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Impact de la prise chronique de paracétamol sur le muscle et le besoin en cystéine chez le rat âgé. : Nutrition Humaine

Abstract : The age-related muscle mass and functionality loss, named sarcopenia is a physiological processknown as a direct cause of frailty. Both geriatrics syndromes have been correlated to various factorsas nutritional status and medication. However, the interactions between medication and muscle havenot being deeply investigated, especially in elderly. Using this model, we have highlighted a 12% loss of muscle mass in old rat under repeatedparacetamol cures. This loss was associated with paracetamol-induced sulfur amino acid disturbancesleading to altered glutathione (GSH a Cys containing tripeptide) status and circulating Cys. All together, these results emphasize that muscle mass loss induced by repeated cures withparacetamol in old rats arise from the increased protein and more specifically Cys requirements. Therelevance of these results for older persons needs to be further evaluated before considering whetherit it could be of interest to develop nutritional recommendations aimed to optimized protein intake orCys supplementation during cures with paracetamol. That could further increase the benefit/risk ratioof paracetamol which is widely prescribed for pain relief, especially in older people.
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Carole Mast. Impact de la prise chronique de paracétamol sur le muscle et le besoin en cystéine chez le rat âgé. : Nutrition Humaine. Médecine humaine et pathologie. Université d'Auvergne - Clermont-Ferrand I, 2014. Français. ⟨NNT : 2014CLF1MM17⟩. ⟨tel-01657408⟩

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