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Stimulations du cervelet pour le traitement des dyskinésies induites par la lévodopa dans la maladie de Parkinson

Abstract : Levodopa is currently the gold standard treatment for Parkinson’s disease patients and artificially restores dopamine levels. However, it induces debilitating abnormal involuntary movements, or dyskinesia. During my thesis, I assessed the involvement of the cerebellar crus II region Purkinje cells, via the cerebello-thalamo-cortico-striatal and cerebello-thalamo-striatal pathways, in the onset and the treatment of levodopa induced oro-lingual abnormal involuntary movements, in a mouse model of Parkinson’s disease. My results suggest that the chronic and specific stimulation of Purkinje cells, using optogenetics, seems able to correct and prevent the dyskinetic phenotype, together with modulations of the activity of the parafascicular intralaminar thalamic nucleus, primary oral motor cortex and dorsal striatum, thus arguing for the involvement of the cerebello-thalamo-cortico-striatal and the cerebello-thalamo-striatal pathways in the corrective and preventive treatment for levodopa induced dyskinesia in Parkinson’s disease.
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Submitted on : Saturday, December 9, 2017 - 1:09:29 AM
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Adèle Bousquet Combes. Stimulations du cervelet pour le traitement des dyskinésies induites par la lévodopa dans la maladie de Parkinson. Neurosciences [q-bio.NC]. Université Pierre et Marie Curie - Paris VI, 2017. Français. ⟨NNT : 2017PA066134⟩. ⟨tel-01659925⟩

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