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Vision-Oculomotricité et attention : Marqueurs cognitifs de dépistage chez des sujets atteints de schizophrénie

Abstract : Schizophrenia is a mental disorder that affects about 1% of the world's population and it represent one of the main causes of psychological disability. During several years, numerous studies have shown the presence of oculomotor as well as fine motor skills abnormalities in subjects belonging the spectrum of schizophrenia, highlighting the interest to deepen the search for biomarkers in this pathology.During my PhD’s thesis we conducted three studies to examine the oculomotor capability and the presence of Neurological Soft Signs (NSS) in patients with schizophrenia, full siblings of patients and subjects at Ultra High Risk for developing Psychosis (UHR) compared to health volunteers. For the first time we recorded memory guided saccades in UHR subjects in relation to the NSS (study 1). The results showed that subjects with schizophrenia, full siblings and UHR made more errors in this task when they were compared to control, particularly for UHR’s group with a higher score of NSS. The second study (study 2) allowed us to enlarged the investigations of visual fixation as well as of the pursuit eye movements. The results showed an instability of the fixation as well as a lack of saccadic control during pursuit especially for patients with a higher score of NSS. Finally, in the study 3, we used the machine learning method on the data to evaluate predictive values to better discriminate the four groups of subjects. This analysis allowed us to underline the importance of taking into account oculomotor parameters as well as the Neurological Soft Signs for the early detection of schizophrenia.
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Submitted on : Tuesday, December 12, 2017 - 12:55:53 AM
Last modification on : Tuesday, October 20, 2020 - 11:33:23 AM

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Simona Caldani. Vision-Oculomotricité et attention : Marqueurs cognitifs de dépistage chez des sujets atteints de schizophrénie. Neurosciences. Université Paris-Saclay, 2017. Français. ⟨NNT : 2017SACLS343⟩. ⟨tel-01661527⟩

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