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Analyse du comportement électrochimique de matériaux d'électrodes biocompatibles, utilisables comme électrodes dans un dispositif de diagnostic médical non invasif

Abstract : A non-invasive device based on measurements of electrochemical skin conductance can detect small fiber neuropathy, a sweat gland dysfunction implicated in several diseases. In this context, the SudoscanTM technology developed by Impeto Medical provides early diagnosis, rapid and noninvasive analysis. This technology is based on measurements of skin current density via the imposition of low amplitude voltages (4 to 1.5V) between electrodes applied to the skin and measuring the low current generated. These electrodes are sensitive to the composition of the sweat produced by the eccrine glands when stimulated. The results obtained in vivo provide a characteristic response on the anode, which determines the type of disease and its progress. To better understand the phenomena involved at electrodes and to optimize the sensitivity of in vivo measurements, manipulations were performed in vitro with solutions mimicking the composition of the sweat. To simulate the resistance of the body and to reduce the current densities obtained in vitro, the viscosity of the electrolyte has been increased. This electrolyte has achieved in vitro current densities similar to those obtained in vivo. The second objective of this study is to analyze the electrochemical behavior of different biocompatible stainless steels and their corrosion resistance in a physiological medium at neutral pH. We specifically interested in the influence of the chloride ion concentration on the corrosion, in the range of sweat’s. The objective is to enable a better understanding of the phenomena involved and analyze the sensitivity of materials to chloride ions, to determine the most promising material for technology.
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Submitted on : Wednesday, November 29, 2017 - 1:02:26 AM
Last modification on : Sunday, October 25, 2020 - 1:48:45 PM

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  • HAL Id : tel-01651345, version 1

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Amandine Calmet. Analyse du comportement électrochimique de matériaux d'électrodes biocompatibles, utilisables comme électrodes dans un dispositif de diagnostic médical non invasif. Génie chimique. Université Pierre et Marie Curie - Paris VI, 2015. Français. ⟨NNT : 2015PA066694⟩. ⟨tel-01651345⟩

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