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10% fetal calf serum, 1% penicillin-streptomycin, 0.1% ?-mercaptoethanol, and 2% sodium pyruvate). HEK 293T cells were cultured for lentiviral production in DMEM/Glutamax-5% fetal bovine serum, 1 mM sodium pyruvate, MEM nonessential amino acids, and penicillin-streptomycin. All cell culture products were purchased from GIBCO/Life Technologies, Paisley, UK. Primary B-cells were extracted from the spleen of BALB/c mice by negative selection as previously described, Lack T-cell hybridoma, which recognizes I-A d-LACK 156-173 complexes, were cultured as reported previously, 2007. ,
B-cell culture medium supplemented with nonessential amino acids ,
F(ab?) 2 goat antimouse, F(ab?) 2 donkey anti-rabbit-Cy3, F(ab?) 2 goat anti-rabbit-Alexa Fluor 488, F(ab?) 2 donkey anti-rat-Cy5, streptavidin-Alexa Fluor, ), rabbit anti-?-tubulin (kindly provided by Michel Bornens, Institut Curie, vol.488 ,
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