, 39 II.3.2) Mécanismes médiés par les lymphocytes 40 II.3.2.1) Inhibition des réponses anti-tumorales 40 II.3.2.2) Rôles de l'IL-17 41 a) Impact sur l'angiogenèse, 41 b), p.42
, 46 III.1. NOS2, une synthétase inductible de l'oxyde nitrique (NO), p.46
, 46 III.1.1.1), III.1.1), p.47
, 48 III.1.2.1) Actions directes 49 a) Action sur les protéines, III.1.2) Mécanismes d'action......... 49 b) Action sur les lipides et les acides nucléiques, p.50
, 50 III.1.3.1) Cytokines et produits bactériens, p.52
, 52 III.2.1) Fonctions de NOS2 dans les cellules myéloïdes 52 III.2.1.2) Suppression des réponses immunitaires dans le contexte tumoral, ., p.53
, 54 III.2.2.1) Effets du NO exogène 54 a) Inhibition de la prolifération, p.54
, 57 III.3.1) Effets du NO sur la transformation cellulaire néoplasique 57 III.3.2) Effets du NO sur la croissance tumorale et la dissémination métastatique, III.3. Effets ambivalents du NO dérivé de NOS2 dans le cancer, p.58
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, 6.7) Abs were obtained from BioXCell Purified anti- Gr1 (RB6-8C5) and anti-NK1.1 (PK136) Abs were purified from hybridoma supernatants using a G protein-coupled Sephadex bead column. Mice were injected intraperitoneally twice a week with either 200 ?go fA b so r4 0 0n g of CCL2 (PeproTech), NAC was obtained from Sigma-Aldrich. Mice received 1 mg/mL NAC in drinking water from birth
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, Cervical LNs and spleen cells were incubated on ice for 20 min with a mixture of anti-CD8 (53-6.7), anti-CD11b (Mac-1), and anti-CD19 (1D3) Abs, obtained from hybridoma supernatants, and then with magnetic beads coupled to anti-rat immunoglobulins (Dynal Biotech)
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