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Diversité génétique et sensibilité aux antifongiques d’isolats cliniques et environnementaux de Cryptococcus à Abidjan, Côte d’Ivoire.

Abstract : Cryptococcal meningitis (CM) is the second opportunistic infection in HIV infected patients. It is the fourth cause of death due to infectious diseases in Africa with an annual mortality of 600,000. The yeasts responsible belong to the C. neoformans / Cryptococcus gattii species complex. Our study describes epidemiology and resistance to antifungal of environmental and clinical strains of Cryptococcus in Ivory Coast. The isolates are from an active list of 1,750 patients VIH positive and 667 samples taken in the living environment of patients. We demonstrate a high genotypic diversity within our cohort and the presence of several species of Cryptococcus in one sample from the same patient as well as in samples from patients follow up, which had never been shown in West Africa. We found that the recurrent cryptococcosis is caused by multiple infections by different strains over time. Our results describe also, for the first time, the isolation of Cryptococcus from pigeon droppings from Abidjan. And we notice that, as the genotypes of environmental and clinical isolates are very different, that excludes contamination of patients by pigeon droppings. Finally, most of the isolates were susceptible to reference antifungal but a patient might be contaminated by isolates with different susceptibility.
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https://tel.archives-ouvertes.fr/tel-01628628
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Kondo Kassi. Diversité génétique et sensibilité aux antifongiques d’isolats cliniques et environnementaux de Cryptococcus à Abidjan, Côte d’Ivoire.. Maladies infectieuses. Université Montpellier; Université Félix Houphouët-Boigny (Abidjan, Côte d'Ivoire), 2016. Français. ⟨NNT : 2016MONT3521⟩. ⟨tel-01628628⟩

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