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Theses

Phénotypes biologiques de l'angioedème à kinine

Abstract : Kinin mediated angioedema (AO) is characterized by spontaneous and recurrent oedema affecting subcutaneous and submucosal tissue. Oedemas develop subsequently to kinin accumulation on vascular endothelium. AO severity is depending on localisation, they are warping on subcutaneous tissue, painful on digestive mucous and life treating when affected the larynx. Kinin mediated AO was first associated with C1 Inhibitor (C1Inh) deficiency and thereafter AO without C1Inh deficiency has been described. AO is a multifactorial disease for which all the decision-making factor(s) is(are) not yet identified. As results of this work, have emerged (1) a characterization of strategic parameters of the kinin production for AO, (2) an identification of significant and decision-making parameters for the attack onset and severity, (3) a cover of biological phenotypes of the AO patients
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Delphine Charignon. Phénotypes biologiques de l'angioedème à kinine. Médecine humaine et pathologie. Université de Grenoble, 2014. Français. ⟨NNT : 2014GRENV042⟩. ⟨tel-01558861⟩

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