D. Dowling and L. Simmons, Reactive oxygen species as universal constraints in life-history evolution, Proceedings of the Royal Society B: Biological Sciences, vol.160, issue.1, pp.1737-1782, 2009.
DOI : 10.1146/annurev.ecolsys.32.081501.114006
URL : http://rspb.royalsocietypublishing.org/content/royprsb/276/1663/1737.full.pdf

R. Scherz-shouval and Z. Elazar, Regulation of autophagy by ROS: physiology and pathology, Trends in Biochemical Sciences, vol.36, issue.1, pp.30-38, 2011.
DOI : 10.1016/j.tibs.2010.07.007

W. Dröge, Free Radicals in the Physiological Control of Cell Function, Physiological Reviews, vol.82, issue.1, pp.47-95, 2002.
DOI : 10.1152/physrev.00018.2001

P. Pacher, J. Beckman, and L. Liaudet, Nitric Oxide and Peroxynitrite in Health and Disease, Physiological Reviews, vol.87, issue.1, pp.315-424, 2007.
DOI : 10.1152/physrev.00029.2006

M. Valko, M. Izakovic, and M. Mazur, Role of oxygen radicals in DNA damage and cancer incidence, Molecular and Cellular Biochemistry, vol.266, issue.1/2, pp.37-56, 2004.
DOI : 10.1023/B:MCBI.0000049134.69131.89

M. Valko, D. Leibfritz, and J. Moncol, Free radicals and antioxidants in normal physiological functions and human disease, The International Journal of Biochemistry & Cell Biology, vol.39, issue.1, pp.44-84, 2007.
DOI : 10.1016/j.biocel.2006.07.001

A. Acharya, I. Das, D. Chandhok, and T. Saha, Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential, Oxidative Medicine and Cellular Longevity, vol.3, issue.1, pp.23-34, 2010.
DOI : 10.4161/oxim.3.1.10095

L. Pham-huy, H. He, and C. Pham-huy, Free radicals, antioxidants in disease and health, Int J Biomed Sci, vol.4, pp.89-96, 2008.

M. Fransen, M. Nordgren, B. Wang, and O. Apanasets, Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1822, issue.9, pp.1363-73, 2012.
DOI : 10.1016/j.bbadis.2011.12.001

M. Valko, C. Rhodes, and J. Moncol, Free radicals, metals and antioxidants in oxidative stress-induced cancer, Chemico-Biological Interactions, vol.160, issue.1, pp.1-40, 2006.
DOI : 10.1016/j.cbi.2005.12.009

W. Huang, Y. Cai, and Y. Zhang, Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention, Nutrition and Cancer, vol.59, issue.1, pp.1-20, 2010.
DOI : 10.1080/01635580701420616

R. Talhouk, C. Karam, and S. Fostok, Anti-Inflammatory Bioactivities in Plant Extracts, Journal of Medicinal Food, vol.10, issue.1, pp.1-10, 2007.
DOI : 10.1089/jmf.2005.055

Y. Cai, Q. Luo, M. Sun, and H. Corke, Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer, Life Sciences, vol.74, issue.17, pp.2157-84, 2004.
DOI : 10.1016/j.lfs.2003.09.047

L. Zhang, A. Ravipati, and S. Koyyalamudi, Antioxidant and Anti-inflammatory Activities of Selected Medicinal Plants Containing Phenolic and Flavonoid Compounds, Journal of Agricultural and Food Chemistry, vol.59, issue.23, pp.12361-67, 2011.
DOI : 10.1021/jf203146e

S. Dragland, H. Senoo, and W. K. , Several culinary and medicinal herbs are important sources of dietary antioxidants, J Nutr, vol.133, pp.1286-90, 2003.

T. Ozen, Z. Cöllü, and H. Korkmaz, Root, Seed, Flower, and Leaf Extract, Journal of Medicinal Food, vol.13, issue.5, pp.1224-1255, 2010.
DOI : 10.1089/jmf.2009.1303

H. Choi, H. Seo, and S. Kim, Anti-inflammatory and anti-proliferative effects of Rhus verniciflua Stokes in RAW264.7 cells, Molecular Medicine Reports, vol.9, issue.1, pp.311-326, 2014.
DOI : 10.3892/mmr.2013.1775

H. Choi, H. Seo, and S. Kim, Anti-inflammatory and anti-proliferative effect of herbal medicines (APR) in RAW264.7 cells, Molecular Medicine Reports, vol.9, issue.5, pp.1569-74, 2014.
DOI : 10.3892/mmr.2014.2033

J. Edwards, P. Brown, and N. Talent, A review of the chemistry of the genus Crataegus, Phytochemistry, vol.79, pp.5-26, 2012.
DOI : 10.1016/j.phytochem.2012.04.006

M. Tassell, R. Kingston, and D. Gilroy, Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease, Pharmacogn Rev, vol.4, pp.32-41, 2010.

D. Kumar, V. Arya, and Z. Qar, The genus Crataegus: chemical and pharmacological perspectives, Revista Brasileira de Farmacognosia, vol.22, issue.5, pp.1187-200, 2012.
DOI : 10.1590/S0102-695X2012005000094
URL : http://www.scielo.br/pdf/rbfar/v22n5/aop05712.pdf

D. Scudiero, R. Shoemaker, and K. Paull, Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines, Cancer Res, vol.48, pp.4827-4860, 1988.

T. Schmittgen and K. Livak, Analyzing real-time PCR data by the comparative CT method, Nature Protocols, vol.2, issue.6, pp.1101-1119, 2008.
DOI : 10.1593/neo.07916

F. Khan, M. Khan, F. Aziz, and A. Ke, Inflammation and acute phase response, Int J Appl Biol Pharm Technol Page, vol.1, pp.312-333, 2010.

D. Wang and R. Dubois, PROSTAGLANDINS AND CANCER, Gut, vol.55, issue.1, pp.115-137, 2006.
DOI : 10.1136/gut.2004.047100

A. Greenhough, H. Smartt, and A. Moore, The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment, Carcinogenesis, vol.30, issue.3, pp.377-86, 2009.
DOI : 10.1093/carcin/bgp014

S. Hosseinzadeh, A. Jafarikukhdan, A. Hosseini, and A. R. , The Application of Medicinal Plants in Traditional and Modern Medicine: A Review of <i>Thymus vulgaris</i>, International Journal of Clinical Medicine, vol.06, issue.09, pp.635-677, 2015.
DOI : 10.4236/ijcm.2015.69084

I. Ahmad, Z. Mehmood, and F. Mohammad, Screening of some Indian medicinal plants for their antimicrobial properties, Journal of Ethnopharmacology, vol.62, issue.2, pp.183-93, 1998.
DOI : 10.1016/S0378-8741(98)00055-5

E. Abdallah, A. Khalid, and N. Ibrahim, Antibacterial activity of oleo-gum resins of Commiphora molmol and Boswellia papyrifera against methicillin resistant Staphylococcus aureus (MRSA), Sci Res Essays, vol.4, pp.351-56, 2009.

M. Cowan, Plant products as antimicrobial agents, Clin Microbiol Rev, vol.12, pp.564-82, 1999.

T. Rahman, I. Hosen, M. Islam, and H. Shekhar, Oxidative stress and human health, Advances in Bioscience and Biotechnology, vol.03, issue.07, pp.997-1019, 2012.
DOI : 10.4236/abb.2012.327123

A. Schetter, N. Heegaard, and C. Harris, Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways, Carcinogenesis, vol.31, issue.1, pp.37-49, 2010.
DOI : 10.1093/carcin/bgp272
URL : https://academic.oup.com/carcin/article-pdf/31/1/37/7095043/bgp272.pdf

O. Aiyegoro and A. Okoh, Preliminary phytochemical screening and In vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC, BMC Complementary and Alternative Medicine, vol.80, issue.6473, p.21, 2010.
DOI : 10.1002/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.0.CO;2-7

F. Adediwura and A. Ayotunde, Phytochemical and pharmacognostic studies of telosma africanum, Br) colville leaf and stem. IJPSR, 2012.

K. Khandelwal, A text book of practical Pharmacognosy, 2005.

A. Siddiqui and A. M. , Practical pharmaceutical chemistry, 1997.

A. Rani, K. Singh, P. Ahuja, and S. Kumar, Molecular regulation of catechins biosynthesis in tea [Camellia sinensis (L.) O. Kuntze], Gene, vol.495, issue.2, pp.205-215, 2012.
DOI : 10.1016/j.gene.2011.12.029

D. Krishnaiah, T. Devi, A. Bono, and R. Sarbatly, Studies on phytochemical constituents of six Malaysian medicinal plants, J Med Plants Res, vol.3, pp.67-72, 2009.

M. Mir-derikvand, J. Sierra, and K. Ruel, Redirection of the phenylpropanoid pathway to feruloyl malate in Arabidopsis mutants deficient for cinnamoyl-CoA reductase 1, Planta, vol.57, issue.2, pp.943-56, 2008.
DOI : 10.1104/pp.106.4.1623
URL : https://hal.archives-ouvertes.fr/hal-00303861

L. Hofseth and M. Wargovich, Inflammation, cancer, and targets of ginseng, J Nutr, vol.137, pp.183-185, 2007.

J. Forman, H. Torres, and M. , Redox signaling in macrophages, Molecular Aspects of Medicine, vol.22, issue.4-5, pp.189-216, 2001.
DOI : 10.1016/S0098-2997(01)00010-3

M. Valko, M. Izakovic, M. Mazur, C. Rhodes, and J. Telser, Role of oxygen radicals in DNA damage and cancer incidence, Molecular and Cellular Biochemistry, vol.266, issue.1/2, pp.37-56, 2004.
DOI : 10.1023/B:MCBI.0000049134.69131.89

M. Valko, D. Leibfritz, J. Moncol, M. Cronin, M. Mazur et al., Free radicals and antioxidants in normal physiological functions and human disease, The International Journal of Biochemistry & Cell Biology, vol.39, issue.1, pp.44-84, 2007.
DOI : 10.1016/j.biocel.2006.07.001

P. Pacher, J. Beckman, and L. Liaudet, Nitric Oxide and Peroxynitrite in Health and Disease, Physiological Reviews, vol.87, issue.1, pp.315-424, 2006.
DOI : 10.1152/physrev.00029.2006

M. Valko, C. Rhodes, J. Moncol, M. Izakovic, and M. Mazur, Free radicals, metals and antioxidants in oxidative stress-induced cancer, Chemico-Biological Interactions, vol.160, issue.1, 2006.
DOI : 10.1016/j.cbi.2005.12.009

L. Pham-huy, H. He, and C. Pham-huy, Free radicals, antioxidants in disease and health, Int J Biomed Sci, vol.4, pp.89-96, 2008.

W. Li, Y. Sun, X. Yan, S. Yang, S. Kim et al., Anti-inflammatory and antioxidant activities of phenolic compounds from Desmodium caudatum leaves and stems, Archives of Pharmacal Research, vol.47, issue.6, pp.721-728, 2014.
DOI : 10.1007/s10600-011-9936-y

R. Talhouk, C. Karam, S. Fostok, W. El-jouni, and E. Barbour, Anti-Inflammatory Bioactivities in Plant Extracts, Journal of Medicinal Food, vol.10, issue.1, 2007.
DOI : 10.1089/jmf.2005.055

L. Zhang, A. Ravipati, S. Koyyalamudi, S. Jeong, N. Reddy et al., Antioxidant and Anti-inflammatory Activities of Selected Medicinal Plants Containing Phenolic and Flavonoid Compounds, Journal of Agricultural and Food Chemistry, vol.59, issue.23, pp.12361-12368, 2011.
DOI : 10.1021/jf203146e

S. Adebayo, J. Dzoyem, L. Shai, and J. Eloff, The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African, BMC Complementary and Alternative Medicine, vol.60, issue.8, pp.159-169, 2015.
DOI : 10.1016/S0031-9422(02)00065-1

O. Said, K. Khalil, S. Fulder, and H. Azaizeh, Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region, Journal of Ethnopharmacology, vol.83, issue.3, pp.251-65, 2002.
DOI : 10.1016/S0378-8741(02)00253-2

E. Lev and Z. Amar, Ethnopharmacological survey of traditional drugs sold in the Kingdom of Jordan, Journal of Ethnopharmacology, vol.82, issue.2-3, pp.131-176, 2002.
DOI : 10.1016/S0378-8741(02)00182-4

E. Marc, A. Nelly, D. Annick, and F. D. , Plants used as remedies antirheumatic and antineuralgic in the traditional medicine of Lebanon, Journal of Ethnopharmacology, vol.120, issue.3, pp.315-349, 2008.
DOI : 10.1016/j.jep.2008.08.024

E. Abourashed, A. El-alfy, I. Khan, and L. Walker, Ephedra in perspective - a current review, Phytotherapy Research, vol.37, issue.19, pp.703-715, 2003.
DOI : 10.1248/cpb.31.2359

T. Dinis, V. Maderia, and L. Almeida, Action of Phenolic Derivatives (Acetaminophen, Salicylate, and 5-Aminosalicylate) as Inhibitors of Membrane Lipid Peroxidation and as Peroxyl Radical Scavengers, Archives of Biochemistry and Biophysics, vol.315, issue.1, pp.161-170, 1994.
DOI : 10.1006/abbi.1994.1485

D. Scudiero, R. Shoemaker, K. Paull, A. Monks, S. Tierney et al., Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines, Cancer Res, vol.48, pp.4827-4860, 1988.

T. Schmittgen and K. Livak, Analyzing real-time PCR data by the comparative CT method, Nature Protocols, vol.2, issue.6, pp.1101-1109, 2008.
DOI : 10.1593/neo.07916

N. Ashley, Z. Weil, and R. Nelson, Inflammation: Mechanisms, Costs, and Natural Variation, Annual Review of Ecology, Evolution, and Systematics, vol.43, issue.1, pp.385-406, 2012.
DOI : 10.1146/annurev-ecolsys-040212-092530

M. Cowan, Plant products as antimicrobial agents, Clin Microbiol Rev, vol.12, pp.564-82, 1999.

T. Rahman, I. Hosen, M. Islam, and H. Shekhar, Oxidative stress and human health, Advances in Bioscience and Biotechnology, vol.03, issue.07, pp.997-1019, 2012.
DOI : 10.4236/abb.2012.327123

O. Aiyegoro and A. Okoh, Preliminary phytochemical screening and In vitro antioxidant activities of the aqueous extract of Helichrysum longifolium DC, BMC Complementary and Alternative Medicine, vol.80, issue.6473, pp.10-1186, 2010.
DOI : 10.1002/(SICI)1097-0010(20000515)80:7<985::AID-JSFA572>3.0.CO;2-7

K. Khandelwal, A text book of practical Pharmacognosy, 2005.

A. Siddiqui and A. M. , Practical pharmaceutical chemistry, 1997.

A. Rani, K. Singh, P. Ahuja, and S. Kumar, Molecular regulation of catechins biosynthesis in tea [Camellia sinensis (L.) O. Kuntze], Gene, vol.495, issue.2, 2012.
DOI : 10.1016/j.gene.2011.12.029

D. Krishnaiah, T. Devi, A. Bono, and R. Sarbatly, Studies on phytochemical constituents of six Malaysian medicinal plants, J Med Plants Res, vol.3, pp.67-72, 2009.

B. 1. Belpaire, F. M. Bogaert, and M. G. , THE FATE OF XENOBIOTICS IN LIVING ORGANISMS, Practical Medicinal Chemistry. Academic press, pp.501-515, 2003.
DOI : 10.1016/B978-012744481-9/50034-9

P. Koshy, Antimicrobial activity of some medicinal plants from Malaysia

P. Fyhrquist, Traditional medicinal uses and biological activities of some plant extracts of African Combretum Loefl., Terminalia L.and Pteleopsis Engl. species (Combretaceae) Academic dissertation, 2007.

R. Abu-dahab and F. Afifi, Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7), Scientia Pharmaceutica, vol.75, issue.3, pp.121-136, 2007.
DOI : 10.3797/scipharm.2007.75.121

M. Charles, Elevating Antioxidant Levels in Food through Organic Farming and Food Processing. An Organic Center State of Science Review, 2005.

D. O. Kennedy and E. L. Wightman, Advances in nutrition, pp.32-50, 2011.

A. Scalbert and G. Williamson, Dietary intake and bioavailability of polyphenols, J Nutr, vol.130, pp.2073-85, 2000.

S. Egert and G. Rimbach, Which Sources of Flavonoids: Complex Diets or Dietary Supplements?, Advances in Nutrition: An International Review Journal, vol.2, issue.1, 2011.
DOI : 10.3945/an.110.000026
URL : http://advances.nutrition.org/content/2/1/8.full.pdf

R. R. Huxley and H. A. Neil, The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies, European Journal of Clinical Nutrition, vol.57, issue.8
DOI : 10.1038/sj.ejcn.1601624

J. W. Erdman, Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, J. Nutr, vol.1373, pp.718-737, 2007.

Y. Lin, R. Shi, X. Wang, and M. Shen, Current Cancer Drug Targets, pp.634-646, 2008.

N. Ta and T. Walle, Aromatase inhibition by bioavailable methylated flavones, The Journal of Steroid Biochemistry and Molecular Biology, vol.107, issue.1-2, pp.127-136, 2007.
DOI : 10.1016/j.jsbmb.2007.01.006
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2024906/pdf

M. A. El-mahdy, Naringenin Protects HaCaT Human Keratinocytes Against UVB-induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome, Photochemistry and Photobiology, vol.601, issue.2, pp.307-323, 2008.
DOI : 10.1016/j.mrfmmm.2006.06.003

S. J. Hosseinimehr and A. Nemati, Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells, The British Journal of Radiology, vol.79, issue.941, pp.415-423, 2006.
DOI : 10.1259/bjr/40692384

S. N. Saldanha and T. O. Tollefsbol, The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes The phytoestrogen genistein produces acute nitric oxidedependent dilation of human forearm vasculature with similar potency to 17beta- estradiol, J Oncol. Circulation, vol.103, issue.2, pp.258-62, 2001.

J. Wang and G. Mazza, Inhibitory Effects of Anthocyanins and Other Phenolic Compounds on Nitric Oxide Production in LPS/IFN-??-Activated RAW 264.7 Macrophages, Journal of Agricultural and Food Chemistry, vol.50, issue.4, pp.850-857, 2002.
DOI : 10.1021/jf010976a

M. H. Oak, Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK Bioprotective Alkaloids of Grass- Fungal Endophyte Symbioses, Br J Pharmacol. J. Plant Physiol, vol.149114, issue.31, pp.283-901, 1997.

A. A. Watson, Polyhydroxylated alkaloids????? natural occurrence and therapeutic applications, Phytochemistry, vol.56, issue.3, pp.265-95, 2001.
DOI : 10.1016/S0031-9422(00)00451-9

M. Blumenthal, P. King, M. Huang, and E. , Ancient herb, modern medicine, regulatory dilemma; A review of the botany, chemistry, medicinal uses, safety concerns, and legal status of Ephedra and its alkaloids The origin and function of some methyl groups in branched-chain fatty acids, plant sterols and quinones, J. Herbal Gram Biochem J, vol.93, issue.3, pp.449-68, 1964.

M. Gordaliza, Synthetic Strategies to Terpene Quinones/Hydroquinones, Marine Drugs, vol.6, issue.12, pp.358-402, 2012.
DOI : 10.1007/s10126-002-0098-6
URL : http://www.mdpi.com/1660-3397/10/2/358/pdf

M. S. Ali-shtayeh and R. M. Jamous, Herbal preparation use by patients suffering from cancer in Palestine, Complementary Therapies in Clinical Practice, vol.17, issue.4, 2011.
DOI : 10.1016/j.ctcp.2011.06.002

K. Jennifer, Medicinal plants for livestock beneficial or toxic, p.52, 2000.

H. Azazieh, B. Saad, E. Cooper, O. T. Said, P. C. Li et al., Traditional Arabic and Islamic Medicine, a Re-emerging Health Aid. Evid Based Complement Epub ahead of print From traditional Chinese medicine to rational cancer therapy, Alternat. Med. J. Trends Mol. Med, vol.13, pp.353-361, 2007.

M. A. Richardson, Biopharmacologic and herbal therapies for cancer: research update from NCCAM, J Nutr, issue.13111, pp.3037-3077, 2001.

A. L. Harvey, Natural products in drug discovery, Drug Discovery Today, vol.13, issue.19-20, pp.894-901, 2008.
DOI : 10.1016/j.drudis.2008.07.004

T. Ibrahim, Pathogenesis of osteoblastic bone metastases from prostate cancer In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer, Cancer. J Ethnopharmacol, vol.116, issue.61, pp.1406-1424, 2004.

A. Sehgal, Anticancer Drug Discovery using Chemical Genomics, Current Medicinal Chemistry, vol.10, issue.9, pp.749-55, 2003.
DOI : 10.2174/0929867033457764

M. Ahmed, Traditional medicinal plants research in Egypt: Studies of antioxidant and anticancer activities, J. Medicinal Plants Research, vol.6, issue.5, pp.689-703, 2012.

H. Zaid, M. Silbermann, E. Ben-arye, and B. E. Saad, Greco-Arab and Islamic Herbal-Derived Anticancer Modalities, From Tradition to Molecular Mechanisms. Evidence-Based Complementary and Alternative Medicine Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis, World health Organization. Cancer J. Nat Med, vol.2012, issue.36 110, pp.1046-51, 1995.
DOI : 10.1155/2012/349040
URL : http://doi.org/10.1155/2012/349040

M. M. Gottesman, How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture, Cancer Res, vol.53, issue.154, pp.747-54, 1993.

S. Madhuri and . G. Pandey, Some anticancer medicinal plants of foreign origin, J. Current Sci, issue.6, pp.96-779, 2009.

L. Panizzi, Composition and antimicrobial properties of essential oils of four Mediterranean Lamiaceae, Journal of Ethnopharmacology, vol.39, issue.3, pp.167-70, 1993.
DOI : 10.1016/0378-8741(93)90032-Z

E. Ben-arye, Is a biopsychosocial???spiritual approach relevant to cancer treatment? A study of patients and oncology staff members on issues of complementary medicine and spirituality, Supportive Care in Cancer, vol.8, issue.12, pp.14147-52, 2006.
DOI : 10.1016/S0095-4543(05)70314-6

F. Tas, The prevalence and determinants of the use of complementary and alternative medicine in adult Turkish cancer patients, Acta Oncologica, vol.319, issue.2, pp.161-168, 2005.
DOI : 10.7326/0003-4819-101-1-105

F. U. Afifi, The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan, Complementary Therapies in Clinical Practice, vol.16, issue.4, pp.208-1281, 2006.
DOI : 10.1016/j.ctcp.2010.05.001

R. E. Genc, Complementary and Alternative Medicine Used by Pediatric Patients With Cancer in Western Turkey, Oncology Nursing Forum, vol.36, issue.3, pp.159-64, 2009.
DOI : 10.1188/09.ONF.E159-E164

U. S. Vainio, H. Weiderpass, and E. , Fruit and Vegetables in Cancer Prevention, Nutrition and Cancer, vol.54, issue.1, pp.111-153, 1997.
DOI : 10.1207/s15327914nc5401_13

N. C. Institute, Diet, nutrition, and cancer prevention: a guide to food choices, 1987.

A. Amin, Overview of major classes of plant-derived anticancer drugs, Int J Biomed Sci, vol.5, issue.1, pp.1-11, 2009.

Q. Zhu, Effects of Soybean Extract on Morphology and Survival of Caco-2, SW620, and HT-29 Cells, Nutrition and Cancer, vol.42, issue.1, pp.131-171, 2002.
DOI : 10.1207/S15327914NC421_18

P. J. Rijken, Effect of vegetable and carotenoid consumption on aberrant crypt multiplicity, a surrogate end-point marker for colorectal cancer in azoxymethane-induced rats, Carcinogenesis, vol.20, issue.12, pp.2267-72, 1999.
DOI : 10.1093/carcin/20.12.2267

D. J. Hryb, M. S. Khan, N. A. Romas, and W. Rosner, on the Interaction of SHBG with its Receptor on Human Prostatic Membranes, Planta Medica, vol.61, issue.01, pp.31-33, 1995.
DOI : 10.1055/s-2006-957993

E. Giovannucci, Tomatoes, Tomato-Based Products, Lycopene, and Cancer, Journal of the National Cancer Institute, vol.91, issue.4, 1999.

B. Halliwell, Tell me about free radicals, doctor: a review, J R Soc Med, vol.82, issue.12, pp.747-52, 1989.

Q. Ni, Seasonal Variations of the Antioxidant Composition in Ground Bamboo Sasa argenteastriatus Leaves, International Journal of Molecular Sciences, vol.181, issue.12, pp.2249-62, 2012.
DOI : 10.1016/j.foodres.2010.12.016

F. A. Carey, R. J. Sundberg, and C. Hancock, Advanced Organic Chemistry Part A: Structure and Mechanisms, Biochemical and Biophysical Research Communications, p.232833, 1997.

G. Burnett, G. Cameron, and S. Joiner, Faraday Trans. 1, J. Chem. Soc, pp.322-327, 1973.

S. Lomnicki, Copper Oxide-Based Model of Persistent Free Radical Formation on Combustion-Derived Particulate Matter, Environmental Science & Technology, vol.42, issue.13, pp.424982-424990, 2008.
DOI : 10.1021/es071708h

M. D. Hurley, C(O) Radicals, The Journal of Physical Chemistry A, vol.110, issue.45, pp.12443-12450, 2006.
DOI : 10.1021/jp064029m
URL : https://hal.archives-ouvertes.fr/hal-00110384

A. Boveris, Biochemistry of free radicals: from electrons to tissues, J. Medicina (B Aires, vol.58, issue.4, pp.350-356, 1998.

T. Ramakrishnan, P. S. Murthy, and K. P. Gopinathan, Intermediary metabolism of mycobacteria, J. Bacteriol Rev, vol.36, issue.1, pp.65-108, 1972.

A. M. Shah and K. M. Channon, Free radicals and redox signalling in cardiovascular disease, Heart, vol.90, issue.5, pp.486-493, 2004.
DOI : 10.1136/hrt.2003.029389
URL : http://heart.bmj.com/content/heartjnl/90/5/486.full.pdf

B. Halliwell, Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?, The Lancet, vol.344, issue.8924, pp.721-725, 1994.
DOI : 10.1016/S0140-6736(94)92211-X

E. Cadenas, Mitochondrial free radical production and cell signaling, Molecular Aspects of Medicine, vol.25, issue.1-2, pp.17-26, 2004.
DOI : 10.1016/j.mam.2004.02.005

E. Cadenas and K. J. Davies, Mitochondrial free radical generation, oxidative stress, and aging, J. Free Radic Biol Med, vol.29, pp.3-4222, 2000.

J. Du and J. M. Gebicki, Proteins are major initial cell targets of hydroxyl free radicals, The International Journal of Biochemistry & Cell Biology, vol.36, issue.11, pp.2334-2377, 2004.
DOI : 10.1016/j.biocel.2004.05.012

B. K. Siesjo, C. D. Agardh, and F. Bengtsson, Free radicals and brain damage, J. Cerebrovasc Brain Metab Rev, vol.1, issue.3, pp.165-211, 1989.

D. Harman, Aging: A Theory Based on Free Radical and Radiation Chemistry, Journal of Gerontology, vol.11, issue.3, pp.298-300, 1956.
DOI : 10.1093/geronj/11.3.298
URL : http://info-centre.jenage.de/assets/pdfs/library/harman-JOURNAL_OF_GERONTOLOGY-07_1956.pdf

T. Liu, The isoprostanes: Novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid, Journal of Biomedical Science, vol.23, issue.suppl, pp.226-261, 1999.
DOI : 10.1016/S0025-6196(12)64862-9

A. N. Mal-'tsev, A. A. Grekova, and E. A. Kits, Effect of emotional painful stress on affinity of blood to oxygen, on the antioxidant system and physical properties of the hepatocyte microsomal membrane, J. Biomed Khim, vol.56, issue.3, pp.360-72, 2010.

J. F. Turrens, Mitochondrial formation of reactive oxygen species, The Journal of Physiology, vol.552, issue.2, pp.335-379, 2003.
DOI : 10.1113/jphysiol.2003.049478

G. Ray and S. A. Husain, Oxidants, antioxidants and carcinogenesis, Indian J Exp Biol, vol.40, issue.11, pp.1213-1245, 2002.

C. Nishigori, Y. Hattori, and S. Toyokuni, Role of Reactive Oxygen Species in Skin Carcinogenesis, Antioxidants & Redox Signaling, vol.6, issue.3, pp.561-70, 2004.
DOI : 10.1089/152308604773934314

S. J. Stohs and D. Bagchi, Oxidative mechanisms in the toxicity of metal ions, Free Radical Biology and Medicine, vol.18, issue.2, pp.321-357, 1995.
DOI : 10.1016/0891-5849(94)00159-H

E. Birben, Oxidative Stress and Antioxidant Defense, World Allergy Organization Journal, vol.5, issue.1, 2012.
DOI : 10.1097/WOX.0b013e3182439613

M. Valko, Free radicals and antioxidants in normal physiological functions and human disease, The International Journal of Biochemistry & Cell Biology, vol.39, issue.1, pp.44-84, 2007.
DOI : 10.1016/j.biocel.2006.07.001

L. A. Pham-huy, H. He, and C. Pham-huy, Free radicals, antioxidants in disease and health, Int J Biomed Sci, vol.4, issue.2, pp.89-96, 2008.

Z. W. Ye, Oxidative stress Role of H(2)O(2) in hypertension, renin-angiotensin system activation and renal medullary disfunction caused by angiotensin II Carotenoids and Human Health Basic biochemical mechanisms behind the health benefits of polyphenols The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ, J. Biochim Biophys Acta. Br J Pharmacol. Mol Aspects Med. Biochim Biophys Acta, vol.1850166311808, issue.8712, pp.1607-212386, 2010.

K. M. Kulmatycki and F. Jamali, Drug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response, J Pharm Sci, vol.9, issue.3, pp.292-306, 2006.

N. A. Punchard, C. J. Whelan, and I. Adcock, The Journal of Inflammation, Journal of Inflammation, vol.1, issue.1, p.1, 2004.
DOI : 10.1186/1476-9255-1-1

P. C. Calder, Polyunsaturated fatty acids and inflammation, Biochemical Society Transactions, vol.33, issue.2, pp.423-430, 2005.
DOI : 10.1042/BST0330423

V. Kumar, Robbins and Cotran Pathologic Basis of Disease, Professional Edition E-Book, 2014.

P. E. Lipsky, Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed? 57 95. https://www.researchgate.net/figure/227743687_fig1_Figure-2-The-l-arginine- nitric-oxide-pathway-NO-is-synthesized-from-l-arginine-and, J Rheumatol, vol.56, pp.25-30, 1999.

A. E. Proudfoot, CHEMOKINE RECEPTORS: MULTIFACETED THERAPEUTIC TARGETS, Nature Reviews Immunology, vol.2, issue.2, pp.106-121, 2002.
DOI : 10.1038/29788

B. Moser, Chemokines: multiple levels of leukocyte migration control???, Trends in Immunology, vol.25, issue.2, pp.75-84, 2004.
DOI : 10.1016/j.it.2003.12.005

J. F. Bazan, A new class of membrane-bound chemokine with a CX3C motif, Nature, vol.385, issue.6617, pp.640-644, 1997.
DOI : 10.1038/385640a0

V. H. Bhaskar and V. Rajalakshmi, Anti-tumor activity of aqueous extract of Biophytum sensitivum Linn Annals of Biological Research, pp.76-80, 2010.

A. Dikshit, Aromatic plants a source of natural chemotherapeutants, J. Nat. Acad. Sci. Letters, vol.27, issue.5&6, pp.145-164, 2004.

H. Azaizeh, Traditional Arabic and Islamic Medicine, a Re-Emerging Health Aid, Evidence-Based Complementary and Alternative Medicine, vol.82, issue.2-3, pp.419-443, 2010.
DOI : 10.1016/S0378-8741(02)00182-4
URL : http://doi.org/10.1093/ecam/nen039

M. Nehme, Wild Flowers of Lebanon, National Council for Scientific Research, p.238, 1978.

A. B. Saleh and S. S. , Liban-La recherché phytoecologique: premiers resultants et perspectives, Ecologia Mediterranea, vol.16, pp.365-370, 1990.

P. Malychef, Les plantes medicinales au Liban. The Lebanese Med, J, vol.38, pp.59-60, 1989.

A. Chaar and C. I. , Medicinal plants of Lebanon. Archaeology and History in Lebanon, pp.70-85, 2004.

V. Arya and N. Thakur, Standardisation of Hawthorn fruits, J. Am Eurasian Sci, vol.7, issue.1, pp.16-22, 2012.

A. S. Shatoor, Acute and Sub-acute Toxicity of <i>Crataegus Aronia Syn. Azarolus</i> (L.) Whole Plant Aqueous Extract in Wistar Rats, American Journal of Pharmacology and Toxicology, vol.6, issue.2, pp.37-45, 2011.
DOI : 10.3844/ajptsp.2011.37.45

G. Tohme and H. Tohme, Illustrated Flora of Lebanon, second edition, CNRS, 2014.

M. Saadoudi, L. Hamebaba, and M. Abdeddaim, Study of the glucidicfraction of Celtis Australis L, Crataegus Azarolus L, Crataegus Monogyna Jacq., Elaeagnus Angustifolia L. and Zizyphus Lotus L. Fruits, J. World Acad Sci Eng Technol, vol.71, pp.1126-1129, 2012.

S. Ling, Effects of four medicinal herbs on human vascular endothelial cells in culture. Lipid status in healthy women, Int J Cardio, vol.111, pp.34-38, 2007.

S. Kultur, Medicinal plants used in K??rklareli Province (Turkey), Journal of Ethnopharmacology, vol.111, issue.2, pp.341-64, 2007.
DOI : 10.1016/j.jep.2006.11.035

A. Bouaziz, Phytotherapy of hypertension in Setif region (Eastern algeria) Proceedings book. The second African congress on biology and health, pp.39-42, 2012.

R. Bahri-sahloul, Polyphenol contents and antioxidant activities of extracts from flowers of two Crataegus azarolus L. varieties, Pak J Biol Sci, vol.12, issue.9, pp.660-668, 2009.

J. F. Morton, Major medicinal plants: botany, culture, and uses, 1977.

A. Y. Leung and S. Foster, Encyclopedia of common natural ingredients used in food, drugs, and cosmetics, 1996.

B. J. Gurley, S. F. Gardner, and M. A. Hubbard, Content versus label claims in ephedra-containing dietary supplements, Am J Health Syst Pharm, vol.57, pp.963-969, 2000.

D. Esiyok, S. Otles, and E. Akcicek, Herbs as a food source in Turkey, Asian Pac J Cancer Prev, vol.5, issue.3, pp.334-343, 2004.

K. Mathai, Nutrition in the Adult Years In Krause's Food, Nutrition, and Diet Therapy, pp.274-275, 2000.

M. Costa, Z. Zia, L. Davin, and N. Lewis, Toward Engineering the Metabolic Pathways of Cancer-Preventing Lignans in Cereal Grains and Other Crops, Recent Advances in Phytochemistry, Phytochemicals in Human Health Protection, Nutrition, and Plant Defense, pp.67-87, 1999.
DOI : 10.1007/978-1-4615-4689-4_4

A. King and G. Young, Characteristics and Occurrence of Phenolic Phytochemicals, Journal of the American Dietetic Association, vol.99, issue.2, pp.213-221, 1999.
DOI : 10.1016/S0002-8223(99)00051-6

B. Abu-irmaileh and F. U. Afifi, Herbal medicine in Jordan with special emphasis on commonly used herbs, Journal of Ethnopharmacology, vol.89, issue.2-3, pp.193-197, 2003.
DOI : 10.1016/S0378-8741(03)00283-6