G. H. Acheson, Physiology of neuro-muscular junctions; chemical aspects, Fed. Proc, vol.7, issue.3, pp.447-57, 1948.

C. Acuna, X. Liu, T. C. Su, C. Acuna, X. Liu et al., RIM-BPs Mediate Tight Coupling of Action Potentials to Ca2+-Triggered Neurotransmitter Release, Neuron, vol.87, issue.6, pp.1234-1247, 2015.
DOI : 10.1016/j.neuron.2015.08.027

C. Auger, S. Kondo, and A. Marty, Multivesicular release at single functional synaptic sites in cerebellar stellate and basket cells, J. Neurosci, vol.18, issue.12, pp.4532-4579, 1998.

C. Auger and A. Marty, Heterogeneity of Functional Synaptic Parameters among Single Release Sites, Neuron, vol.19, issue.1, pp.139-50, 1997.
DOI : 10.1016/S0896-6273(00)80354-2

V. Balakrishnan, S. P. Kuo, P. D. Roberts, and L. O. Trussell, Slow glycinergic transmission mediated by transmitter pooling, Nature Neuroscience, vol.93, issue.3, pp.286-94, 2009.
DOI : 10.1113/jphysiol.1991.sp018512

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664096

A. Barberis, C. Lu, S. Vicini, and J. W. Mozrzymas, Developmental Changes of GABA Synaptic Transient in Cerebellar Granule Cells, Molecular Pharmacology, vol.67, issue.4, pp.1221-1228, 2005.
DOI : 10.1124/mol.104.006437

B. Barbour and M. Häusser, Intersynaptic diffusion of neurotransmitter, Trends in Neurosciences, vol.20, issue.9, pp.377-384, 1997.

A. Biró, N. B. Holderith, and Z. Nusser, Release Probability-Dependent Scaling of the Postsynaptic Responses at Single Hippocampal GABAergic Synapses, Journal of Neuroscience, vol.26, issue.48, pp.12487-96, 2006.
DOI : 10.1523/JNEUROSCI.3106-06.2006

A. Blot and B. Barbour, Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceau, Nature Neuroscience, vol.68, issue.2, pp.289-295, 2014.
DOI : 10.1113/jphysiol.1952.sp004764

M. E. Blue and J. G. Parnavelas, The formation and maturation of synapses in the visual cortex of the rat. II. Quantitative analysis, Journal of Neurocytology, vol.150, issue.4, pp.697-712, 1983.
DOI : 10.1007/BF01181531

J. H. Bollmann, B. Sakmann, and J. G. Borst, Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal, Science, vol.289, issue.5481, pp.289-953, 2000.
DOI : 10.1126/science.289.5481.953

B. Bouhours, F. F. Trigo, and A. Marty, Somatic Depolarization Enhances GABA Release in Cerebellar Interneurons via a Calcium/Protein Kinase C Pathway, Journal of Neuroscience, vol.31, issue.15, pp.31-5804, 2011.
DOI : 10.1523/JNEUROSCI.5127-10.2011

T. Branco and K. Staras, The probability of neurotransmitter release: variability and feedback control at single synapses, Nature Reviews Neuroscience, vol.18, issue.5, pp.373-83, 2009.
DOI : 10.1523/JNEUROSCI.5745-03.2004

I. Bucurenciu, A. Kulik, B. Schwaller, M. Frotscher, and P. Jonas, Nanodomain Coupling between Ca2+ Channels and Ca2+ Sensors Promotes Fast and Efficient Transmitter Release at a Cortical GABAergic Synapse, Neuron, vol.57, issue.4, pp.536-581, 2008.
DOI : 10.1016/j.neuron.2007.12.026

URL : http://doi.org/10.1016/j.neuron.2007.12.026

J. M. Christie, D. N. Chiu, and C. E. Jahr, Ca2+-dependent enhancement of release by subthreshold somatic depolarization, Nature Neuroscience, vol.120, issue.1, pp.62-68, 2011.
DOI : 10.1016/0165-0270(91)90017-T

J. D. Clements and R. A. Silver, Unveiling synaptic plasticity: a new graphical and analytical approach, Trends in Neurosciences, vol.23, issue.3, pp.105-113, 2000.
DOI : 10.1016/S0166-2236(99)01520-9

R. Couteaux and M. Pécot-dechavassine, Synaptic vesicles and pouches at the level of " active zones " of the neuromuscular junction, C. R. Hebd. Séances Acad. Sci, issue.25, pp.271-2346, 1970.

E. D. De-robertis and H. S. Bennett, SOME FEATURES OF THE SUBMICROSCOPIC MORPHOLOGY OF SYNAPSES IN FROG AND EARTHWORM, The Journal of Cell Biology, vol.1, issue.1, pp.47-58, 1955.
DOI : 10.1083/jcb.1.1.47

D. Castillo, J. Engbaek, and L. , The nature of the neuromuscular block produced by magnesium, The Journal of Physiology, vol.124, issue.2, pp.370-84, 1954.
DOI : 10.1113/jphysiol.1954.sp005114

D. Castillo, J. Katz, and B. , Quantal components of the end-plate potential, The Journal of Physiology, vol.124, issue.3, pp.560-573, 1954.
DOI : 10.1113/jphysiol.1954.sp005129

D. Castillo, J. Katz, and B. , Localization of active spots within the neuromuscular junction of the frog, The Journal of Physiology, vol.132, issue.3, pp.630-649, 1956.
DOI : 10.1113/jphysiol.1956.sp005554

J. S. Dittman and W. G. Regehr, Calcium dependence and recovery kinetics of presynaptic depression at the climbing fiber to Purkinje cell synapse, J. Neurosci, vol.18, issue.16, pp.6147-62, 1998.

L. E. Dobrunz and C. F. Stevens, Heterogeneity of Release Probability, Facilitation, and Depletion at Central Synapses, Neuron, vol.18, issue.6, pp.995-1008, 1997.
DOI : 10.1016/S0896-6273(00)80338-4

J. Falk-vairant, P. Correges, L. Eder-colli, N. Salem, E. Roulet et al., Quantal acetylcholine release induced by mediatophore transfection., Proc. Natl. Acad. Sci, pp.93-5203, 1996.
DOI : 10.1073/pnas.93.11.5203

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC39222/pdf

B. Y. Fatt and B. Katz, Spontaneous subthreshold activity at motor nerve endings, J. Physiol, vol.117, pp.109-128, 1952.

N. Fredj, . Ben, and J. Burrone, A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse, Nature Neuroscience, vol.440, issue.6, pp.751-759, 2009.
DOI : 10.1038/nn.2317

M. Glitsch and A. Marty, Presynaptic effects of NMDA in cerebellar Purkinje cells and interneurons, J. Neurosci, vol.19, issue.2, pp.511-519, 1999.

S. Hallermann, A. Fejtova, H. Schmidt, A. Weyhersmüller, R. A. Silver et al., Bassoon Speeds Vesicle Reloading at a Central Excitatory Synapse, Neuron, vol.68, issue.4, pp.710-723, 2010.
DOI : 10.1016/j.neuron.2010.10.026

URL : http://doi.org/10.1016/j.neuron.2010.10.026

S. Hallermann and R. A. Silver, Sustaining rapid vesicular release at active zones: potential roles for vesicle tethering, Trends in Neurosciences, vol.36, issue.3, pp.185-194, 2013.
DOI : 10.1016/j.tins.2012.10.001

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748400

O. P. Hamill, A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pfl??gers Archiv - European Journal of Physiology, vol.12, issue.2, pp.85-100, 1981.
DOI : 10.1038/287447a0

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=

J. J. Harris, R. Jolivet, and D. Attwell, Synaptic Energy Use and Supply, Neuron, vol.75, issue.5, pp.762-777, 2012.
DOI : 10.1016/j.neuron.2012.08.019

URL : http://doi.org/10.1016/j.neuron.2012.08.019

V. Haucke, E. Neher, and S. J. Sigrist, Protein scaffolds in the coupling of synaptic exocytosis and endocytosis, Nature Reviews Neuroscience, vol.316, issue.3, pp.127-138, 2011.
DOI : 10.1126/science.1137395

DOI : 10.1083/jcb.57.2.315

N. Holderith, A. Lorincz, G. Katona, B. Rózsa, A. Kulik et al., Release probability of hippocampal glutamatergic terminals scales with the size of the active zone, Nature Neuroscience, issue.7, pp.15-988, 2012.

E. Holzmann, A. Freeman, and L. Kashner, Stimulation-Dependent Alterations in Peroxidase Uptake at Lobster Neuromuscular Junctions, Science, vol.20, pp.733-736, 1971.

F. T. Horrigan and R. J. Bookman, Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells, Neuron, vol.13, issue.5, pp.1119-1129, 1994.
DOI : 10.1016/0896-6273(94)90050-7

W. P. Hurlbut, N. Iezzi, and B. Ceccarelli, Correlation between quantal secretion and vesicle loss at the frog neuromuscular junction., The Journal of Physiology, vol.425, issue.1, pp.501-526, 1990.
DOI : 10.1113/jphysiol.1990.sp018115

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189860/pdf

J. J. Jack, S. J. Redman, and K. Wong, The components of synaptic potentials evoked in cat spinal motoneurones by impulses in single group Ia afferents., The Journal of Physiology, vol.321, issue.1, pp.65-96, 1981.
DOI : 10.1113/jphysiol.1981.sp013972

P. S. Kaeser and W. G. Regehr, Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release, Annual Review of Physiology, vol.76, issue.1, pp.333-63, 2014.
DOI : 10.1146/annurev-physiol-021113-170338

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503208

B. Katz, The release of neuronal transmitter substances Liverpool, 1969.

S. Kondo and A. Marty, Synaptic currents at individual connections among stellate cells in rat cerebellar slices, The Journal of Physiology, vol.494, issue.1, pp.221-232, 1998.
DOI : 10.1111/j.1469-7793.1997.509bj.x

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230939

H. Korn and D. S. Faber, Quantal analysis and synaptic efficacy in the CNS, Trends in Neurosciences, vol.14, issue.10, pp.439-445, 1991.
DOI : 10.1016/0166-2236(91)90042-S

M. E. Kriebel and C. E. Gross, Multimodal Distribution of Frog Miniature Endplate Potentials in Adult, Denervated, and Tadpole Leg Muscle, The Journal of General Physiology, vol.64, issue.1, pp.85-103, 1974.
DOI : 10.1085/jgp.64.1.85

M. Kuno, Quantal components of excitatory synaptic potentials in spinal motoneurones, The Journal of Physiology, vol.175, issue.1, pp.81-99, 1964.
DOI : 10.1113/jphysiol.1964.sp007504

J. S. Lee, W. Ho, and S. Lee, Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool, Proc. Natl. Acad. Sci, pp.765-74, 2012.
DOI : 10.1523/JNEUROSCI.4122-07.2007

I. Llano and H. M. Gerschenfeld, Inhibitory synaptic currents in stellate cells of rat cerebellar slices., The Journal of Physiology, vol.468, issue.1, pp.177-200, 1993.
DOI : 10.1113/jphysiol.1993.sp019766

I. Llano, A. Marty, C. M. Armstrong, and A. Konnerth, Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices., The Journal of Physiology, vol.434, issue.1, pp.183-213, 1991.
DOI : 10.1113/jphysiol.1991.sp018465

R. Llinás, I. Z. Steinberg, and K. Walton, Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse, Biophysical Journal, vol.33, issue.3, pp.323-351, 1981.
DOI : 10.1016/S0006-3495(81)84899-0

M. W. Miller, Maturation of rat visual cortex. III. Postnatal morphogenesis and synaptogenesis of local circuit neurons, Brain Research, vol.390, issue.2, pp.271-85, 1986.
DOI : 10.1016/S0006-8993(86)80236-0

S. Nagwaney, M. L. Harlow, J. H. Jung, J. Szule, D. Ress et al., Macromolecular connections of active zone material to docked synaptic vesicles and presynaptic membrane at neuromuscular junctions of mouse, The Journal of Comparative Neurology, vol.147, issue.5, pp.457-468, 2009.
DOI : 10.1093/oxfordjournals.jmicro.a023679

Y. Nakamura, H. Harada, N. Kamasawa, K. Matsui, J. S. Rothman et al., Nanoscale Distribution of Presynaptic Ca 2+ Channels and Its Impact on Vesicular Release during Development, Neuron, vol.85, issue.1, pp.145-58, 2015.
DOI : 10.1016/j.neuron.2014.11.019

E. Neher, What is rate-limiting during sustained synaptic activity: vesicle supply or the availability of release sites, Frontiers in Synaptic Neuroscience, vol.2, issue.2, p.144, 2010.
DOI : 10.3389/fnsyn.2010.00144

E. Neher and A. Marty, Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells., Proc. Natl. Acad. Sci, pp.79-6712, 1982.
DOI : 10.1073/pnas.79.21.6712

E. Neher and T. Sakaba, Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release, Neuron, vol.59, issue.6, pp.861-72, 2008.
DOI : 10.1016/j.neuron.2008.08.019

C. Pouzat and S. Hestrin, Developmental regulation of basket/stellate cell->Purkinje cell synapses in the cerebellum, J. Neurosci, vol.17, issue.23, pp.9104-9112, 1997.

D. Purves and J. W. Lichtman, Elimination of synapses in the developing nervous system, Science, vol.210, issue.4466, pp.210-153, 1980.
DOI : 10.1126/science.7414326

D. M. Ramirez, M. Khvotchev, B. Trauterman, and E. T. Kavalali, Vti1a Identifies a Vesicle Pool that Preferentially Recycles at Rest and Maintains Spontaneous Neurotransmission, Neuron, vol.73, issue.1, pp.73-121, 2012.
DOI : 10.1016/j.neuron.2011.10.034

URL : http://doi.org/10.1016/j.neuron.2011.10.034

S. Redman, Quantal analysis of synaptic potentials in neurons of the central nervous system, Physiological Reviews, vol.70, issue.1, pp.165-98, 1990.

S. Redman and B. Walmsley, Amplitude fluctuations in synaptic potentials evoked in cat spinal motoneurones at identified group Ia synapses., The Journal of Physiology, vol.343, issue.1, pp.135-145, 1983.
DOI : 10.1113/jphysiol.1983.sp014885

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193912/pdf

W. G. Regehr, Short-Term Presynaptic Plasticity, Cold Spring Harbor Perspectives in Biology, vol.4, issue.7, p.5702, 2012.
DOI : 10.1101/cshperspect.a005702

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385958

A. Ritzau-jost, I. Delvendahl, A. Rings, N. Byczkowicz, H. Harada et al., Ultrafast Action Potentials Mediate Kilohertz Signaling at a Central Synapse, Neuron, vol.84, issue.1, pp.152-163, 2014.
DOI : 10.1016/j.neuron.2014.08.036

URL : http://doi.org/10.1016/j.neuron.2014.08.036

S. O. Rizzoli and W. J. Betz, Synaptic vesicle pools, Nature Reviews Neuroscience, vol.21, issue.1, pp.57-69, 2005.
DOI : 10.1016/S0896-6273(01)00500-1

S. Rudolph, M. Tsai, H. Von-gersdorff, and J. I. Wadiche, The ubiquitous nature of multivesicular release, Trends in Neurosciences, vol.38, issue.7, pp.1-11, 2015.
DOI : 10.1016/j.tins.2015.05.008

T. Sakaba, Roles of the Fast-Releasing and the Slowly Releasing Vesicles in Synaptic Transmission at the Calyx of Held, Journal of Neuroscience, vol.26, issue.22, pp.5863-5871, 2006.
DOI : 10.1523/JNEUROSCI.0182-06.2006

T. Sakaba and E. Neher, Calmodulin Mediates Rapid Recruitment of Fast-Releasing Synaptic Vesicles at a Calyx-Type Synapse, Neuron, vol.32, issue.6, pp.1119-1131, 2001.
DOI : 10.1016/S0896-6273(01)00543-8

M. Scanziani, P. A. Salin, K. E. Vogt, R. C. Malenka, and R. A. Nicoll, Usedependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors, Nature, issue.6617, pp.385-630, 1997.
DOI : 10.1038/385630a0

T. Schikorski and C. F. Stevens, Quantitative ultrastructural analysis of hippocampal excitatory synapses, J. Neurosci, vol.17, issue.15, pp.5858-67, 1997.

R. Schneggenburger and E. Neher, Intracellular calcium dependence of transmitter release rates at a fast central synapse, Nature, issue.6798, pp.406-889, 2000.

R. Schneggenburger and C. Rosenmund, Molecular mechanisms governing Ca2+ regulation of evoked and spontaneous release, Nature Neuroscience, vol.158, issue.7, pp.935-941, 2015.
DOI : 10.1016/j.neuroscience.2008.03.028

J. Sheng, L. He, H. Zheng, L. Xue, F. Luo et al., Calciumchannel number critically influences synaptic strength and plasticity at the active zone, Nature, issue.7, pp.15-998, 2012.
DOI : 10.1038/nn.3129

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891200

F. J. Sigworth, The variance of sodium current fluctuations at the node of Ranvier, The Journal of Physiology, vol.307, issue.1, pp.97-129, 1980.
DOI : 10.1113/jphysiol.1980.sp013426

C. F. Stevens, Neurotransmitter Release at Central Synapses, Neuron, vol.40, issue.2, pp.381-388, 2003.
DOI : 10.1016/S0896-6273(03)00643-3

URL : http://doi.org/10.1016/s0896-6273(03)00643-3

C. F. Stevens and Y. Wang, Facilitation and depression at single central synapses, Neuron, vol.14, issue.4, pp.795-802, 1995.
DOI : 10.1016/0896-6273(95)90223-6

URL : http://doi.org/10.1016/0896-6273(95)90223-6

T. C. Südhof, The Presynaptic Active Zone, Neuron, vol.75, issue.1, pp.11-25, 2012.
DOI : 10.1016/j.neuron.2012.06.012

T. C. Südhof, Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle, Neuron, vol.80, issue.3, pp.675-690, 2013.
DOI : 10.1016/j.neuron.2013.10.022

J. Szule, M. L. Harlow, J. H. Jung, F. F. De-miguel, R. M. Marshall et al., Regulation of Synaptic Vesicle Docking by Different Classes of Macromolecules in Active Zone Material, PLoS ONE, vol.xxii, issue.3, 2012.
DOI : 10.1371/journal.pone.0033333.t001

J. C. Tapia, J. D. Wylie, N. Kasthuri, K. J. Hayworth, R. Schalek et al., Pervasive Synaptic Branch Removal in the Mammalian Neuromuscular System at Birth, Neuron, vol.74, issue.5, pp.74-816, 2012.
DOI : 10.1016/j.neuron.2012.04.017

J. Ting, T. Daigle, Q. Chen, and G. Feng, Acute Brain Slice Methods for Adult and Aging Animals: Application of Targeted Patch Clamp Analysis and Optogenetics, Methods Mol Biol, vol.1183, pp.1-21, 2014.
DOI : 10.1007/978-1-4939-1096-0_14

G. Tong and C. E. Jahr, Multivesicular release from excitatory synapses of cultured hippocampal neurons, Neuron, vol.12, issue.1, pp.51-59, 1994.
DOI : 10.1016/0896-6273(94)90151-1

F. F. Trigo, T. Sakaba, D. Ogden, and A. Marty, Readily releasable pool of synaptic vesicles measured at single synaptic contacts, Proc. Natl. Acad. Sci, 2012.
DOI : 10.1002/cne.21975

A. Triller and H. Korn, Transmission at a central inhibitory synapse. III. Ultrastructure of physiologically identified and stained terminals, J. Neurophysiol, vol.48, issue.3, pp.708-736, 1982.

Y. C. Yung, N. C. Stoddard, H. Mirendil, and J. Chun, Lysophosphatidic Acid Signaling in the Nervous System, Neuron, vol.85, issue.4, pp.669-682, 2015.
DOI : 10.1016/j.neuron.2015.01.009