Skip to Main content Skip to Navigation
Theses

Méthodologie statistique pour la prédiction du risque et la construction de score pronostique en transplantation rénale et en oncologie : une pierre angulaire de la médecine de précision

Abstract : Prognosis is historically a basic concept of medicine. Hippocrates already considered the prognosis of disease as the study of the past circumstances, the establishment of the present state of health and finally the prediction of future events. He presented the prognosis as the ability to interpret these elements and to adapt the prognosis regarding their relative values. Currently, the prognostic research is still based on the examination of the relationship between a well-established health condition at the time of the investigation and the occurrence of an event. The increase in life expectancy implies that more and more people are living with one or more diseases or with problems that can impair their health status. In this context, the study of the prognosis has never been more important. However, in comparison with the field of randomized clinical trials in which the CONSORT statement recommendations are implemented for more than 20 years in order to guarantee quality research, the prognostic research only begins to develop similar initiatives. Indeed, in 2015 the TRIPOD statement recommendations were provided and in 2013 a working group called PROGRESS was constituted in the United Kingdom and its members made the observation that prognostic researches are developed with considerable heterogeneity in the methodology used and unfortunately do not always meet the quality standards required to support their conclusions and their reproducibility (...)
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-01659921
Contributor : Abes Star :  Contact
Submitted on : Saturday, December 9, 2017 - 1:06:00 AM
Last modification on : Wednesday, October 14, 2020 - 4:00:04 AM
Long-term archiving on: : Saturday, March 10, 2018 - 12:38:12 PM

File

these_A_VERNEREY_Dewi_2016.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01659921, version 1

Collections

Citation

Dewi Vernerey. Méthodologie statistique pour la prédiction du risque et la construction de score pronostique en transplantation rénale et en oncologie : une pierre angulaire de la médecine de précision. Cancer. Université de Franche-Comté, 2016. Français. ⟨NNT : 2016BESA3004⟩. ⟨tel-01659921⟩

Share

Metrics

Record views

767

Files downloads

339