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Contributions à la modélisation multi-échelles de la réponse immunitaire T-CD8 : construction, analyse, simulation et calibration de modèles

Loïc Barbarroux 1, 2
2 DRACULA - Multi-scale modelling of cell dynamics : application to hematopoiesis
CGPhiMC - Centre de génétique et de physiologie moléculaire et cellulaire, Inria Grenoble - Rhône-Alpes, ICJ - Institut Camille Jordan [Villeurbanne]
Abstract : Upon infection by an intracellular pathogen, the organism triggers a specific immune response,mainly driven by the CD8 T cells. These cells are responsible for the eradication of this type of infections and the constitution of the immune repertoire of the individual. The immune response is constituted by many processes which act over several interconnected physical scales (intracellular scale, single cell scale, cell population scale). This biological phenomenon is therefore a complex process, for which it is difficult to observe or measure the links between the different processes involved. We propose three multiscale mathematical models of the CD8 immune response, built with different formalisms but related by the same idea : to make the behavior of the CD8 T cells depend on their intracellular content. For each model, we present, if possible, its construction process based on selected biological hypothesis, its mathematical study and its ability to reproduce the immune response using numerical simulations. The models we propose succesfully reproduce qualitatively and quantitatively the CD8 immune response and thus constitute useful tools to further investigate this biological phenomenon.
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Loïc Barbarroux. Contributions à la modélisation multi-échelles de la réponse immunitaire T-CD8 : construction, analyse, simulation et calibration de modèles. Autre. Université de Lyon, 2017. Français. ⟨NNT : 2017LYSEC026⟩. ⟨tel-01569442v2⟩

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