R. Haddad and D. Shin, Recent Advances in Head and Neck Cancer, New England Journal of Medicine, vol.359, issue.11, pp.1143-54, 2008.
DOI : 10.1056/NEJMra0707975

J. Vermorken and P. Specenier, Optimal treatment for recurrent/metastatic head and neck cancer, Annals of Oncology, vol.21, issue.Supplement 7, pp.252-61, 2010.
DOI : 10.1093/annonc/mdq453

C. Leemans, B. Braakhuis, and R. Brakenhoff, The molecular biology of head and neck cancer, Nature Reviews Cancer, vol.83, issue.1, pp.9-22, 2011.
DOI : 10.1097/01.LAB.0000047489.26246.E1

N. Mockelmann, S. Laban, and K. Pantel, Circulating tumor cells in head and neck cancer: clinical impact in diagnosis and follow-up, European Archives of Oto-Rhino-Laryngology, vol.7, issue.7, pp.15-21, 2014.
DOI : 10.1371/journal.pone.0042048

G. Pantaleo and A. Harari, Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases, Nature Reviews Immunology, vol.41, issue.5, pp.417-440, 2006.
DOI : 10.4049/jimmunol.174.5.2900

F. Sallusto, J. Geginat, and A. Lanzavecchia, : Function, Generation, and Maintenance, Annual Review of Immunology, vol.22, issue.1, pp.745-63, 2004.
DOI : 10.1146/annurev.immunol.22.012703.104702

E. Lugli, M. Dominguez, and L. Gattinoni, Superior T memory stem cell persistence supports long-lived T cell memory, Journal of Clinical Investigation, vol.123, pp.594-603, 2013.
DOI : 10.1172/JCI66327DS1

R. Mortarini, A. Piris, and A. Maurichi, Lack of terminally differentiated tumorspecific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma, Cancer Res, vol.63, pp.2535-2580, 2003.

M. Inokuma, C. Dela-rosa, and C. Schmitt, Functional T Cell Responses to Tumor Antigens in Breast Cancer Patients Have a Distinct Phenotype and Cytokine Signature, The Journal of Immunology, vol.179, issue.4, pp.2627-2660, 2007.
DOI : 10.4049/jimmunol.179.4.2627

M. Cristofanilli, K. Broglio, and V. Guarneri, Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden, Clin Breast Cancer, vol.7, pp.471-480, 2007.

M. Larsen, D. Sauce, and L. Arnaud, Evaluating Cellular Polyfunctionality with a Novel Polyfunctionality Index, PLoS ONE, vol.7, issue.7, pp.42403-2012
DOI : 10.1371/journal.pone.0042403.s003

R. Mandal and T. Chan, Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy, Cancer Discovery, vol.6, issue.7, pp.703-716, 2016.
DOI : 10.1158/2159-8290.CD-16-0146

M. Yarchoan, B. Johnson, and E. Lutz, Targeting neoantigens to augment antitumour immunity, Nat Rev Cancer, p.2017

S. Patel and J. Shah, TNM Staging of Cancers of the Head and Neck: Striving for Uniformity Among Diversity, CA: A Cancer Journal for Clinicians, vol.55, issue.4, pp.242-58, 2005.
DOI : 10.3322/canjclin.55.4.242

O. Sullivan, B. Shah, and J. , New TNM staging criteria for head and neck tumors, Seminars in Surgical Oncology, vol.128, issue.1, pp.30-42, 2003.
DOI : 10.1002/ssu.10019

K. Manikantan, S. Sayed, and K. Syrigos, Challenges for the future modifications of the TNM staging system for head and neck cancer: Case for a new computational model?, Cancer Treatment Reviews, vol.35, issue.7, pp.639-683, 2009.
DOI : 10.1016/j.ctrv.2009.04.010

H. Streeck, Z. Brumme, and M. Anastario, Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1???Specific CD8+ T Cells, PLoS Medicine, vol.302, issue.5, p.100, 2008.
DOI : 10.1371/journal.pmed.0050100.st001

M. Precopio, M. Betts, and J. Parrino, T cell responses, The Journal of Experimental Medicine, vol.70, issue.6, pp.1405-1421, 2007.
DOI : 10.1016/S0145-305X(02)00039-3

A. Thakur, L. Pedersen, and G. Jungersen, Immune markers and correlates of protection for vaccine induced immune responses, Vaccine, vol.30, issue.33, pp.4907-4927, 2012.
DOI : 10.1016/j.vaccine.2012.05.049

S. Wilde, D. Sommermeyer, and M. Leisegang, Human Antitumor CD8+ T Cells Producing Th1 Polycytokines Show Superior Antigen Sensitivity and Tumor Recognition, The Journal of Immunology, vol.189, issue.2
DOI : 10.4049/jimmunol.1102165

J. Yuan, S. Gnjatic, and H. Li, CTLA-4 blockade enhances polyfunctional NY

Y. Mahnke, T. Brodie, and F. Sallusto, The who's who of T-cell differentiation: Human memory T-cell subsets, European Journal of Immunology, vol.340, issue.Suppl 2, pp.2797-809, 2013.
DOI : 10.1126/science.1235487

C. Riou, F. Treurnicht, and M. Abrahams, Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirusspecific CD8+ T cells Alexander-Miller MA: Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection, J Immunol REFERENCES BIBLIOGRAPHIQUES Cell Immunol, vol.189, issue.201, pp.3838-4758, 2000.

S. Artandi and R. Depinho, Telomeres and telomerase in cancer, Carcinogenesis, vol.31, issue.1, pp.9-18, 2010.
DOI : 10.1093/carcin/bgp268

A. Balar and J. Weber, PD-1 and PD-L1 antibodies in cancer: current status and future directions, Cancer Immunology, Immunotherapy, vol.15, issue.23, p.2017
DOI : 10.1158/1078-0432.CCR-09-1624

A. Balm, P. Hageman, and M. Van-doornewaard, Cytokeratin 18 expression in squamous cell carcinoma of the head and neck, European Archives of Oto-Rhino-Laryngology, vol.253, issue.4-5, pp.227-260, 1996.
DOI : 10.1007/BF00171132

M. Betts, M. Nason, and S. West, HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells, Blood, vol.107, issue.12, pp.4781-4790, 2006.
DOI : 10.1182/blood-2005-12-4818

A. Bozec, M. Ilie, and O. Dassonville, Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma, European Archives of Oto-Rhino-Laryngology, vol.9, issue.Suppl 3, pp.2745-2754, 2013.
DOI : 10.4103/0973-1482.16708

M. Buglione, S. Grisanti, and C. Almici, Circulating Tumour Cells in locally advanced head and neck cancer: Preliminary report about their possible role in predicting response to non-surgical treatment and survival, European Journal of Cancer, vol.48, issue.16, pp.3019-3045, 2012.
DOI : 10.1016/j.ejca.2012.05.007

A. Chaturvedi, E. Engels, and W. Anderson, Incidence Trends for Human Papillomavirus???Related and ???Unrelated Oral Squamous Cell Carcinomas in the United States, Journal of Clinical Oncology, vol.26, issue.4, pp.612-621, 2008.
DOI : 10.1200/JCO.2007.14.1713

S. Cohen, C. Punt, and N. Iannotti, Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer, Journal of Clinical Oncology, vol.26, issue.19, pp.3213-3234, 2008.
DOI : 10.1200/JCO.2007.15.8923

M. Cristofanilli, G. Budd, and M. Ellis, Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer, New England Journal of Medicine, vol.351, issue.8, pp.781-91, 2004.
DOI : 10.1056/NEJMoa040766

M. Cristofanilli, D. Hayes, and G. Budd, Circulating Tumor Cells: A Novel Prognostic Factor for Newly Diagnosed Metastatic Breast Cancer, Journal of Clinical Oncology, vol.23, issue.7, pp.1420-1450, 2005.
DOI : 10.1200/JCO.2005.08.140

D. Danila, G. Heller, and G. Gignac, Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer, Clinical Cancer Research, vol.13, issue.23, pp.7053-7061, 2007.
DOI : 10.1158/1078-0432.CCR-07-1506

Z. Ding, C. Liu, and Y. Cao, T cells, OncoImmunology, vol.5, issue.6, 2016.
DOI : 10.4049/jimmunol.1401894

E. Dotan, S. Cohen, and K. Alpaugh, Circulating Tumor Cells: Evolving Evidence and Future Challenges, The Oncologist, vol.14, issue.11, pp.1070-82, 2009.
DOI : 10.1634/theoncologist.2009-0094

G. Dunn, A. Bruce, and H. Ikeda, Cancer immunoediting: from immunosurveillance to tumor escape, Nature Immunology, vol.3, issue.11, pp.991-999, 2002.
DOI : 10.1038/ni1102-991

G. Dworacki, N. Meidenbauer, and I. Kuss, Decreased zeta chain expression and apoptosis in CD3+ peripheral blood T lymphocytes of patients with melanoma, Clin Cancer Res, vol.7, pp.947-957, 2001.

S. Farkona, E. Diamandis, and I. Blasutig, Cancer immunotherapy: the beginning of the end of cancer?, BMC Medicine, vol.72, issue.6230, p.73, 2016.
DOI : 10.1158/0008-5472.CAN-11-1620

W. Fridman, F. Pages, and C. Sautes-fridman, The immune contexture in human tumours: impact on clinical outcome, Nature Reviews Cancer, vol.29, issue.4, pp.298-306, 2012.
DOI : 10.1200/JCO.2010.30.6308

G. Galizia, M. Gemei, and M. Orditura, Postoperative Detection of Circulating Tumor Cells Predicts Tumor Recurrence in Colorectal Cancer Patients, Journal of Gastrointestinal Surgery, vol.33, issue.10 suppl, pp.1809-1827, 2013.
DOI : 10.1093/annonc/mdp463

M. Gillison, W. Koch, and R. Capone, Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers, Journal of the National Cancer Institute, vol.92, issue.9, pp.709-729, 2000.
DOI : 10.1093/jnci/92.9.709

A. Giordano, H. Gao, and S. Anfossi, Epithelial-Mesenchymal Transition and Stem Cell Markers in Patients with HER2-Positive Metastatic Breast Cancer, Molecular Cancer Therapeutics, vol.11, issue.11, pp.2526-2560, 2012.
DOI : 10.1158/1535-7163.MCT-12-0460

Y. Godet, E. Fabre, and M. Dosset, Analysis of Spontaneous Tumor-Specific CD4 T-cell Immunity in Lung Cancer Using Promiscuous HLA-DR Telomerase-Derived Epitopes: Potential Synergistic Effect with Chemotherapy Response, Clinical Cancer Research, vol.18, issue.10, pp.2943-53, 2012.
DOI : 10.1158/1078-0432.CCR-11-3185
URL : https://hal.archives-ouvertes.fr/inserm-00723050

O. Goodman, J. Fink, L. Symanowski, and J. , Circulating Tumor Cells in Patients with Castration-Resistant Prostate Cancer Baseline Values and Correlation with Prognostic Factors, Cancer Epidemiology Biomarkers & Prevention, vol.18, issue.6, pp.1904-1917, 2009.
DOI : 10.1158/1055-9965.EPI-08-1173

N. Goossens, S. Nakagawa, and X. Sun, Cancer biomarker discovery and validation, Transl Cancer Res, vol.4, pp.256-269, 2015.

T. Gorges, I. Tinhofer, and M. Drosch, Circulating tumour cells escape from EpCAMbased detection due to epithelial-to-mesenchymal transition, BMC Cancer, vol.12178, p.2012

J. Grandis, D. Falkner, and M. Melhem, Human leukocyte antigen class I allelic and haplotype loss in squamous cell carcinoma of the head and neck: clinical and immunogenetic consequences, Clin Cancer Res, vol.6, pp.2794-802, 2000.

S. Grisanti, C. Almici, and F. Consoli, Circulating Tumor Cells in Patients with Recurrent or Metastatic Head and Neck Carcinoma: Prognostic and Predictive Significance, PLoS ONE, vol.22, issue.8, 2014.
DOI : 10.1371/journal.pone.0103918.s003

A. Grobe, M. Blessmann, and H. Hanken, Prognostic Relevance of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow of Patients with Squamous Cell Carcinoma of the Oral Cavity, Clinical Cancer Research, vol.20, issue.2, pp.425-458, 2014.
DOI : 10.1158/1078-0432.CCR-13-1101

I. Gruber, N. Landenberger, and A. Staebler, Relationship between circulating tumor cells and peripheral T-cells in patients with primary breast cancer, Anticancer Res, vol.33, pp.2233-2241, 2013.

T. Hama, Y. Yuza, and T. Suda, Functional mutation analysis of EGFR family genes and corresponding lymph node metastases in head and neck squamous cell carcinoma, Clinical & Experimental Metastasis, vol.25, issue.16
DOI : 10.1200/JCO.2006.07.6547

L. Hammarstedt, D. Lindquist, and H. Dahlstrand, Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer, International Journal of Cancer, vol.104, issue.11, pp.2620-2623, 2006.
DOI : 10.1093/jnci/djg107

D. Hanahan and R. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-74, 2011.
DOI : 10.1016/j.cell.2011.02.013

C. Harley, Telomerase and cancer therapeutics, Nature Reviews Cancer, vol.22, issue.3, pp.167-79, 2008.
DOI : 10.1128/MCB.19.1.567

S. He, P. Li, and X. Chen, Fluid biopsy for circulating tumor cells in an occult ovarian cancer patient exhibiting bilateral supraclavicular lymph node metastases: A case report

M. Hellerstein, M. Hanley, and D. Cesar, Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans, Nature Medicine, vol.5, issue.1, pp.83-92, 1999.
DOI : 10.1038/4772

K. Hiraiwa, H. Takeuchi, and H. Hasegawa, Clinical Significance of Circulating Tumor Cells in Blood from Patients with Gastrointestinal Cancers, Annals of Surgical Oncology, vol.13, issue.11, pp.3092-100, 2008.
DOI : 10.1089/scd.1.1994.3.165

T. Hoffmann, G. Dworacki, and T. Tsukihiro, Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance, Clin Cancer Res, vol.8, pp.2553-62, 2002.

T. Hoffmann, K. Nakano, and E. Elder, Generation of T Cells Specific for the Wild-Type Sequence p53264-272 Peptide in Cancer Patients: Implications for Immunoselection of Epitope Loss Variants, The Journal of Immunology, vol.165, issue.10, pp.5938-5982, 2000.
DOI : 10.4049/jimmunol.165.10.5938

C. Hudis, W. Barlow, and J. Costantino, Proposal for Standardized Definitions for Efficacy End Points in Adjuvant Breast Cancer Trials: The STEEP System, Journal of Clinical Oncology, vol.25, issue.15, pp.2127-2159, 2007.
DOI : 10.1200/JCO.2006.10.3523

T. Ikawa, M. Eura, and T. Fukiage, Adoptive immunotherapy by intra-arterial infusion of ATLAK or Allo-TLAK cells in patients with head and neck cancer], Gan To Kagaku Ryoho, vol.16, pp.1438-1485, 1989.

H. Ikeda, L. Old, and R. Schreiber, The roles of IFN?? in protection against tumor development and cancer immunoediting, Cytokine & Growth Factor Reviews, vol.13, issue.2, pp.95-109, 2002.
DOI : 10.1016/S1359-6101(01)00038-7

T. Ishikawa, T. Ikawa, and M. Eura, Adoptive Immunotherapy for Head and Neck Cancer with Killer Cells Induced by Stimulation with Autologous or Allogeneic Tumour Cells and Recombinant Interleukin-2, Acta Oto-Laryngologica, vol.116, issue.5-6, pp.346-51, 1989.
DOI : 10.1007/BF00200020

K. Jatana, P. Balasubramanian, and J. Lang, Significance of Circulating Tumor Cells in Patients With Squamous Cell Carcinoma of the Head and Neck, Archives of Otolaryngology???Head & Neck Surgery, vol.136, issue.12, pp.1274-1283, 2010.
DOI : 10.1001/archoto.2010.223

N. Kay, T. Leong, and N. Bone, Blood levels of immune cells predict survival in myeloma patients: results of an Eastern Cooperative Oncology Group phase 3 trial for newly diagnosed multiple myeloma patients, Blood, vol.98, issue.1, pp.23-31, 2001.
DOI : 10.1182/blood.V98.1.23

R. Kennedy and E. Celis, T cells in anti-tumor immune responses, Immunological Reviews, vol.161, issue.1, pp.129-173, 2008.
DOI : 10.1038/nbt1215

J. Kim, E. Wieckowski, and D. Taylor, Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes, Clin Cancer Res, vol.11, pp.1010-1030, 2005.

R. Konigsberg, E. Obermayr, and G. Bises, Detection of EpCAM positive and negative circulating tumor cells in metastatic breast cancer patients, Acta Oncologica, vol.185, issue.5, pp.700-710, 2011.
DOI : 10.1186/bcr2333

I. Kuss, B. Hathaway, and R. Ferris, Imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease, Adv Otorhinolaryngol, vol.62, pp.161-72, 2005.

J. Lang, L. Gao, and Y. Guo, Comprehensive treatment of squamous cell cancer of head and neck: Chinese expert consensus 2013, Future Oncology, vol.18, issue.9, pp.1635-1683, 2014.
DOI : 10.1007/s00405-012-2209-y

W. Li, C. Thompson, O. Brien, and C. , Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil, International Journal of Cancer, vol.13, issue.4, pp.553-561, 2003.
DOI : 10.1002/ijc.11261

R. Mandal and T. Chan, Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy, Cancer Discovery, vol.6, issue.7, pp.703-716, 2016.
DOI : 10.1158/2159-8290.CD-16-0146

A. Marimuthu, S. Chavan, and G. Sathe, Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1834, issue.11
DOI : 10.1016/j.bbapap.2013.04.029

P. Martinez and M. Blasco, Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins, Nature Reviews Cancer, vol.279, issue.3, pp.161-76, 2011.
DOI : 10.1074/jbc.M409047200

S. Marur and A. Forastiere, Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment, Mayo Clinic Proceedings, vol.91, issue.3, pp.386-96, 2016.
DOI : 10.1016/j.mayocp.2015.12.017

J. Matsuzaki, T. Tsuji, and I. Luescher, Nonclassical Antigen-Processing Pathways Are Required for MHC Class II-Restricted Direct Tumor Recognition by NY-ESO-1-Specific CD4+ T Cells, Cancer Immunology Research, vol.2, issue.4, pp.341-50, 2014.
DOI : 10.1158/2326-6066.CIR-13-0138

M. Mego, S. Mani, and M. Cristofanilli, Molecular mechanisms of metastasis in breast cancer???clinical applications, Nature Reviews Clinical Oncology, vol.14, issue.12, pp.693-701, 2010.
DOI : 10.1158/0008-5472.SABCS-09-3011

M. Mego, D. Giorgi, U. Dawood, and S. , Characterization of metastatic breast cancer patients with nondetectable circulating tumor cells, International Journal of Cancer, vol.20, issue.Suppl 1, pp.417-440, 2011.
DOI : 10.1093/annonc/mdp207

M. Mego, H. Gao, and E. Cohen, Circulating Tumor Cells (CTC) Are Associated with Defects in Adaptive Immunity in Patients with Inflammatory Breast Cancer, Journal of Cancer, vol.7, issue.9, pp.1095-104, 2016.
DOI : 10.7150/jca.13098

B. Mlecnik, M. Tosolini, and A. Kirilovsky, Histopathologic-Based Prognostic Factors of Colorectal Cancers Are Associated With the State of the Local Immune Reaction, Journal of Clinical Oncology, vol.29, issue.6, pp.610-618, 2011.
DOI : 10.1200/JCO.2010.30.5425

J. Moreno, O. Hara, S. Gross, and S. , Changes in circulating carcinoma cells in patients with metastatic prostate cancer correlate with disease status, Urology, vol.58, issue.3, pp.386-92, 2001.
DOI : 10.1016/S0090-4295(01)01191-8

B. Mostert, J. Kraan, and A. Sieuwerts, CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes, Cancer Letters, vol.319, issue.1, pp.49-55, 2012.
DOI : 10.1016/j.canlet.2011.12.031

S. Mueller and R. Ahmed, High antigen levels are the cause of T cell exhaustion during chronic viral infection, Proceedings of the National Academy of Sciences, vol.8, issue.2, pp.8623-8631, 2009.
DOI : 10.1016/S1074-7613(00)80470-7

W. Murphy, T. Back, and K. Conlon, Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts., Journal of Clinical Investigation, vol.92, issue.4, pp.1918-1942, 1993.
DOI : 10.1172/JCI116785

E. Murta, J. De-andrade, and R. Falcao, Lymphocyte subpopulations in patients with advanced breast cancer submitted to neoadjuvant chemotherapy, Tumori, vol.86, pp.403-410, 2000.

K. Nakazaki, Y. Kato, and T. Taguchi, Heterozygous mutationA) at nt 2607 of the EGFR gene is closely associated with increases in EGFR copy number and mRNA half life, but impaired EGFR protein synthesis in squamous cell carcinomas of the head and neck -implication for gefitinib efficacy, Oncol Lett, vol.1, pp.1017-1020, 2010.

R. Neese, S. Siler, and D. Cesar, Advances in the Stable Isotope???Mass Spectrometric Measurement of DNA Synthesis and Cell Proliferation, Analytical Biochemistry, vol.298, issue.2, pp.189-95, 2001.
DOI : 10.1006/abio.2001.5375

B. Negin and S. Cohen, Circulating Tumor Cells in Colorectal Cancer: Past, Present, and Future Challenges, Current Treatment Options in Oncology, vol.25, issue.13, pp.1-13, 2010.
DOI : 10.1007/s11864-010-0115-3

A. Nichols, L. Lowes, and C. Szeto, Detection of circulating tumor cells in advanced head and neck cancer using the cellsearch system, Head & Neck, vol.107, issue.Suppl 9, pp.1440-1444, 2012.
DOI : 10.1111/j.1464-410X.2010.09562.x

A. Offermann, Z. Shaikhibrahim, and S. Perner, MED15: a potential biomarker for head and neck squamous cell carcinoma?, Biomarkers in Medicine, vol.9, issue.1, pp.939-980, 2015.
DOI : 10.1016/j.ajpath.2014.12.010

O. Sullivan, B. Shah, and J. , New TNM staging criteria for head and neck tumors, Seminars in Surgical Oncology, vol.128, issue.1, pp.30-42, 2003.
DOI : 10.1002/ssu.10019

C. Pecot, F. Bischoff, and J. Mayer, A Novel Platform for Detection of CK+ and CK- CTCs, Cancer Discovery, vol.1, issue.7, pp.580-586, 2011.
DOI : 10.1158/2159-8290.CD-11-0215

F. Porichis, M. Hart, and J. Zupkosky, Differential Impact of PD-1 and/or Interleukin-10 Blockade on HIV-1-Specific CD4 T Cell and Antigen-Presenting Cell Functions, Journal of Virology, vol.88, issue.5, pp.2508-2526, 2014.
DOI : 10.1128/JVI.02034-13

M. Precopio, M. Betts, and J. Parrino, T cell responses, The Journal of Experimental Medicine, vol.70, issue.6, pp.1405-1421, 2007.
DOI : 10.1016/S0145-305X(02)00039-3

C. Raimondi, A. Gradilone, and G. Naso, Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients, Breast Cancer Research and Treatment, vol.69, issue.10, pp.449-55, 2011.
DOI : 10.1158/0008-5472.CAN-09-0654

T. Reichert, C. Scheuer, and R. Day, The number of intratumoral dendritic cells and ?-chain expression in T cells as prognostic and survival biomarkers in patients with oral carcinoma, Cancer, vol.13, issue.11, pp.2136-2183, 2001.
DOI : 10.1007/978-1-4757-9966-8_7

T. Reichert, L. Strauss, and E. Wagner, Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma, Clin Cancer Res, vol.8, pp.3137-3182, 2002.

S. Riethdorf, H. Fritsche, and V. Muller, Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System, Clinical Cancer Research, vol.13, issue.3, pp.920-928, 2007.
DOI : 10.1158/1078-0432.CCR-06-1695

C. Riou, F. Treurnicht, and M. Abrahams, Increased Memory Differentiation Is Associated with Decreased Polyfunctionality for HIV but Not for Cytomegalovirus-Specific CD8+ T Cells, The Journal of Immunology, vol.189, issue.8, pp.3838-3885, 2012.
DOI : 10.4049/jimmunol.1201488

S. Rosenberg, Progress in human tumour immunology and immunotherapy, Nature, vol.411, issue.6835, pp.380-384, 2001.
DOI : 10.1038/35077246

R. Grandis, J. Melhem, M. Gooding, and W. , Levels of TGF-?? and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival, JNCI: Journal of the National Cancer Institute, vol.90, issue.11, pp.824-856, 1998.
DOI : 10.1093/jnci/90.11.824

N. Sah, Z. Khan, and G. Khan, Structural, functional and therapeutic biology of survivin, Cancer Letters, vol.244, issue.2, pp.164-71, 2006.
DOI : 10.1016/j.canlet.2006.03.007

T. Saito, I. Kuss, and G. Dworacki, Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer, Clin Cancer Res, vol.5, pp.1263-73, 1999.

K. Schumacher, W. Haensch, and C. Roefzaad, Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas, Cancer Res, vol.61, pp.3932-3938, 2001.

R. Seder, P. Darrah, and M. Roederer, T-cell quality in memory and protection: implications for vaccine design, Nature Reviews Immunology, vol.27, issue.4, pp.247-58, 2008.
DOI : 10.4049/jimmunol.173.9.5372

F. Sipos and O. Galamb, Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon, World Journal of Gastroenterology, vol.18, issue.7, pp.601-609, 2012.
DOI : 10.3748/wjg.v18.i7.601

Y. Sun, X. Yang, and J. Zhou, Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance, Journal of Cancer Research and Clinical Oncology, vol.88, issue.7, pp.1151-73, 2011.
DOI : 10.1007/s00109-010-0617-2

R. Takes, B. D. Jong, R. Alles, and M. , Markers for Nodal Metastasis in Head and Neck Squamous Cell Cancer, Archives of Otolaryngology???Head & Neck Surgery, vol.128, issue.5, pp.512-520, 2002.
DOI : 10.1001/archotol.128.5.512

I. Tinhofer, R. Konschak, and C. Stromberger, Detection of circulating tumor cells for prediction of recurrence after adjuvant chemoradiation in locally advanced squamous cell carcinoma of the head and neck, Annals of Oncology, vol.25, issue.10, pp.2042-2049, 2014.
DOI : 10.1093/annonc/mdu271

L. Torre, F. Bray, and R. Siegel, Global cancer statistics, 2012, Global cancer statistics, pp.87-108, 2012.
DOI : 10.1038/nrc1948

N. Tran, B. Rose, O. Brien, and C. , Role of human papillomavirus in the etiology of head and neck cancer, Head & Neck, vol.4, issue.1, pp.64-70, 2007.
DOI : 10.3201/eid1011.040222

Q. Tu, X. Wu, L. Rhun, and E. , CellSearch?? technology applied to the detection and quantification of tumor cells in CSF of patients with lung cancer leptomeningeal metastasis, Lung Cancer, vol.90, issue.2, pp.352-359, 2015.
DOI : 10.1016/j.lungcan.2015.09.008

G. Van-dalum, G. Van-der-stam, and A. Tibbe, Circulating tumor cells before and during follow-up after breast cancer surgery, International Journal of Oncology, vol.46, issue.1, pp.407-420, 2015.
DOI : 10.3892/ijo.2014.2694

J. Vermorken and P. Specenier, Optimal treatment for recurrent/metastatic head and neck cancer, Annals of Oncology, vol.21, issue.Supplement 7, pp.252-61, 2010.
DOI : 10.1093/annonc/mdq453

S. Warnakulasuriya, Global epidemiology of oral and oropharyngeal cancer, Oral Oncology, vol.45, issue.4-5, pp.309-325, 2009.
DOI : 10.1016/j.oraloncology.2008.06.002

P. Went, A. Lugli, and S. Meier, Frequent EpCam protein expression in human carcinomas, Human Pathology, vol.35, issue.1, pp.122-130, 2004.
DOI : 10.1016/j.humpath.2003.08.026

X. Wu, R. Mastronicola, and Q. Tu, A rare case of extremely high counts of circulating tumor cells detected in a patient with an oral squamous cell carcinoma, BMC Cancer, vol.17, issue.10, p.552, 2016.
DOI : 10.1007/s11605-013-2258-6
URL : https://hal.archives-ouvertes.fr/hal-01415410

X. Wu, Q. Tu, and G. Faure, Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis, Scientific Reports, vol.45, issue.1, 2016.
DOI : 10.1515/CCLM.2007.301
URL : https://hal.archives-ouvertes.fr/hal-01320589

Y. Xie, A. Akpinarli, and C. Maris, T cells differentiated in vivo eradicate established melanoma, The Journal of Experimental Medicine, vol.146, issue.3, pp.651-67, 2010.
DOI : 10.1038/nm1312

T. Yamashita, H. Shimada, and S. Tanaka, Serum midkine as a biomarker for malignancy, prognosis, and chemosensitivity in head and neck squamous cell carcinoma, Cancer Medicine, vol.132, issue.1 Pt 1, pp.415-440, 2016.
DOI : 10.1093/oxfordjournals.jbchem.a003231

M. Yarchoan, B. Johnson, and E. Lutz, Targeting neoantigens to augment antitumour immunity, Nat Rev Cancer, p.2017

M. Young, Protective mechanisms of head and neck squamous cell carcinomas from immune assault, Head & Neck, vol.174, issue.5, pp.462-70, 2006.
DOI : 10.4049/jimmunol.174.7.3992

M. Yu, A. Bardia, and B. Wittner, Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition, Science, vol.2, issue.5, pp.580-584, 2013.
DOI : 10.1002/emmm.201000070

J. Yuan, S. Gnjatic, and H. Li, CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit, Proceedings of the National Academy of Sciences, vol.92, issue.6, pp.20410-20415, 2008.
DOI : 10.1002/ijc.1282

M. Zanetti, Tapping CD4 T Cells for Cancer Immunotherapy: The Choice of Personalized Genomics, The Journal of Immunology, vol.194, issue.5, pp.2049-56, 2015.
DOI : 10.4049/jimmunol.1402669

L. Zhang, S. Riethdorf, and G. Wu, Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer, Clinical Cancer Research, vol.18, issue.20, pp.5701-5711, 2012.
DOI : 10.1158/1078-0432.CCR-12-1587

B. Zier and J. Pimlott, Mechanical plaque control: are concepts changing?, Probe, vol.21, pp.123-132, 1987.