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Nano outils moléculaires biphotoniques pour le vivant

Abstract : Since decades, bioimaging technics increased a lot, thus leading to a better understanding of biologicalprocesses. However, the fluorescence imaging was limited due to the low photostability and brightnessof available organic dyes. In order to improve the lack of photostability and brightness of thecommercially available dyes, lots of effort was done by organic chemists. In the mean time with theincoming of nanotechnologies, new tools such as the semi-conductors QDs raised as promisingluminescent probes for bioimaging. Due to their intrinsic properties, QDs are bright and photostablenano-objects, furthermore, the labeling of the surface of the QDs is of interest for targeting (such asthe detection of cancer cells). Despite their popularity, with time, issues about the clearance and thetoxicity of the QDs have been adressed and are still not fully solved. So the development of safer andbiocompatible tools for bioimaging emerged as evidence for scientists. In that context, the use ofnanoparticles made of organic materials gain in interest and particularly the fluorescent organicnanoparticles (FONs). We aimed to propose biocompatible and safer alternative to QDs, so wedeveloped new nanotools, based on the self aggregation of propeller-shaped fluorophores as FONs.Because of the specific design of the chromophores, these FONs have large one and two-photonbrightness combine with good photostability. These features made these FONs promising tools foreither one-photon and two-photon fluorescence imaging in cells and in vivo.
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Submitted on : Thursday, November 23, 2017 - 11:37:20 AM
Last modification on : Saturday, June 16, 2018 - 3:11:03 AM


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  • HAL Id : tel-01616005, version 2



Jonathan Daniel. Nano outils moléculaires biphotoniques pour le vivant. Chimie organique. Université de Bordeaux, 2015. Français. ⟨NNT : 2015BORD0158⟩. ⟨tel-01616005v2⟩



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