Synaptic fluctuations in cerebellar interneurons connected by a single synaptic contact

Abstract : The unitary element of central synaptic transmission is a single synaptic site, with one active zone as presynaptic component and the postsynaptic density as postsynaptic partner. Due to technical limitations there is much uncertainty on the mode of functioning of a single synaptic site. To address this issue it is planned to perform paired recordings between interneurons of the molecular layers of the cerebellum. These neurons form synapses with a large quantal size, and occasionally displaying a single release site, and are thus favorable for this study. Postsynaptic responses will be studied in response to trains of presynaptic action potentials under various conditions. The results will be compared to a model supposing the obligatory binding of vesicles to a small complement of docking sites prior to exocytosis.
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María Camila Pulido Puentes. Synaptic fluctuations in cerebellar interneurons connected by a single synaptic contact. Neuroscience. Université Sorbonne Paris Cité, 2016. English. ⟨NNT : 2016USPCB007⟩. ⟨tel-01584465⟩

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