La supplémentation périnatale en fibres prébiotiques (fructo-oligosaccharides à courte chaîne, scFOS) modifie le microbiote intestinal et programme le phénotype métabolique et immunitaire du porc, pris comme modèle de l’Homme

Abstract : Perinatal scFOS supplementation modifies metabolic response to an unbalanced diet in adults by stimulating intestinal endocrine function and pancreas sensitivity to glucose, by reducing risks of inflammation, and in fine by changing metabolic homeostasis in association with modifications of microbiota.In summary, prebiotic consumption during perinatal life programs the immune and metabolic phenotype of adults through persistent modulations of intestinal microbiota. The integrated approach of data enables us to identify molecular actors involved in the differential adaptation of individuals to an unbalanced diet according to their perinatal nutrition.
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Cindy Le Bourgot. La supplémentation périnatale en fibres prébiotiques (fructo-oligosaccharides à courte chaîne, scFOS) modifie le microbiote intestinal et programme le phénotype métabolique et immunitaire du porc, pris comme modèle de l’Homme. Alimentation et Nutrition. Agrocampus Ouest, 2016. Français. ⟨NNT : 2016NSARB285⟩. ⟨tel-01649877⟩

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