Évaluation de l’efficacité de dégradation et de décontamination cutanée du CeO2 vis-à-vis d’un composé organophosphoré, le Paraoxon

Abstract : The organophosphorus nerve agents form part of chemical agents which pose the NRBC threat (nuclear, radio, biological, chemical). These agents can get into the body by inhalation, ingestion or skin absorption. The main route of chemical agent absorption which are low volatile, as VX or yperite, is the dermal route. Decontamination of unprotected skin areas is crucial to prevent excessive absorption of toxic. This work aimed at evaluating the ability of cerium oxide nanoparticles to adsorb and degrade organophosphorus compounds by using an organophosphorus pesticide, Paraoxon, and an in vitro model, pig-ear skin. The results showed that ceria, in powder form, degraded the Paraoxon but did not allow reducing its absorption through the skin. Liquid forms containing ceria (aqueous suspension, Pickering emulsion) have been formulated in order to avoid the dispersion of particles in the air during its use. While liquid formulations allow more efficient removal of Paraoxon during decontamin ation process, the degradation activity of ceria was low. The influence of the synthesis conditions on the physicochemical properties of ceria linked to degradation efficiency of nanoparticles has been studied. The results showed that specific surface area is the key parameter and that the application protocol of decontaminants must be adapted
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Alicia Salerno. Évaluation de l’efficacité de dégradation et de décontamination cutanée du CeO2 vis-à-vis d’un composé organophosphoré, le Paraoxon. Biotechnologie. Université de Lyon, 2016. Français. ⟨NNT : 2016LYSE1145⟩. ⟨tel-01541051⟩

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