaf, H. Bijl et al., Role of minor salivary glands in developing patient-rated xerostomia and sticky saliva during day and night, Radiotherapy and Oncology, vol.109, issue.2, pp.311-317, 2013.
DOI : 10.1016/j.radonc.2013.06.040

M. Little, M. Schipper, F. Feng, K. Vineberg, C. Cornwall et al., Reducing Xerostomia After Chemo-IMRT for Head-and-Neck Cancer: Beyond Sparing the Parotid Glands, International Journal of Radiation Oncology*Biology*Physics, vol.83, issue.3, pp.1007-1021, 2012.
DOI : 10.1016/j.ijrobp.2011.09.004

C. Ortholan, E. Chamorey, K. Benezery, J. Thariat, O. Dassonville et al., Modeling of Salivary Production Recovery After Radiotherapy Using Mixed Models: Determination of Optimal Dose Constraint for IMRT Planning and Construction of Convenient Tools to Predict Salivary Function, International Journal of Radiation Oncology*Biology*Physics, vol.73, issue.1, pp.178-86, 2009.
DOI : 10.1016/j.ijrobp.2008.03.068

Y. Abo-madyan, M. Aziz, M. Aly, F. Schneider, E. Sperk et al., Second cancer risk after 3D-CRT, IMRT and VMAT for breast cancer. Radiother Oncol, 2014.

S. Yartsev, L. Muren, and D. Thwaites, Treatment planning studies in radiotherapy, Radiotherapy and Oncology, vol.109, issue.3, pp.342-345, 2013.
DOI : 10.1016/j.radonc.2013.11.008

M. Lapeyre, I. Toledano, N. Bourry, C. Bailly, and F. Cachin, Target volume delineation for head and neck cancer intensity-modulated radiotherapy]. Cancer Radiother, pp.6-7466, 2011.

L. Peters, O. Sullivan, B. Giralt, J. Fitzgerald, T. Trotti et al., Critical Impact of Radiotherapy Protocol Compliance and Quality in the Treatment of Advanced Head and Neck Cancer: Results From TROG 02.02, Journal of Clinical Oncology, vol.28, issue.18, pp.2996-3001, 2010.
DOI : 10.1200/JCO.2009.27.4498

O. Eojc, Introducing new treatments and technologies into the Clinic, J Clin Oncol, vol.26, p.2426, 2008.

M. Lapeyre, M. Zlfonsi, E. Bardet, R. J. Bensadoun, G. Dolivet et al., Proposition de s??lection et d??limitation des volumes cibles microscopiques p??ritumoraux dans les cancers de la cavit?? buccale et de l'oropharynx (aires ganglionnaires exclues), Cancer/Radioth??rapie, vol.9, issue.4, pp.261-70, 2005.
DOI : 10.1016/j.canrad.2005.03.005

V. Gregoire, . Ce, G. Cosnard, M. Hamoir, and H. Reychler, Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience, Radiotherapy and Oncology, vol.56, issue.2, pp.135-50, 2000.
DOI : 10.1016/S0167-8140(00)00202-4

P. Andreo, D. , K. Hohlfeld, T. J. Huq, T. Kanai et al., IAEA TRS-398 Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry based, 2006.

S. Marcié, . Ap, D. Lefkopoulos, and M. Tomsej, Programme commun d???assurance de qualit?? de la radioth??rapie conformationnelle avec modulation d???intensit?? (RCMI) des cancers de la t??te et du cou, Cancer/Radioth??rapie, vol.7, issue.3, pp.172-180, 2003.
DOI : 10.1016/S1278-3218(03)00016-7

A. Shakam, R. Scrimger, D. Liu, M. Mohamed, M. Parliament et al., Dose???volume analysis of locoregional recurrences in head and neck IMRT, as determined by deformable registration: A prospective multi-institutional trial, Radiotherapy and Oncology, vol.99, issue.2, pp.101-108, 2011.
DOI : 10.1016/j.radonc.2011.05.008

M. Daly, Q. Le, M. Kozak, P. Maxim, J. Murphy et al., Intensity-Modulated Radiotherapy for Oral Cavity Squamous Cell Carcinoma: Patterns of Failure and Predictors of Local Control, International Journal of Radiation Oncology*Biology*Physics, vol.80, issue.5, pp.1412-1434, 2011.
DOI : 10.1016/j.ijrobp.2010.04.031

M. Daly, Q. Le, P. Maxim, B. Loo, J. Kaplan et al., Intensity-Modulated Radiotherapy in the Treatment of Oropharyngeal Cancer: Clinical Outcomes and Patterns of Failure, International Journal of Radiation Oncology*Biology*Physics, vol.76, issue.5, pp.1339-1385, 2010.
DOI : 10.1016/j.ijrobp.2009.04.006

L. Dawson, Y. Anzai, L. Marsh, M. Martel, A. Paulino et al., Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.46, issue.5, pp.1117-1143, 2000.
DOI : 10.1016/S0360-3016(99)00550-7

K. Chao, G. Ozyigit, B. Tran, M. Cengiz, J. Dempsey et al., Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer, International Journal of Radiation Oncology*Biology*Physics, vol.55, issue.2, pp.312-333, 2003.
DOI : 10.1016/S0360-3016(02)03940-8

P. Castadot, X. Geets, J. Lee, N. Christian, and V. Gregoire, Assessment by a deformable registration method of the volumetric and positional changes of target volumes and organs at risk in pharyngo-laryngeal tumors treated with concomitant chemo-radiation, Radiotherapy and Oncology, vol.95, issue.2, pp.209-226, 2010.
DOI : 10.1016/j.radonc.2010.03.007

G. Marta, V. Silva, H. De-andrade-carvalho, F. De-arruda, S. Hanna et al., Intensity-modulated radiation therapy for head and neck cancer: Systematic review and meta-analysis, Radiotherapy and Oncology, vol.110, issue.1, pp.9-15, 2014.
DOI : 10.1016/j.radonc.2013.11.010

M. Kam, S. Leung, B. Zee, R. Chau, J. Suen et al., Prospective Randomized Study of Intensity-Modulated Radiotherapy on Salivary Gland Function in Early-Stage Nasopharyngeal Carcinoma Patients, Journal of Clinical Oncology, vol.25, issue.31, pp.4873-4882, 2007.
DOI : 10.1200/JCO.2007.11.5501

T. Gupta, J. Agarwal, S. Jain, R. Phurailatpam, S. Kannan et al., Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: A randomized controlled trial, Radiotherapy and Oncology, vol.104, issue.3, pp.343-351, 2012.
DOI : 10.1016/j.radonc.2012.07.001

G. Peng, T. Wang, K. Yang, S. Zhang, T. Zhang et al., A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma, Radiotherapy and Oncology, vol.104, issue.3, pp.286-93, 2012.
DOI : 10.1016/j.radonc.2012.08.013

P. Dirix, D. Keyzer, F. Vandecaveye, V. Stroobants, S. Hermans et al., Diffusion-Weighted Magnetic Resonance Imaging to Evaluate Major Salivary Gland Function Before and After Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.71, issue.5, pp.1365-71, 2008.
DOI : 10.1016/j.ijrobp.2007.12.011

M. Munter, S. Hoffner, H. Hof, K. Herfarth, U. Haberkorn et al., Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: Comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.3, pp.651-660, 2007.
DOI : 10.1016/j.ijrobp.2006.09.035

M. Voordeckers, H. Everaert, K. Tournel, D. Verellen, I. Baron et al., Longitudinale Absch??tzung der Speicheldr??senfunktion bei Patienten mit helikaler Tomotherapie von Kopf-Hals-Tumoren, Strahlentherapie und Onkologie, vol.184, issue.8, pp.400-405, 2008.
DOI : 10.1007/s00066-008-1836-0

V. Rudat, M. Munter, D. Rades, K. Grotz, A. Bajrovic et al., The effect of amifostine or IMRT to preserve the parotid function after radiotherapy of the head and neck region measured by quantitative salivary gland scintigraphy, Radiother Oncol, 2008.

J. Hey, J. Setz, R. Gerlach, M. Janich, G. Hildebrandt et al., Parotid gland-recovery after radiotherapy in the head and neck region - 36 months follow-up of a prospective clinical study, Radiation Oncology, vol.6, issue.1, p.125, 2011.
DOI : 10.1177/00220345750540040801

J. Cox, J. Stetz, and T. Pajak, Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC), International Journal of Radiation Oncology*Biology*Physics, vol.31, issue.5, pp.1341-1347, 1995.
DOI : 10.1016/0360-3016(95)00060-C

A. Miah, S. Gulliford, C. Clark, S. Bhide, S. Zaidi et al., Dose-response analysis of parotid gland function: what is the best measure of xerostomia? Radiother Oncol, pp.341-346, 2013.

P. Rubin, L. Constine, L. Fajardo, T. Phillips, and T. Wasserman, Overview: Late effects of normal tissues (LENT) scoring system, International Journal of Radiation Oncology*Biology*Physics, vol.31, issue.5, pp.1041-1043, 1995.
DOI : 10.1016/0360-3016(95)00057-6

P. Rubin, L. Constine, L. Fajardo, T. Phillips, and T. Wasserman, Overview of late effects normal tissues (LENT) scoring system, Radiotherapy and Oncology, vol.35, issue.1, pp.9-10, 1995.
DOI : 10.1016/0167-8140(95)97447-L

A. Eisbruch, N. Rhodus, D. Rosenthal, B. Murphy, C. Rasch et al., How should we measure and report radiotherapy-induced xerostomia? Semin Radiat Oncol, 2003.

T. Lee, P. Chao, H. Wang, H. Hsu, P. Chang et al., Normal tissue complication probability model parameter estimation for xerostomia in head and neck cancer patients based on scintigraphy and quality of life assessments, BMC Cancer, vol.47, issue.1, p.567, 2012.
DOI : 10.1016/j.oraloncology.2011.05.012

J. Roesink, M. Schipper, W. Busschers, C. Raaijmakers, and C. Terhaard, A comparison of mean parotid gland dose with measures of parotid gland function after radiotherapy for head-and-neck cancer: Implications for future trials, International Journal of Radiation Oncology*Biology*Physics, vol.63, issue.4, pp.1006-1015, 2005.
DOI : 10.1016/j.ijrobp.2005.04.023

T. Perneger and A. Perrier, Analyse d???un test diagnostique : courbe ROC, ou ?? receiver operating characteristic ??, Revue des Maladies Respiratoires, vol.21, issue.2, pp.398-401
DOI : 10.1016/S0761-8425(04)71302-9

R. Scrimger, P. Stavrev, M. Parliament, C. Field, H. Thompson et al., Phenomenologic model describing flow reduction for parotid gland irradiation with intensity-modulated radiotherapy: Evidence of significant recovery effect, International Journal of Radiation Oncology*Biology*Physics, vol.60, issue.1, pp.178-85, 2004.
DOI : 10.1016/j.ijrobp.2004.02.041

T. Lee, P. Chao, H. Ting, L. Chang, Y. Huang et al., Using Multivariate Regression Model with Least Absolute Shrinkage and Selection Operator (LASSO) to Predict the Incidence of Xerostomia after Intensity-Modulated Radiotherapy for Head and Neck Cancer, PLoS ONE, vol.28, issue.2, p.89700, 2014.
DOI : 10.1371/journal.pone.0089700.t006

I. Beetz, C. Schilstra, A. Van-der-schaaf, E. Van-den-heuvel, P. Doornaert et al., NTCP models for patient-rated xerostomia and sticky saliva after treatment with intensity modulated radiotherapy for head and neck cancer: The role of dosimetric and clinical factors, Radiotherapy and Oncology, vol.105, issue.1, pp.101-107, 2012.
DOI : 10.1016/j.radonc.2012.03.004

G. Calais, E. Bardet, C. Sire, M. Alfonsi, J. Bourhis et al., Radiotherapy with concomitant weekly docetaxel for Stages III/IV oropharynx carcinoma. Results of the 98-02 GORTEC Phase II trial, International Journal of Radiation Oncology*Biology*Physics, vol.58, issue.1, pp.161-167, 2004.
DOI : 10.1016/S0360-3016(03)01370-1

T. Dijkema, C. Raaijmakers, T. Haken, R. Roesink, J. Braam et al., Parotid gland function after radiotherapy: the combined michigan and utrecht experience

K. Chao, D. Low, C. Perez, and J. Purdy, Intensity-modulated radiation therapy for head and neck cancer, Expert Review of Anticancer Therapy, vol.58, issue.3, pp.92-103, 2000.
DOI : 10.1016/S0360-3016(00)00476-4

K. Bohuslavizki, W. Brenner, S. Lassmann, S. Tinnemeyer, S. Kalina et al., Quantitative salivary gland scintigraphy--a recommended examination prior to and after radioiodine therapy], Nuklearmedizin, vol.36, issue.3, pp.103-112, 1997.

M. Voordeckers, A. Farrag, H. Everaert, K. Tournel, G. Storme et al., Parotid Gland Sparing With Helical Tomotherapy in Head-and-Neck Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.84, issue.2, pp.443-451, 2012.
DOI : 10.1016/j.ijrobp.2011.11.070

E. Chajon, C. Lafond, G. Louvel, J. Castelli, D. Williaume et al., Salivary gland-sparing other than parotid-sparing in definitive head-and-neck intensity-modulated radiotherapy does not seem to jeopardize local control, Radiation Oncology, vol.8, issue.1, p.132, 2013.
DOI : 10.1016/j.semradonc.2008.09.008

URL : https://hal.archives-ouvertes.fr/inserm-00833043

C. Ortholan, K. Benezery, and R. Bensadoun, [Normal tissue tolerance to external beam radiation therapy: salivary glands]. Cancer Radiother, pp.4-5290, 2010.

N. Nguyen, C. A. Betz, M. Almeida, F. Vos, P. Davis et al., Feasibility of Intensity-Modulated and Image-Guided Radiotherapy for Functional Organ Preservation in Locally Advanced Laryngeal Cancer, PLoS ONE, vol.7, issue.8, p.42729, 2012.
DOI : 10.1371/journal.pone.0042729.t004

N. Nguyen, P. Vos, V. Vinh-hung, M. Ceizyk, L. Smith-raymond et al., Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer, BMC Cancer, vol.9, issue.1, p.175, 2012.
DOI : 10.1177/153303461000900308

F. Stieler, D. Wolff, F. Lohr, V. Steil, Y. Abo-madyan et al., A fast radiotherapy paradigm for anal cancer with volumetric modulated arc therapy (VMAT), Radiation Oncology, vol.4, issue.1, p.48, 2009.
DOI : 10.1186/1748-717X-4-48

D. Wolff, F. Stieler, G. Welzel, F. Lorenz, Y. Abo-madyan et al., Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer, Radiotherapy and Oncology, vol.93, issue.2, pp.226-259, 2009.
DOI : 10.1016/j.radonc.2009.08.011

Y. Rong, G. Tang, J. Welsh, M. Mohiuddin, B. Paliwal et al., Helical Tomotherapy Versus Single-Arc Intensity-Modulated Arc Therapy: A Collaborative Dosimetric Comparison Between Two Institutions, International Journal of Radiation Oncology*Biology*Physics, vol.81, issue.1, pp.284-96, 2011.
DOI : 10.1016/j.ijrobp.2010.10.059

M. Davidson, S. Blake, D. Batchelar, P. Cheung, and K. Mah, Assessing the Role of Volumetric Modulated Arc Therapy (VMAT) Relative to IMRT and Helical Tomotherapy in the Management of Localized, Locally Advanced, and Post-Operative Prostate Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.80, issue.5, pp.1550-1558, 2011.
DOI : 10.1016/j.ijrobp.2010.10.024

M. Iori, G. Cattaneo, E. Cagni, C. Fiorino, G. Borasi et al., Dose-volume and biological-model based comparison between helical tomotherapy and (inverse-planned)

M. Rao, Y. W. Chen, F. Sheng, K. Ye, J. Mehta et al., Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: Plan quality, delivery efficiency and accuracy, Medical Physics, vol.26, issue.7, pp.1350-1359, 2010.
DOI : 10.1118/1.598615

S. Renard-oldrini, C. Brunaud, S. Huger, V. Marchesi, L. Tournier-rangeard et al., Dosimetric comparison between the intensity modulated radiotherapy with fixed field and Rapid Arc of cervix cancer]. Cancer Radiother, pp.209-223, 2012.

D. Pasquier, F. Cavillon, T. Lacornerie, C. Touzeau, E. Tresch et al., A dosimetric comparison of tomotherapy and volumetric modulated arc therapy in the treatment of highrisk prostate cancer with pelvic nodal radiation therapy, Int J Radiat Oncol Biol Phys, 2013.

A. Vaandering, J. Lee, R. L. Gregoire, and V. , Evaluation of MVCT protocols for brain and head and neck tumor patients treated with helical tomotherapy, Radiotherapy and Oncology, vol.93, issue.1, 2009.
DOI : 10.1016/j.radonc.2009.05.009

C. Lee, K. Langen, W. Lu, J. Haimerl, E. Schnarr et al., Assessment of Parotid Gland Dose Changes During Head and Neck Cancer Radiotherapy Using Daily Megavoltage Computed Tomography and Deformable Image Registration, International Journal of Radiation Oncology*Biology*Physics, vol.71, issue.5, pp.1563-71, 2008.
DOI : 10.1016/j.ijrobp.2008.04.013

J. Robar, A. Day, J. Clancey, R. Kelly, M. Yewondwossen et al., Spatial and Dosimetric Variability of Organs at Risk in Head-and-Neck Intensity-Modulated Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.68, issue.4
DOI : 10.1016/j.ijrobp.2007.01.030

K. Obinata, M. Nakamura, M. Carrozzo, I. Macleod, A. Carr et al., Changes in parotid gland morphology and function in patients treated with intensity-modulated radiotherapy for nasopharyngeal and oropharyngeal tumors, Oral Radiology, vol.11, issue.2, pp.135-176, 2014.
DOI : 10.1007/s003300000728

J. Castelli, A. Simon, G. Louvel, O. Henry, E. Chajon et al., Impact of head and neck cancer adaptive radiotherapy to spare the parotid glands and decrease the risk of xerostomia, Radiation Oncology, vol.10, issue.1, p.6, 2009.
DOI : 10.1016/j.oraloncology.2010.03.008

URL : https://hal.archives-ouvertes.fr/hal-01139625

S. Van-kranen, A. Mencarelli, S. Van-beek, C. Rasch, M. Van-herk et al., Adaptive radiotherapy with an average anatomy model: Evaluation and quantification of residual deformations in head and neck cancer patients, Radiotherapy and Oncology, vol.109, issue.3, pp.463-471, 2013.
DOI : 10.1016/j.radonc.2013.08.007

A. Brahme and A. Agren, Optimal Dose Distribution for Eradication of Heterogeneous Tumors, Acta Oncologica, vol.10, issue.5, pp.377-85, 1987.
DOI : 10.1016/0360-3016(84)90305-5

S. Webb and A. Nahum, A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density, Physics in Medicine and Biology, vol.38, issue.6, pp.653-66, 1993.
DOI : 10.1088/0031-9155/38/6/001

C. Ling, J. Humm, S. Larson, H. Amols, Z. Fuks et al., Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality, International Journal of Radiation Oncology*Biology*Physics, vol.47, issue.3, pp.551-60, 2000.
DOI : 10.1016/S0360-3016(00)00467-3

S. Bentzen and V. Gregoire, Molecular Imaging???Based Dose Painting: A Novel Paradigm for Radiation Therapy Prescription, Seminars in Radiation Oncology, vol.21, issue.2, pp.101-111, 2011.
DOI : 10.1016/j.semradonc.2010.10.001

M. Hatt, N. Boussion, C. Rest, C. Visvikis, D. Pradier et al., Metabolically active volumes automatic delineation methodologies in PET imaging: review and perspectives
URL : https://hal.archives-ouvertes.fr/inserm-00610621

I. Toma-dasu, J. Uhrdin, L. Antonovic, A. Dasu, S. Nuyts et al., Dose prescription and treatment planning based on FMISO-PET hypoxia, Acta Oncologica, vol.25, issue.2, pp.222-252, 2012.
DOI : 10.1200/JCO.2007.12.7878

W. Choi, S. Lee, S. Park, J. Ryu, S. Oh et al., Planning study for available dose of hypoxic tumor volume using fluorine-18-labeled fluoromisonidazole positron emission tomography for treatment of the head and neck cancer, Radiotherapy and Oncology, vol.97, issue.2, 2010.
DOI : 10.1016/j.radonc.2010.04.012

V. Gregoire, R. Jeraj, J. Lee, O. Sullivan, and B. , Radiotherapy for head and neck tumours in 2012 and beyond: conformal, tailored, and adaptive?, The Lancet Oncology, vol.13, issue.7, pp.292-300, 2012.
DOI : 10.1016/S1470-2045(12)70237-1

L. Cozzi, A. Fogliata, A. Lomax, and A. Bolsi, A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours, Radiotherapy and Oncology, vol.61, issue.3, pp.287-97, 2001.
DOI : 10.1016/S0167-8140(01)00403-0

J. Slater, J. Slater, and J. Archambeau, Carcinoma of the tonsillar region: Potential for use of proton beam therapy, International Journal of Radiation Oncology*Biology*Physics, vol.22, issue.2, pp.311-320, 1992.
DOI : 10.1016/0360-3016(92)90048-M

T. Van-de-water, H. Bijl, C. Schilstra, M. Pijls-johannesma, and J. Langendijk, The Potential Benefit of Radiotherapy with Protons in Head and Neck Cancer with Respect to Normal Tissue Sparing: A Systematic Review of Literature, The Oncologist, vol.16, issue.3, pp.366-77, 2011.
DOI : 10.1634/theoncologist.2010-0171

J. Johansson, E. Blomquist, A. Montelius, U. Isacsson, and B. Glimelius, Potential outcomes of modalities and techniques in radiotherapy for patients with hypopharyngeal carcinoma, Radiotherapy and Oncology, vol.72, issue.2, pp.129-167, 2004.
DOI : 10.1016/j.radonc.2004.03.018

M. Steneker, A. Lomax, and U. Schneider, Intensity modulated photon and proton therapy for the treatment of head and neck tumors, Radiotherapy and Oncology, vol.80, issue.2, pp.263-270, 2006.
DOI : 10.1016/j.radonc.2006.07.025

J. Muzik, M. Soukup, and M. Alber, Comparison of fixed-beam IMRT, helical tomotherapy, and IMPT for selected cases. Med Phys, pp.1580-92, 2008.

D. Thorwarth, M. Soukup, and M. Alber, Dose painting with IMPT, helical tomotherapy and IMXT: A dosimetric comparison, Radiotherapy and Oncology, vol.86, issue.1, pp.30-34, 2008.
DOI : 10.1016/j.radonc.2007.11.003

R. Flynn, S. Bowen, S. Bentzen, R. Mackie, T. Jeraj et al., Intensity-modulated x-ray (IMXT) versus proton (IMPT) therapy for theragnostic hypoxia-based dose painting, Physics in Medicine and Biology, vol.53, issue.15, pp.4153-67, 2008.
DOI : 10.1088/0031-9155/53/15/010

E. Lartigau, E. Tresch, J. Thariat, P. Graff, B. Coche-dequeant et al., Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer, Radiotherapy and Oncology, vol.109, issue.2, pp.281-286, 2013.
DOI : 10.1016/j.radonc.2013.08.012

. Annexe-n°2, Programme utilisé sur Matlab 2010 pour la réalisation des courbes de NTCP Annexe n°3 : Article sur l'étude d'ART PELVIS