Contributions in Mathematical Oncology: When Theory Meets Reality

Sébastien Benzekry 1, 2
2 MONC - Modélisation Mathématique pour l'Oncologie
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, Institut Bergonié - CRLCC Bordeaux
Abstract : Accumulation of new biological and clinical data thanks to the development and generalization of novel measurement techniques (especially in imaging or molecular biology) is currently driving oncology towards a quantitative science. Meanwhile, mathematical models developed by theoreticians have often remained confined to qualitative conclusions and rarely been confronted to the observations. The work presented here aims to bridge this gap. Motivated by concrete biological or clinical questions, I have conducted combined experimental and theoretical studies with two main objectives: 1) better understand and 2) better predict. The contributions belong to three axis of research: tumor growth, metastasis and scheduling of anti-cancer treatments. The mathematical tools are mostly ordinary differential equations or physiologically structured partial differential equations. Statistical tools were also largely employed to fit the models to the data and test the hypotheses, with a major focus on nonlinear mixed-effects models. Together, these contributions represent a step forward towards the development of quantitative methods in cancer biology. They also set the basis for computational tools of clinical value to help defining the design of clinical trials (at the population level) but also to better assess the diagnosis and prognosis of a cancer disease in a personalized way, in order to individually tailor the therapeutic intervention.
Complete list of metadatas

Cited literature [283 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-01658070
Contributor : Sebastien Benzekry <>
Submitted on : Thursday, December 7, 2017 - 12:01:57 PM
Last modification on : Thursday, May 9, 2019 - 1:40:17 PM

File

HDR_benzekry.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01658070, version 1

Citation

Sébastien Benzekry. Contributions in Mathematical Oncology: When Theory Meets Reality. Mathematics [math]. Université de Bordeaux, 2017. ⟨tel-01658070⟩

Share

Metrics

Record views

436

Files downloads

959