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Epidemiologia de la epilepsia en el Peru : Neurocisticercosis como causa de epilepsia secundaria en la region norte del Peru

Abstract : Backgrounds. Neurocysticercosis is a parasitic infection of the brain and a common cause of epilepsy in poor regions. There are scarce community-based studies about its comorbidities as epilepsy and neurocysticercosis. Methods. In the northern region of Peru, we performed three community based-studies and one systematic review a) to assess the prevalence of asymptomatic NCC, b) the prevalence of epilepsy and epileptic seizures and NCC c) seroprevalence of cysticercosis (EITB-LLGP) and d) to perform a community intervention to interrupt the Taenia solium transmission. Results. Of the 256 residents who underwent CT scan, 48 (18.8%) had brain calcifications consistent with NCC. Lifetime prevalence of epilepsy was 17.25/1000, the proportion of NCC in people with epilepsy was 39% (109/282), and the seroprevalence of EITB-LLGP in individuals with epilepsy was 40% and between 23.4 to 36.9% in the general population. The association between CC and epilepsy had a OR of 2.7 (95% CI 2.1-3.6, p <0.001). Three rounds of mass treatment with niclosamida in humans and mass treatment and vaccination in pigs was implemented in 107 rural communities (n=81,170 people). No infected pigs with cysticercosis were found in 105 of 107 communities. Conclusion. NCC is a strong contributor of epilepsy and epileptic seizures. We showed that transmission of Taenia solium infection was interrupted on a regional scale in endemic regions in Peru
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Luz Maria Moyano. Epidemiologia de la epilepsia en el Peru : Neurocisticercosis como causa de epilepsia secundaria en la region norte del Peru. Human health and pathology. Université de Limoges, 2016. Español. ⟨NNT : 2016LIMO0135⟩. ⟨tel-01544029⟩

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