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Facteurs influençant les valeurs du TBS chez des jeunes adultes sains et des femmes ménopausées avec ou sans antécédents de fractures ostéoporiques

Abstract : The aims of this thesis were to define the determinants of TBS in young adults and postmenopausal women and to verify whether TBS is associated with osteoporotic fractures in postmenopausal women and in obese postmenopausal women. Study 1a included 26 young women and showed that maximal oxygen consumption and muscular power level of the lower limbs are positively correlated to TBS (r values between 0.37 and 0.63). Study 1b included 56 young women 14 of which were overweight ; this study suggests that being overweight is not associated with higher TBS values. The only positive determinant of TBS in study 1b was VO₂ max. Study 1c included 67 young men 32 of which were overweight, and 12 were obese ; this study suggests that obesity and overweight do not positively influence TBS values. Study 1c shows that body weight and fat mass percentage are negatively correlated to TBS (r = -0.28 and r = -0.38 respectively). Study 2a included 1000 postmenopausal women 164 of which have presented a previous osteoporic fracture ; this study suggests that TBS is associated with previous osteoporotic fractures. Study 2 a suggests that in postmenopausal women, lumbar spine BMD is positively correlated to TBS while age is negatively correlated to TBS. Study 2b included 300 obese postmenopausal women 40 of which have presented a previous osteoporotic fracture ; this study suggests that TBS is not associated with previous osteoporotic fractures in this population contrary to lumbar spine BMD which is associated with previous osteoporotic fractures. Study 2b suggests therefore that TBS is not independant determinant of osteoporotic fractures in obese postmenopausal women.
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Marie-Louise Ayoub. Facteurs influençant les valeurs du TBS chez des jeunes adultes sains et des femmes ménopausées avec ou sans antécédents de fractures ostéoporiques. Santé publique et épidémiologie. Université du Littoral Côte d'Opale, 2016. Français. ⟨NNT : 2016DUNK0429⟩. ⟨tel-01526174⟩

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