H. Sample, NH 2 CHO (right) observed spectral lines (black) in IRAS 4A and SVS13A (compact solution), and the spectra predicted by best fit LTE model (red), p.117

H. Sample, NH 2 CHO (right) observed spectral lines (black) in Cep E and OMC-2 FIR 4 (extended solutions), and the spectra predicted by best fit LTE model (red), p.118

L. Rotational-diagrams-for, L. Tmc-1, and L. , Data points are depicted in black. The red lines correspond to the best fit to the data points. The dashed vertical lines in the middle and right panels indicate the upper-level energy (35 K) at which the division of the 2-component fitting was made, IRAS 4A (middle), and I16293 (right), p.119

S. E. Bisschop, J. K. Jorgensen, E. F. Van-dishoeck, and E. B. De-wachter, Testing grain-surface chemistry in massive hot-core regions, Astronomy & Astrophysics, vol.465, issue.3, p.913, 2007.
DOI : 10.1051/0004-6361:20065963
URL : http://arxiv.org/abs/astro-ph/0702066

P. Caselli, T. I. Hasegawa, and E. Herbst, Chemical differentiation between star-forming regions - The Orion Hot Core and Compact Ridge, The Astrophysical Journal, vol.408, p.548, 1993.
DOI : 10.1086/172612

E. Gibb, A. Nummelin, W. M. Irvine, D. C. Whittet, and P. Bergman, Chemistry of the Organic???rich Hot Core G327.3???0.6, The Astrophysical Journal, vol.545, issue.1, p.309, 2000.
DOI : 10.1086/317805

M. Ikeda, M. Ohishi, and A. Nummelin, CHO toward Massive Star???forming Regions, The Astrophysical Journal, vol.560, issue.2, p.792, 2001.
DOI : 10.1086/322957

T. J. Millar, E. Herbst, and S. B. Charnley, The formation of oxygen-containing organic molecules in the Orion compact ridge, The Astrophysical Journal, vol.369, p.147, 1991.
DOI : 10.1086/169745

A. Mizuno, Y. Fukui, T. Iwata, S. Nozawa, and T. Takano, A remarkable multilobe molecular outflow - Rho Ophiuchi East, associated with IRAS 16293-2422, The Astrophysical Journal, vol.356, p.184, 1990.
DOI : 10.1086/168829

L. G. Mundy, A. Wootten, B. A. Wilking, G. A. Blake, and A. I. Sargent, IRAS 16293 - 2422 - A very young binary system?, The Astrophysical Journal, vol.385, p.306, 1992.
DOI : 10.1086/170939

M. A. Requena-torres, J. Martin-pintado, S. Martin, and M. R. Morris, The Galactic Center: The Largest Oxygen???bearing Organic Molecule Repository, The Astrophysical Journal, vol.672, issue.1, p.352, 2008.
DOI : 10.1086/523627

M. A. Requena-torres, J. Martin-pintado, and A. Rodriguez-franco, Organic molecules in the Galactic center, Astronomy & Astrophysics, vol.455, issue.3, p.971, 2006.
DOI : 10.1051/0004-6361:20065190
URL : https://hal.archives-ouvertes.fr/hal-00109388

G. R. Adande, N. J. Woolf, and L. M. Ziurys, Observations of Interstellar Formamide: Availability of a Prebiotic Precursor in the Galactic Habitable Zone, Astrobiology, vol.13, issue.5, p.439, 2011.
DOI : 10.1089/ast.2012.0912

S. E. Bisschop, J. K. Jørgensen, E. F. Van-dishoeck, and E. B. De-wachter, Testing grain-surface chemistry in massive hot-core regions, Astronomy & Astrophysics, vol.465, issue.3, p.913, 2007.
DOI : 10.1051/0004-6361:20065963
URL : http://arxiv.org/abs/astro-ph/0702066

E. Caux, TIMASSS: the IRAS??16293-2422 millimeter and submillimeter spectral survey, Astronomy & Astrophysics, vol.532, p.23, 2011.
DOI : 10.1051/0004-6361/201015399
URL : https://hal.archives-ouvertes.fr/hal-00582331

R. Chini, D. Ward-thompson, J. M. Kirk, M. Nielbock, B. Reipurth et al., Mm/Submm images of Herbig-Haro energy sources and candidate protostars, Astronomy & Astrophysics, vol.369, issue.1, p.155, 2001.
DOI : 10.1051/0004-6361:20010097

. N. Crimier, C. Ceccarelli, B. Lefloch, and A. Faure, Physical structure and water line spectrum predictions of the intermediate mass protostar OMC2-FIR4, Astronomy & Astrophysics, vol.506, issue.3, p.1229, 2009.
DOI : 10.1051/0004-6361/200911651
URL : https://hal.archives-ouvertes.fr/hal-00479945

N. Crimier, Physical structure of the envelopes of intermediate-mass protostars, Astronomy and Astrophysics, vol.516, p.102, 2010.
DOI : 10.1051/0004-6361/200913499
URL : https://hal.archives-ouvertes.fr/hal-00631895

N. Crimier, C. Ceccarelli, S. Maret, S. Bottinelli, E. Caux et al., The solar type protostar IRAS16293-2422: new constraints on the physical structure, Astronomy and Astrophysics, vol.519, p.65, 2010.
DOI : 10.1051/0004-6361/200913112
URL : https://hal.archives-ouvertes.fr/hal-00631917

F. Daniel, , CN, HCN, and HNC isotopologues, Astronomy & Astrophysics, vol.560, p.3, 2013.
DOI : 10.1051/0004-6361/201321939

J. Elias, A study of the Taurus dark cloud complex, The Astrophysical Journal, vol.224, p.857, 1978.
DOI : 10.1086/156436

N. J. Evans, . Ii, J. M. Rawlings, Y. L. Shirley, and L. G. Mundy, Tracing the Mass during Low???Mass Star Formation. II. Modeling the Submillimeter Emission from Preprotostellar Cores, The Astrophysical Journal, vol.557, issue.1, p.193, 2001.
DOI : 10.1086/321639

R. T. Garrod, S. L. Weaver, and E. Herbst, Complex Chemistry in Star???forming Regions: An Expanded Gas???Grain Warm???up Chemical Model, The Astrophysical Journal, vol.682, issue.1, p.283, 2008.
DOI : 10.1086/588035
URL : http://arxiv.org/abs/0803.1214

S. Green, Collisional excitation of interstellar methyl cyanide, The Astrophysical Journal, vol.309, p.331, 1986.
DOI : 10.1086/164605

T. I. Hasegawa and E. Herbst, Three-phase chemical models of dense interstellar clouds: gas, dust particle mantles and dust particle surfaces, Monthly Notices of the Royal Astronomical Society, vol.263, issue.3, p.589, 1993.
DOI : 10.1093/mnras/263.3.589

B. M. Jones, C. J. Bennett, and R. I. Kaiser, NCHO) WITHIN INTERSTELLAR ICE ANALOGS, The Astrophysical Journal, vol.734, issue.2, p.78, 2011.
DOI : 10.1088/0004-637X/734/2/78

K. Jørgensen, F. L. Schöier, and E. F. Van-dishoeck, Physical structure and CO abundance of low-mass protostellar envelopes, Astronomy & Astrophysics, vol.389, issue.3, p.908, 2002.
DOI : 10.1051/0004-6361:20020681

L. Loinard, R. M. Torres, A. J. Mioduszewski, and L. F. Rodríguez, A Preliminary VLBA Distance to the Core of Ophiuchus, with an Accuracy of 4%, The Astrophysical Journal, vol.675, issue.1, p.29, 2008.
DOI : 10.1086/529548

L. W. Looney, L. G. Mundy, and W. J. Welch, Unveiling the Circumstellar Envelope and Disk: A Subarcsecond Survey of Circumstellar Structures, The Astrophysical Journal, vol.529, issue.1, p.477, 2000.
DOI : 10.1086/308239

H. Maezawa, Large-Scale Mapping Observations of the C [CSC][CLC]i[/CLC][/CSC] [TSUP]3[/TSUP][ITAL]P[/ITAL][TINF]1[/TINF]???[TSUP]3[/TSUP][ITAL]P[/ITAL][TINF]0[/TINF] Line toward Heiles Cloud 2 in the Taurus Dark Cloud, The Astrophysical Journal, vol.524, issue.2, p.129, 1999.
DOI : 10.1086/312316

N. Marcelino, J. Cernicharo, E. Roueff, M. Gerin, and R. Mauersberger, Deuterated Thioformaldehyde in the Barnard 1 Cloud, The Astrophysical Journal, vol.620, issue.1, p.308, 2005.
DOI : 10.1086/426934

N. Marcelino, J. Cernicharo, B. Tercero, and E. Roueff, DISCOVERY OF FULMINIC ACID, HCNO, IN DARK CLOUDS, The Astrophysical Journal, vol.690, issue.1, p.27, 2009.
DOI : 10.1088/0004-637X/690/1/L27

S. Maret, C. Ceccarelli, E. Caux, A. G. Tielens, and A. Castets, Water emission in NGC??1333???IRAS??4, Astronomy & Astrophysics, vol.395, issue.2, p.573, 2002.
DOI : 10.1051/0004-6361:20021334
URL : http://www.aanda.org/articles/aa/pdf/2002/44/aa2736.pdf

H. S. Müller, S. Thorwirth, D. A. Roth, and G. Winnewisser, The Cologne Database for Molecular Spectroscopy, CDMS, Astronomy & Astrophysics, vol.370, issue.3, p.49, 2001.
DOI : 10.1051/0004-6361:20010367

H. S. Müller, F. Schlöder, J. Stutzki, and G. Winnewisser, The Cologne Database for Molecular Spectroscopy, CDMS: a useful tool for astronomers and spectroscopists, Journal of Molecular Structure, vol.742, issue.1-3, p.215, 2005.
DOI : 10.1016/j.molstruc.2005.01.027

A. Nummelin, P. Bergman, Å. Hjalmarson, P. Friberg, W. M. Irvine et al., A Three???Position Spectral Line Survey of Sagittarius B2 between 218 and 263 GHz. II. Data Analysis, The Astrophysical Journal Supplement Series, vol.128, issue.1, p.213, 2000.
DOI : 10.1086/313376

R. H. Rubin, G. W. Swenson, . Jr, R. C. Benson, H. L. Tigelaar et al., Microwave Detection of Interstellar Formamide, The Astrophysical Journal, vol.169, p.39, 1971.
DOI : 10.1086/180810
URL : http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1971ApJ...169L..39R&link_type=ARTICLE&db_key=AST&high=

R. Saladino, G. Botta, S. Pino, G. Costanzo, D. Mauro et al., Genetics first or metabolism first? The formamide clue, Chemical Society Reviews, vol.49, issue.2, p.5526, 2012.
DOI : 10.1002/anie.201004263
URL : https://hal.archives-ouvertes.fr/pasteur-00961554

F. L. Schöier, F. F. Van-der-tak, E. F. Van-dishoeck, and J. H. Black, An atomic and molecular database for analysis of submillimetre line observations, Astronomy & Astrophysics, vol.432, issue.1, p.369, 2005.
DOI : 10.1051/0004-6361:20041729

Y. L. Shirley, N. J. Evans, . Ii, J. M. Rawlings, and E. M. Gregersen, Tracing the Mass during Low???Mass Star Formation. I. Submillimeter Continuum Observations, The Astrophysical Journal Supplement Series, vol.131, issue.1, p.249, 2000.
DOI : 10.1086/317358

L. V. Tóth, M. Haas, D. Lemke, K. Mattila, and T. Onishi, Very cold cores in the Taurus Molecular Ring as seen by ISO, Astronomy & Astrophysics, vol.420, issue.2, p.533, 2004.
DOI : 10.1051/0004-6361:20035611

G. Adande, N. Woolf, and L. Ziurys, Observations of Interstellar Formamide: Availability of a Prebiotic Precursor in the Galactic Habitable Zone, Astrobiology, vol.13, issue.5, p.439, 2011.
DOI : 10.1089/ast.2012.0912

R. Aladro, J. Martín-pintado, S. Martín, R. Mauersberger, and E. Bayet, CCH multi-line analyses toward starburst galaxies, Astronomy & Astrophysics, vol.525, p.89, 2011.
DOI : 10.1051/0004-6361/201014090

P. Andre and T. Montmerle, From T Tauri stars to protostars: Circumstellar material and young stellar objects in the rho Ophiuchi cloud, The Astrophysical Journal, vol.420, p.837, 1994.
DOI : 10.1086/173608

R. Bachiller and M. Pérez-gutiérrez, Shock Chemistry in the Young Bipolar Outflow L1157, The Astrophysical Journal, vol.487, issue.1, p.93, 1997.
DOI : 10.1086/310877

A. Bacmann, E. Caux, and P. Hily-blant, First detection of ND in the solar-mass protostar IRAS16293-2422, Astronomy and Astrophysics, vol.521, p.42, 2010.
DOI : 10.1051/0004-6361/201015102
URL : https://hal.archives-ouvertes.fr/hal-00631935

A. Bacmann, V. Taquet, A. Faure, C. Kahane, and C. Ceccarelli, Detection of complex organic molecules in a prestellar core: a new challenge for astrochemical models, Astronomy & Astrophysics, vol.541, p.12, 2012.
DOI : 10.1051/0004-6361/201219207

M. B. Bell, P. A. Feldman, and M. J. Travers, Detection of HC[TINF]11[/TINF]N in the Cold Dust Cloud TMC-1, The Astrophysical Journal, vol.483, issue.1, p.61, 1997.
DOI : 10.1086/310732

B. Abdallah, D. Najar, F. Jaidane, N. Dumouchel, F. Lique et al., Hyperfine excitation of HCN by H2 at low temperature, Monthly Notices of the Royal Astronomical Society, vol.419, issue.3, p.2441, 2012.
DOI : 10.1111/j.1365-2966.2011.19896.x

G. A. Blake, E. F. Van-dishoeck, D. J. Jansen, T. D. Groesbeck, and L. G. Mundy, Molecular abundances and low-mass star formation. 1: Si- and S-bearing species toward IRAS 16293-2422, The Astrophysical Journal, vol.428, p.680, 1994.
DOI : 10.1086/174278

P. Bodenheimer, Angular Momentum Evolution of Young Stars and Disks, Annual Review of Astronomy and Astrophysics, vol.33, issue.1, p.199, 1995.
DOI : 10.1146/annurev.aa.33.090195.001215

A. Brack, The Molecular Origins of Life: Assembling Pieces of the Puzzle, 1998.
DOI : 10.1017/CBO9780511626180

R. D. Brown, J. G. Crofts, and P. D. Godfrey, Discovery of interstellar methyl formate, The Astrophysical Journal, vol.197, p.29, 1975.
DOI : 10.1086/181769

C. Carrasco-gonzález, G. Anglada, L. F. Rodríguez, J. M. Torrelles, and M. Osorio, PROPER MOTIONS OF THERMAL RADIO SOURCES NEAR HH 7-11 IN THE NGC 1333 STAR-FORMING REGION, The Astronomical Journal, vol.136, issue.6, p.2238, 2008.
DOI : 10.1088/0004-6256/136/6/2238

P. Caselli and C. Ceccarelli, Our astrochemical heritage, The Astronomy and Astrophysics Review, vol.534, issue.8, p.56, 2012.
DOI : 10.1051/0004-6361/201116515
URL : http://arxiv.org/abs/1210.6368

P. Caselli, C. M. Walmsley, R. Terzieva, and E. Herbst, The Ionization Fraction in Dense Cloud Cores, The Astrophysical Journal, vol.499, issue.1, p.234, 1998.
DOI : 10.1086/305624

E. Caux, C. Kahane, and A. Castets, TIMASSS: the IRAS??16293-2422 millimeter and submillimeter spectral survey, Astronomy & Astrophysics, vol.532, p.23, 2011.
DOI : 10.1051/0004-6361/201015399
URL : https://hal.archives-ouvertes.fr/hal-00582331

S. Cazaux, A. G. Tielens, and C. Ceccarelli, The Hot Core around the Low-Mass Protostar IRAS 16293-2422: Scoundrels Rule!, The Astrophysical Journal, vol.593, issue.1, p.51, 2003.
DOI : 10.1086/378038
URL : http://iopscience.iop.org/article/10.1086/378038/pdf

C. Ceccarelli, C. Dominik, and A. López-sepulcre, FINDS EVIDENCE FOR STELLAR WIND PARTICLES IN A PROTOSTELLAR ENVELOPE: IS THIS WHAT HAPPENED TO THE YOUNG SUN?, The Astrophysical Journal, vol.790, issue.1, p.1, 2014.
DOI : 10.1088/2041-8205/790/1/L1

C. Ceccarelli, L. Loinard, and A. Castets, emission: The smoking gun of grain surface-chemistry, Astronomy & Astrophysics, vol.372, issue.3, p.998, 2001.
DOI : 10.1051/0004-6361:20010559

J. Cernicharo, N. Marcelino, and E. Roueff, O, TOWARD B1: DUST GRAIN AND GAS-PHASE CHEMISTRY IN COLD DARK CLOUDS, The Astrophysical Journal, vol.759, issue.2, p.43, 2012.
DOI : 10.1088/2041-8205/759/2/L43
URL : http://iopscience.iop.org/article/10.1088/2041-8205/759/2/L43/pdf

C. J. Chandler, C. L. Brogan, Y. L. Shirley, and L. Loinard, IRAS 16293???2422: Proper Motions, Jet Precession, the Hot Core, and the Unambiguous Detection of Infall, The Astrophysical Journal, vol.632, issue.1, p.371, 2005.
DOI : 10.1086/432828

S. B. Charnley, A. G. Tielens, and T. J. Millar, On the molecular complexity of the hot cores in Orion A - Grain surface chemistry as 'The last refuge of the scoundrel', The Astrophysical Journal, vol.399, p.71, 1992.
DOI : 10.1086/186609

A. C. Cheung, D. M. Rank, C. H. Townes, D. D. Thornton, and W. J. Welch, Molecules in the Interstellar Medium by Their Microwave Emission, Physical Review Letters, vol.3, issue.25, p.1701, 1968.
DOI : 10.1016/0019-1035(64)90051-X

R. Chini, D. Ward-thompson, and J. M. Kirk, Mm/Submm images of Herbig-Haro energy sources and candidate protostars, Astronomy & Astrophysics, vol.369, issue.1, p.155, 2001.
DOI : 10.1051/0004-6361:20010097

D. W. Clarke and J. P. Ferris, Photodissociation of Cyanoacetylene: Application to the Atmospheric Chemistry of Titan, Icarus, vol.115, issue.1, p.119, 1995.
DOI : 10.1006/icar.1995.1083

M. A. Cordiner, S. B. Charnley, E. S. Wirström, and R. G. Smith, ORGANIC CHEMISTRY OF LOW-MASS STAR-FORMING CORES. I. 7 mm SPECTROSCOPY OF CHAMAELEON MMS1, The Astrophysical Journal, vol.744, issue.2, p.131, 2012.
DOI : 10.1088/0004-637X/744/2/131

J. C. Correia, M. Griffin, and P. Saraceno, The circumstellar environment of IRAS 16293???2422, Astronomy & Astrophysics, vol.418, issue.2, p.607, 2004.
DOI : 10.1051/0004-6361:20040056

A. Coutens, J. K. Jørgensen, and M. H. Van-der-wiel, The ALMA-PILS survey: First detections of deuterated formamide and deuterated isocyanic acid in the interstellar medium, Astronomy & Astrophysics, vol.590, issue.553, pp.6-75, 2013.
DOI : 10.1051/0004-6361/201628612

N. Crimier, C. Ceccarelli, and T. Alonso-albi, Physical structure and water line spectrum predictions of the intermediate mass protostar OMC2-FIR4, Astronomy & Astrophysics, vol.506, issue.3, p.1229, 2009.
DOI : 10.1051/0004-6361/200911651
URL : https://hal.archives-ouvertes.fr/hal-00479945

N. Crimier, C. Ceccarelli, and S. Maret, The solar type protostar IRAS16293-2422: new constraints on the physical structure, Astronomy and Astrophysics, vol.519, issue.560, pp.65-68, 2010.
DOI : 10.1051/0004-6361/200913112
URL : https://hal.archives-ouvertes.fr/hal-00631917

S. D. Doty, F. L. Schöier, and E. F. Van-dishoeck, Physical-chemical modeling of the low-mass protostar IRAS??16293-2422, Astronomy & Astrophysics, vol.418, issue.3, p.1021, 2004.
DOI : 10.1051/0004-6361:20034476

A. E. Douglas and G. Herzberg, Note on CH^{+} in Interstellar Space and in the Laboratory., The Astrophysical Journal, vol.94, p.381, 1941.
DOI : 10.1086/144342

J. H. Elias, A study of the Taurus dark cloud complex, The Astrophysical Journal, vol.224, p.857, 1978.
DOI : 10.1086/156436

G. B. Esplugues, J. Cernicharo, and S. Viti, N, Astronomy & Astrophysics, vol.559, p.51, 2013.
DOI : 10.1051/0004-6361/201322073

I. Evans, N. J. Rawlings, J. M. Shirley, Y. L. Mundy, and L. G. , Tracing the Mass during Low???Mass Star Formation. II. Modeling the Submillimeter Emission from Preprotostellar Cores, The Astrophysical Journal, vol.557, issue.1, p.193, 2001.
DOI : 10.1086/321639

F. Fontani, C. Codella, and C. Ceccarelli, THE L1157-B1 ASTROCHEMICAL LABORATORY: MEASURING THE TRUE FORMALDEHYDE DEUTERATION ON GRAIN MANTLES, The Astrophysical Journal, vol.788, issue.2, pp.43-1513, 2014.
DOI : 10.1088/2041-8205/788/2/L43

E. Furlan, S. T. Megeath, and M. Osorio, ON THE NATURE OF THE DEEPLY EMBEDDED PROTOSTAR OMC-2 FIR 4, The Astrophysical Journal, vol.786, issue.1, p.26, 2014.
DOI : 10.1088/0004-637X/786/1/26

J. García-rojas and C. Esteban, Regions, The Astrophysical Journal, vol.670, issue.1, p.457, 2007.
DOI : 10.1086/521871

R. T. Garrod, W. Weaver, S. L. Herbst, and E. , Complex Chemistry in Star???forming Regions: An Expanded Gas???Grain Warm???up Chemical Model, The Astrophysical Journal, vol.682, issue.1, p.283, 2008.
DOI : 10.1086/588035
URL : http://arxiv.org/abs/0803.1214

I. Gatley, E. E. Becklin, and K. Mattews, A New Infrared Complex and Molecular Cloud in Orion, The Astrophysical Journal, vol.191, p.121, 1974.
DOI : 10.1086/181566

J. M. Girart, R. Estalella, A. Palau, J. M. Torrelles, and R. Rao, ON THE ORIGIN OF THE MOLECULAR OUTFLOWS IN IRAS 16293???2422, The Astrophysical Journal, vol.780, issue.1, p.11, 2014.
DOI : 10.1088/2041-8205/780/1/L11

D. T. Halfen, V. Ilyushin, and L. M. Ziurys, FORMATION OF PEPTIDE BONDS IN SPACE: A COMPREHENSIVE STUDY OF FORMAMIDE AND ACETAMIDE IN Sgr B2(N), The Astrophysical Journal, vol.743, issue.1, p.60, 2011.
DOI : 10.1088/0004-637X/743/1/60

P. Hily-blant, S. Maret, and A. Bacmann, Nitrogen hydrides in the cold envelope of IRAS??16293-2422, Astronomy and Astrophysics, vol.521, p.52, 2010.
DOI : 10.1051/0004-6361/201015253
URL : https://hal.archives-ouvertes.fr/hal-00515300

M. Ikeda, M. Ohishi, and A. Nummelin, CHO toward Massive Star???forming Regions, The Astrophysical Journal, vol.560, issue.2, p.792, 2001.
DOI : 10.1086/322957

K. B. Jefferts, A. A. Penzias, and R. W. Wilson, Deuterium in the Orion Nebula, The Astrophysical Journal, vol.179, p.57, 1973.
DOI : 10.1086/181116

B. M. Jones, C. J. Bennett, and R. I. Kaiser, NCHO) WITHIN INTERSTELLAR ICE ANALOGS, The Astrophysical Journal, vol.734, issue.2, p.78, 2011.
DOI : 10.1088/0004-637X/734/2/78

J. K. Jørgensen, T. L. Bourke, Q. Nguyen-luong, and S. Takakuwa, Arcsecond resolution images of the chemical structure of??the??low-mass protostar IRAS??16293-2422, Astronomy & Astrophysics, vol.534, p.100, 2011.
DOI : 10.1051/0004-6361/201117139

J. K. Jørgensen, C. Favre, and S. E. Bisschop, DETECTION OF THE SIMPLEST SUGAR, GLYCOLALDEHYDE, IN A SOLAR-TYPE PROTOSTAR WITH ALMA, The Astrophysical Journal, vol.757, issue.1, p.4, 2012.
DOI : 10.1088/2041-8205/757/1/L4

J. K. Jørgensen, D. Johnstone, E. F. Van-dishoeck, and S. D. Doty, The effect of a strong external radiation field on protostellar envelopes in Orion, Astronomy & Astrophysics, vol.449, issue.2, p.609, 2006.
DOI : 10.1051/0004-6361:20053011

J. K. Jørgensen, F. Lahuis, and F. L. Schöier, Observations of the Protostellar Binary IRAS 16293-2422, The Astrophysical Journal, vol.631, issue.1, p.77, 2005.
DOI : 10.1086/497003

J. K. Jørgensen, F. L. Schöier, and E. F. Van-dishoeck, Physical structure and CO abundance of low-mass protostellar envelopes, Astronomy & Astrophysics, vol.389, issue.3, p.908, 2002.
DOI : 10.1051/0004-6361:20020681

J. K. Jørgensen, F. L. Schöier, and E. F. Van-dishoeck, Molecular inventories and chemical evolution of low-mass protostellar envelopes, Astronomy & Astrophysics, vol.416, issue.2, p.603, 2004.
DOI : 10.1051/0004-6361:20034440

C. Kahane, C. Ceccarelli, A. Faure, and E. Caux, DETECTION OF FORMAMIDE, THE SIMPLEST BUT CRUCIAL AMIDE, IN A SOLAR-TYPE PROTOSTAR, The Astrophysical Journal, vol.763, issue.2, p.38, 2013.
DOI : 10.1088/2041-8205/763/2/L38

M. M. Kama, C. Dominik, and S. Maret, /HIFI, Astronomy and Astrophysics, vol.521, p.39, 2010.
DOI : 10.1051/0004-6361/201015118
URL : https://hal.archives-ouvertes.fr/hal-00664361

M. Kama, A. López-sepulcre, and C. Dominik, /HIFI spectral survey of OMC-2 FIR 4 (CHESS), Astronomy & Astrophysics, vol.556, p.57, 2013.
DOI : 10.1051/0004-6361/201219431
URL : https://www.aanda.org/articles/aa/pdf/2013/08/aa19431-12.pdf

L. E. Kristensen, P. D. Klaassen, J. C. Mottram, and M. Schmalzl, = 6???5 observations of IRAS 16293???2422, Astronomy & Astrophysics, vol.549, p.6, 2013.
DOI : 10.1051/0004-6361/201220668

L. E. Kristensen, E. F. Van-dishoeck, and E. A. Bergin, (WISH), Astronomy & Astrophysics, vol.542, p.8, 2012.
DOI : 10.1051/0004-6361/201118146
URL : https://hal.archives-ouvertes.fr/hal-00633381

C. J. Lada and B. A. Wilking, The nature of the embedded population in the Rho Ophiuchi dark cloud - Mid-infrared observations, The Astrophysical Journal, vol.287, p.610, 1984.
DOI : 10.1086/162719

J. L. Linsky, B. T. Draine, and H. W. Moos, What Is the Total Deuterium Abundance in the Local Galactic Disk?, The Astrophysical Journal, vol.647, issue.2, p.1106, 2006.
DOI : 10.1086/505556
URL : https://hal.archives-ouvertes.fr/hal-00129178

D. C. Lis, E. Roueff, and M. Gerin, Detection of Triply Deuterated Ammonia in the Barnard 1 Cloud, The Astrophysical Journal, vol.571, issue.1, p.55, 2002.
DOI : 10.1086/341132

A. López-sepulcre, V. Taquet, and Á. Sánchez-monge, High-angular resolution observations towards OMC-2 FIR 4: Dissecting an intermediate-mass protocluster, Astronomy & Astrophysics, vol.556, p.62, 2013.
DOI : 10.1051/0004-6361/201220905

. Lunine, Titan as an analog of Earth???s past and future, The European Physical Journal Conferences, vol.1, p.267, 2009.
DOI : 10.1140/epjconf/e2009-00926-7

M. N. Machida, S. Inutsuka, and T. Matsumoto, High??? and Low???Velocity Magnetized Outflows in the Star Formation Process in a Gravitationally Collapsing Cloud, The Astrophysical Journal, vol.676, issue.2, p.1088, 2008.
DOI : 10.1086/528364

A. Maeda, F. C. De-lucia, and E. Herbst, Submillimeter-wave spectra of H12COOCH3 and H13COOCH3 in excited CH3 torsional states, Journal of Molecular Spectroscopy, vol.251, issue.1-2, p.293, 2008.
DOI : 10.1016/j.jms.2008.03.014

H. Maezawa, M. Ikeda, and T. Ito, Large-Scale Mapping Observations of the C [CSC][CLC]i[/CLC][/CSC] [TSUP]3[/TSUP][ITAL]P[/ITAL][TINF]1[/TINF]???[TSUP]3[/TSUP][ITAL]P[/ITAL][TINF]0[/TINF] Line toward Heiles Cloud 2 in the Taurus Dark Cloud, The Astrophysical Journal, vol.524, issue.2, p.129, 1999.
DOI : 10.1086/312316

P. Manoj, D. M. Watson, and D. A. Neufeld, /PACS SPECTROSCOPIC SURVEY OF PROTOSTARS IN ORION: THE ORIGIN OF FAR-INFRARED CO EMISSION, The Astrophysical Journal, vol.763, issue.2, p.83, 2013.
DOI : 10.1088/0004-637X/763/2/83

N. Marcelino, J. Cernicharo, B. Tercero, and E. Roueff, DISCOVERY OF FULMINIC ACID, HCNO, IN DARK CLOUDS, The Astrophysical Journal, vol.690, issue.1, p.27, 2009.
DOI : 10.1088/0004-637X/690/1/L27

A. Marenich and J. Boggs, Coupled Cluster CCSD(T) Calculations of Equilibrium Geometries, Anharmonic Force Fields, and Thermodynamic Properties of the Formyl (HCO) and Isoformyl (COH) Radical Species, The Journal of Physical Chemistry A, vol.107, issue.13, p.2343, 2003.
DOI : 10.1021/jp0223298

O. Miettinen, A MALT90 study of the chemical properties of massive clumps and filaments of infrared dark clouds, Astronomy & Astrophysics, vol.562, p.3, 2014.
DOI : 10.1051/0004-6361/201322596

T. J. Millar, E. Herbst, and S. B. Charnley, The formation of oxygen-containing organic molecules in the Orion compact ridge, The Astrophysical Journal, vol.369, p.147, 1991.
DOI : 10.1086/169745

M. J. Mumma and S. B. Charnley, The Chemical Composition of Comets???Emerging Taxonomies and Natal Heritage, Annual Review of Astronomy and Astrophysics, vol.49, issue.1, p.471, 2011.
DOI : 10.1146/annurev-astro-081309-130811

L. G. Mundy, A. Wootten, B. A. Wilking, G. A. Blake, and A. I. Sargent, IRAS 16293 - 2422 - A very young binary system?, The Astrophysical Journal, vol.385, p.306, 1992.
DOI : 10.1086/170939

A. Nummelin, P. Bergman, and Å. Hjalmarson, A Three???Position Spectral Line Survey of Sagittarius B2 between 218 and 263 GHz. II. Data Analysis, The Astrophysical Journal Supplement Series, vol.128, issue.1, p.213, 2000.
DOI : 10.1086/313376

K. I. Öberg, S. Bottinelli, J. K. Jørgensen, and E. F. Van-dishoeck, A COLD COMPLEX CHEMISTRY TOWARD THE LOW-MASS PROTOSTAR B1-b: EVIDENCE FOR COMPLEX MOLECULE PRODUCTION IN ICES, The Astrophysical Journal, vol.716, issue.1, p.825, 2010.
DOI : 10.1088/0004-637X/716/1/825

B. Parise, P. Bergman, and K. Menten, Characterizing the chemical pathways for water formation ??? a deep search for hydrogen peroxide, Faraday Discuss., vol.315, p.349, 2014.
DOI : 10.1086/422828

B. Parise, A. Castets, and E. Herbst, First detection of triply-deuterated methanol, Astronomy & Astrophysics, vol.416, issue.1, p.159, 2004.
DOI : 10.1051/0004-6361:20034490
URL : https://hal.archives-ouvertes.fr/hal-00000808

B. Parise, F. Du, and F. Liu, Detection of OD towards the low-mass protostar IRAS 16293???2422, Astronomy & Astrophysics, vol.542, p.5, 2012.
DOI : 10.1051/0004-6361/201218784

J. E. Pineda, A. J. Maury, and G. A. Fuller, The first ALMA view of IRAS??16293-2422, Astronomy & Astrophysics, vol.544, p.7, 2012.
DOI : 10.1051/0004-6361/201219589

S. Raunier, T. Chiavassa, and F. Duvernay, Tentative identification of urea and formamide in ISO-SWS infrared spectra of interstellar ices, Astronomy & Astrophysics, vol.416, issue.1, p.165, 2004.
DOI : 10.1051/0004-6361:20034558
URL : https://hal.archives-ouvertes.fr/hal-00367617

B. Reipurth, L. F. Rodríguez, and R. Chini, VLA Detection of Protostars in OMC-2/3, The Astronomical Journal, vol.118, issue.2, p.983, 1999.
DOI : 10.1086/300958

R. H. Rubin, J. Swenson, G. W. Benson, R. C. Tigelaar, H. L. Flygare et al., Microwave Detection of Interstellar Formamide, The Astrophysical Journal, vol.169, p.39, 1971.
DOI : 10.1086/180810
URL : http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1971ApJ...169L..39R&link_type=ARTICLE&db_key=AST&high=

N. Sakai, T. Sakai, T. Hirota, and S. Yamamoto, Abundant Carbon???Chain Molecules toward the Low???Mass Protostar IRAS 04368+2557 in L1527, The Astrophysical Journal, vol.672, issue.1, p.371, 2008.
DOI : 10.1086/523635

F. L. Schöier, J. K. Jørgensen, E. F. Van-dishoeck, and G. A. Blake, Does IRAS 16293???2422 have a hot core? Chemical inventory and abundance changes in its protostellar environment, Astronomy & Astrophysics, vol.390, issue.3, p.1001, 2002.
DOI : 10.1051/0004-6361:20020756

F. L. Schöier, J. K. Jørgensen, E. F. Van-dishoeck, and G. A. Blake, On the origin of H$_\mathsf{2}$CO abundance enhancements in low-mass protostars, Astronomy & Astrophysics, vol.418, issue.1, p.185, 2004.
DOI : 10.1051/0004-6361:20035769

Y. Shimajiri, T. Sakai, and Y. Kitamura, SPECTRAL-LINE SURVEY AT MILLIMETER AND SUBMILLIMETER WAVELENGTHS TOWARD AN OUTFLOW-SHOCKED REGION, OMC 2-FIR 4, The Astrophysical Journal Supplement Series, vol.221, issue.2, p.31, 2015.
DOI : 10.1088/0067-0049/221/2/31
URL : http://iopscience.iop.org/article/10.1088/0067-0049/221/2/31/pdf

Y. Shimajiri, S. Takahashi, S. Takakuwa, M. Saito, and R. Kawabe, Millimeter??? and Submillimeter???Wave Observations of the OMC???2/3 Region. II. Observational Evidence for Outflow???triggered Star Formation in the OMC???2 FIR 3/4 Region, The Astrophysical Journal, vol.683, issue.1, p.255, 2008.
DOI : 10.1086/588629

Y. L. Shirley, I. Evans, N. J. Rawlings, J. M. Gregersen, and E. M. , Tracing the Mass during Low???Mass Star Formation. I. Submillimeter Continuum Observations, The Astrophysical Journal Supplement Series, vol.131, issue.1, p.249, 2000.
DOI : 10.1086/317358

F. H. Shu, Self-similar collapse of isothermal spheres and star formation, The Astrophysical Journal, vol.214, p.488, 1977.
DOI : 10.1086/155274
URL : http://doi.org/10.1086/155274

R. L. Snell, F. P. Schloerb, J. S. Young, A. Hjalmarson, and P. Friberg, Observations of HC3N, HC5N, and HC7N in molecular clouds, The Astrophysical Journal, vol.244, p.45, 1981.
DOI : 10.1086/158683

P. M. Solomon, K. B. Jefferts, A. A. Penzias, and R. W. Wilson, Detection of Millimeter Emission Lines from Interstellar Methyl Cyanide, The Astrophysical Journal, vol.168, p.107, 1971.
DOI : 10.1086/180794
URL : http://doi.org/10.1086/180794

R. Stark, G. Sandell, and S. C. Beck, Probing the Early Stages of Low???Mass Star Formation in LDN 1689N: Dust and Water in IRAS 16293???2422A, B, and E, The Astrophysical Journal, vol.608, issue.1, p.341, 2004.
DOI : 10.1086/392492

H. Suzuki, S. Yamamoto, and M. Ohishi, A survey of CCS, HC3N, HC5N, and NH3 toward dark cloud cores and their production chemistry, The Astrophysical Journal, vol.392, p.551, 1992.
DOI : 10.1086/171456

P. Swings and L. Rosenfeld, Considerations Regarding Interstellar Molecules, The Astrophysical Journal, vol.86, p.483, 1937.
DOI : 10.1086/143880
URL : http://doi.org/10.1086/143880

V. Taquet, C. Ceccarelli, and C. Kahane, Multilayer modeling of porous grain surface chemistry, Astronomy & Astrophysics, vol.538, p.42, 2012.
DOI : 10.1051/0004-6361/201117802

V. Taquet, A. López-sepulcre, and C. Ceccarelli, CONSTRAINING THE ABUNDANCES OF COMPLEX ORGANICS IN THE INNER REGIONS OF SOLAR-TYPE PROTOSTARS, The Astrophysical Journal, vol.804, issue.2, p.81, 2015.
DOI : 10.1088/0004-637X/804/2/81

J. Thronson, H. A. Harper, D. A. Keene, and J. , Observations of five moderate-luminosity far-infrared sources in Orion and Monoceros, The Astronomical Journal, vol.83, p.492, 1978.
DOI : 10.1086/112228

A. Tielens, The Physics and Chemistry of the Interstellar Medium, 2005.
DOI : 10.1017/CBO9780511819056

B. E. Turner, E. F. Van-dishoeck, G. A. Blake, B. T. Draine, and J. I. Lunine, Detection of doubly deuterated interstellar formaldehyde (D2CO) - an indicator of active grain surface chemistry, Protostars and Planets III, pp.29-163, 1990.
DOI : 10.1086/185840

E. F. Van-dishoeck, G. A. Blake, D. J. Jansen, and T. D. Groesbeck, Molecular Abundances and Low-Mass Star Formation. II. Organic and Deuterated Species toward IRAS 16293-2422, The Astrophysical Journal, vol.447, p.760, 1995.
DOI : 10.1086/175915

C. K. Walker, C. J. Lada, E. T. Young, P. R. Maloney, and B. A. Wilking, Spectroscopic evidence for infall around an extraordinary IRAS source in Ophiuchus, The Astrophysical Journal, vol.309, p.47, 1986.
DOI : 10.1086/184758

N. Watanabe and A. Kouchi, Efficient Formation of Formaldehyde and Methanol by the Addition of Hydrogen Atoms to CO in H[TINF]2[/TINF]O-CO Ice at 10 K, The Astrophysical Journal, vol.571, issue.2, p.173, 2002.
DOI : 10.1086/341412

M. Wernli, L. Wiesenfeld, A. Faure, and P. Valiron, and He at low temperatures, Astronomy & Astrophysics, vol.464, issue.3, p.1147, 2007.
DOI : 10.1051/0004-6361:20066112
URL : https://hal.archives-ouvertes.fr/hal-00116656

N. Winstanley and L. A. Nejad, Cyanopolyyne chemistry in TMC-1, Astrophysics and Space Science, vol.244, issue.1, p.13, 1996.
DOI : 10.1007/BF00640193

L. A. Zapata, L. Loinard, and L. F. Rodríguez, ALMA 690 GHz OBSERVATIONS OF IRAS 16293???2422B: INFALL IN A HIGHLY OPTICALLY THICK DISK, The Astrophysical Journal, vol.764, issue.1, p.14, 2013.
DOI : 10.1088/2041-8205/764/1/L14