Enregistrement d'Image Déformable en Groupe pour l'Estimation de Mouvement en Imagerie Médicale en 4D

Abstract : This doctoral thesis develops methods to estimate patient's motion, voluntary and involuntary (organs'motion), in order to correct for motion in spatiotemporal tomographic medical images. As an experimentalparadigm we consider the problem of motion estimation in Diffusion-Weighted Magnetic Resonance Imaging (DWI),an imaging modality sensitive to the diffusion of water molecules in the body. DWI is used for the evaluation oflymphoma patients, since water diffuses differently in healthy tissues and in lesions. The effect of water diffusioncan be better depicted through a parametric map, the so-called apparent diffusion coefficient (ADC map), createdbased on a series of DW images of the same patient (3D image sequence), acquired in time during scanning. Such aparametric map has the potentiality to become an imaging biomarker in DWI and provide physicians withcomplementary information to current state-of-the-art FDG-PET imaging reflecting quantitatively glycosemetaboslism.Our contributions are three fold. First, we propose a group-wise deformable image registration methodespecially designed for motion correction in DWI, as it is guided by a physiological model describing the diffusionprocess taking place during image acquisition. Our method derives an ADC map of higher accuracy in terms ofdepicting the gradient of the water molecules' diffusion in comparison to the corresponding map derived bycommon practice or by other model-free group-wise image registration methods. Second, we show that by imposingspatial constraints on the computation of the ADC map, the tumours in the image can be even better characterized interms of classifying them into the different types of the disease. Third, we show that a correlation between DWI andFDG-PET should exist by examining the correlation between statistical features extracted by the smooth ADC mapderived by our deformable registration method, and recommendation scores on the malignancy of the lesions, givenby experts based on an evaluation of the corresponding FDG-PET images of the patient.
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Submitted on : Tuesday, October 17, 2017 - 11:35:09 AM
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Evgenios Kornaropoulos. Enregistrement d'Image Déformable en Groupe pour l'Estimation de Mouvement en Imagerie Médicale en 4D. Autre. Université Paris-Saclay, 2017. Français. ⟨NNT : 2017SACLC042⟩. ⟨tel-01617929⟩

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