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Dioxin exposure and breast cancer risk in the E3N cohort : multi-source exposures and timing of exposure

Abstract : Breast cancer (BC) is the first malignancy among women. Its incidence has doubled over the past 30 years. Environmental factors with endocrine disruptive properties, such as dioxins emitted from industrial combustion processes, are suspected to affect BC risk. Ingestion of contaminated food and inhalation are the major exposure routes in humans. Epidemiological evidence on the association between dioxin exposure and BC risk remains inconclusive due to methodological limitations. The aim of the thesis was to investigate the association between dioxin exposure and BC risk in the E3N prospective cohort, filling current methodological gaps.First, we assessed the association between estimated dietary dioxin exposure and BC risk among women from the E3N cohort. Second, we developed a geographic information system (GIS)-based metric to assess airborne dioxin exposure at the individual address level, including proximity to and technical characteristics of industrial sources, exposure duration and prevailing wind frequency. The metric was then applied to each E3N women’s addresses from 1990 to 2008, and airborne dioxin exposure was estimated for cases and matched controls from a cohort sub-population (the Rhône-Alpes region). Third, we estimated BC risk associated with cumulative airborne dioxin exposure. Overall, no statistically significant association was observed, except for a decrease in hormone-independent BC risk. The latter was significant for dietary dioxin exposure. For airborne exposure, we might have lacked statistical power and confirmation at the national level is required. The inverse association with ER-negative BC risk is consistent with experimental evidence
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Aurélie Danjou. Dioxin exposure and breast cancer risk in the E3N cohort : multi-source exposures and timing of exposure. Cancer. Université de Lyon, 2016. English. ⟨NNT : 2016LYSE1308⟩. ⟨tel-01662357⟩

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