Développement d'un modèle d'étude du vieillissement tissulaire basé sur l'utilisation de cellules souches humaines à pluripotence induite par reprogrammation cellulaire.

Abstract : Beside the pathological context, time is the essential basis in the aging process of the body and associated systems. These will gradually introduce a decline in function(s) where many complex mechanisms will take part at different levels. Among proposed findings, aging is the result of an inevitable process, a succession of cellular stress that could be prevented or repaired, opening the way for future studies that will eventually offer an explanation detailed, clear and complete which occur. For example, our work provide a response element to establish a link between senescence and aging, based on the generation of hiPSCs by cellular reprogramming of cells from biopsies of young, older, senescent and proliferating cells patients. Further characterization of their pluripotent state comparable to that of human embryonic stem cells, we have also showed by a specific differentiation into fibroblasts, that cellular characteristics of those fibroblasts had erased aging features. Next step is to extend such study in cutaneous tissue model by the introduction of differentiation strategies in the epidermal lineage which will able us to better understand aging-associated diseases, and thus bring the ability to propose tools for an appropriate and concrete medicine to aged patients.
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Nafissa Ait Hamou. Développement d'un modèle d'étude du vieillissement tissulaire basé sur l'utilisation de cellules souches humaines à pluripotence induite par reprogrammation cellulaire.. Sciences du Vivant [q-bio]. UNIVERSITE MONTPELLIER I, 2016. Français. ⟨tel-01609669⟩

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