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Etude de la biomécanique cellulaire à l'aide de MEMS piézoélectriques organiques

Abstract : This PhD thesis is the result of an assessment : the use of organic materials in MEMSis in a constant increase. Organic materials are attractive because of their low-cost fabrication processand their properties that are different from the inorganic ones. From a biological point of view, theirphysical and chemical properties are closer to the properties of extracellular environment. MEMS arevery versatile systems that are able to measure a lot of physical quantities. Therefore, it is not surprisingto use them in biology, and combining MEMS with organic materials is really promising tostudy biological cells behavior. The objective of this work is to fabricate and use piezoelectric organicMEMS resonators to study cell biomechanics and adhesion. In fact, the study of cell biomechanicsgives information on a lot of cellular processes, like the cellular adhesion, as well as on their well-being.Firstly, the resonators fabrication process has been developed and optimized in order to maximize thepiezoelectric actuation. Secondly, an electronic actuation and measurement system has been realized,including an electronic card and a watertight enclosure. The influence of the temperature, mass densityand viscosity of the environment on the dynamic response of the resonators has also been evaluated.Finally, real time measurements of the adhesion of mesenchymal stem cells have been carried out usingthe resonators. The resonators have also been used to study the influence of the position of a mass onthe resonators, to determine the rigidity of a deposited material as well as the viscosity of liquid media.
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Submitted on : Monday, December 4, 2017 - 10:45:14 AM
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Pierre-Henri Ducrot. Etude de la biomécanique cellulaire à l'aide de MEMS piézoélectriques organiques. Autre. Université de Bordeaux, 2017. Français. ⟨NNT : 2017BORD0671⟩. ⟨tel-01654591⟩

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