Telomere length status of somatic cell sheep clones and their offspring, Molecular Reproduction and Development, vol.7, issue.12, pp.1525-1537, 2007. ,
DOI : 10.1016/j.bbaexp.2003.11.017
Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells, STEM CELLS, vol.69, issue.19, pp.661-673, 2010. ,
DOI : 10.1002/stem.307
A Meta-Analysis of Human Embryonic Stem Cells Transcriptome Integrated into a Web-Based Expression Atlas, Stem Cells, vol.22, issue.4, pp.961-973, 2007. ,
DOI : 10.1016/S0092-8674(00)80766-7
URL : https://hal.archives-ouvertes.fr/inserm-00128925
Senescence impairs successful reprogramming to pluripotent stem cells, Genes & Development, vol.23, issue.18, pp.2134-2139, 2009. ,
DOI : 10.1101/gad.1811609
Cellular senescence: putting the paradoxes in perspective, Current Opinion in Genetics & Development, vol.21, issue.1, pp.107-112, 2011. ,
DOI : 10.1016/j.gde.2010.10.005
Cellular senescence: when bad things happen to good cells, Nature Reviews Molecular Cell Biology, vol.441, issue.9, pp.729-740, 2007. ,
DOI : 10.1128/MCB.15.1.425
Molecules that Promote or Enhance Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells, Cell Stem Cell, vol.4, issue.4, pp.301-312, 2009. ,
DOI : 10.1016/j.stem.2009.03.005
Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence, STEM CELLS, vol.41, issue.4, pp.704-712, 2010. ,
DOI : 10.1089/clo.2004.6.217
Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells, Cell Stem Cell, vol.7, issue.2, pp.249-257, 2010. ,
DOI : 10.1016/j.stem.2010.06.015
Direct cell reprogramming is a stochastic process amenable to acceleration, Nature, vol.447, issue.7273, pp.595-601, 2009. ,
DOI : 10.1038/nature08592
Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues, Cell, vol.143, issue.4, pp.508-525, 2010. ,
DOI : 10.1016/j.cell.2010.10.008
Linking the p53 tumour suppressor pathway to somatic cell reprogramming, Nature, vol.24, issue.7259, pp.1140-1144, 2009. ,
DOI : 10.1016/j.exphem.2003.07.005
Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells, Science, vol.288, issue.5466, pp.665-669, 2000. ,
DOI : 10.1126/science.288.5466.665
The Ink4/Arf locus is a barrier for iPS cell reprogramming, Nature, vol.7, issue.7259, pp.1136-1139, 2009. ,
DOI : 10.1128/MCB.16.3.859
Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors, Cell Research, vol.18, issue.5, pp.600-603, 2008. ,
DOI : 10.1016/j.cell.2006.07.024
Recapitulation of premature ageing with iPSCs from Hutchinson???Gilford progeria syndrome, Nature, vol.4, issue.7342, pp.221-225, 2011. ,
DOI : 10.1038/nprot.2009.191
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity, Nature, vol.94, issue.7259, pp.1149-1153, 2009. ,
DOI : 10.1038/nature08287
Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells, Cell Stem Cell, vol.4, issue.2, pp.141-154, 2009. ,
DOI : 10.1016/j.stem.2008.12.010
Senescent phenotypes of skin fibroblasts from patients with Tangier disease, Biochemical and Biophysical Research Communications, vol.357, issue.2, pp.493-498, 2007. ,
DOI : 10.1016/j.bbrc.2007.03.172
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence, Molecular and Cellular Biology, vol.29, issue.16, pp.4495-4507, 2009. ,
DOI : 10.1128/MCB.01868-08
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence, Cell, vol.113, issue.6, pp.703-716, 2003. ,
DOI : 10.1016/S0092-8674(03)00401-X
Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence, PLoS Biology, vol.86, issue.5, 2007. ,
DOI : 10.1371/journal.pbio.0050110.st002
The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells, STEM CELLS, vol.461, issue.Spec No. 2, pp.721-733, 2010. ,
DOI : 10.4161/auto.4239
Linking functional decline of telomeres, mitochondria and stem cells during ageing, Nature, vol.120, issue.7288, pp.520-528, 2010. ,
DOI : 10.1038/nrc2731
Analysis of Telomere Length in Dolly, a Sheep Derived by Nuclear Transfer, Cloning, vol.1, issue.2, pp.119-125, 1999. ,
DOI : 10.1089/15204559950020003
Telomere dynamics in human cells reprogrammed to pluripotency, PLoS ONE, vol.4, 2009. ,
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Cell, vol.131, issue.5, pp.861-872, 2007. ,
DOI : 10.1016/j.cell.2007.11.019
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells, Nature, vol.445, issue.7259, pp.1145-1148, 2009. ,
DOI : 10.1038/nature08285
Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming, Regenerative Medicine, vol.80, issue.3, pp.345-363, 2010. ,
DOI : 10.1634/stemcells.2005-0214
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells, Science, vol.25, issue.10, pp.1917-1920, 2007. ,
DOI : 10.1038/nbt1335
Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences, Science, vol.26, issue.7, pp.797-801, 2009. ,
DOI : 10.1038/nbt1418
Chromatin Structure and Gene Expression Programs of Human Embryonic and Induced Pluripotent Stem Cells, Cell Stem Cell, vol.7, issue.2, pp.249-257, 2010. ,
DOI : 10.1016/j.stem.2010.06.015
Feeder-independent culture of human embryonic stem cells, Nature Methods, vol.746, issue.8, pp.637-646, 2006. ,
DOI : 10.1038/nmeth902
Senescent phenotypes of skin fibroblasts from patients with Tangier disease, Biochemical and Biophysical Research Communications, vol.357, issue.2, pp.493-498, 2007. ,
DOI : 10.1016/j.bbrc.2007.03.172
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence, Molecular and Cellular Biology, vol.29, issue.16, pp.4495-4507, 2009. ,
DOI : 10.1128/MCB.01868-08
The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells, STEM CELLS, vol.461, issue.Spec No. 2, pp.721-733, 2010. ,
DOI : 10.4161/auto.4239
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Cell, vol.131, issue.5, pp.861-872, 2007. ,
DOI : 10.1016/j.cell.2007.11.019
Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming, Regenerative Medicine, vol.80, issue.3, pp.345-363, 2010. ,
DOI : 10.1634/stemcells.2005-0214
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells, Science, vol.25, issue.10, pp.1917-1920, 2007. ,
DOI : 10.1038/nbt1335
Cela semble prétentieux ! Oui et pourquoi pas ? De temps en temps ça fait du bien ,
ont été comme une longue chute dans le vide où il n'y a ni parachute de soutien, ni de filet qui nous rattrapera, et dont on contemple impuissant chaque instant qui passe. Ce long parcours qui nous agite et nous possède Adepte de sports extrêmes et de sensations fortes, je peux dire que c'est un moment rare. Je ne dramatiserai rien, je n'angéliserai rien ,
il y a joué, quelle qu'en soit la forme. Cela me permet de ne plus avoir à citer G. Bachelard mais de le confirmer. Et surtout poursuivre mon chemin à faire ce que j ,