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Contribution à la radiothérapie adaptative par analyse systématique de la fluence en entrée et de la dose en sortie du patient

Abstract : Modern radiation therapy combines complex techniques and personalized treatments, with the risk that certain evolutions and errors occurring during the course of the treatment might go unnoticed. These fluctuations may cause great damage to the health of the patient. In this perspective, we worked on the potential of a transit in vivo dosimetry system for continuous monitoring of the patient and, hereafter, adaptive radiotherapy. Our clinical experience and feasibility testing determined the main lines of work : automatization and simplification of the results analysis method. The developments included the creation of a golden data library and a series of root cause analyzes, allowing us to strengthen the accuracy of the system, to enhance the automatization of the setup and to identify tracks for an efficient analysis of the results and for the creation of additional analytical tools to facilitate the monitoring and adaptation of the treatments in clinical routine.
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Sofia Celi. Contribution à la radiothérapie adaptative par analyse systématique de la fluence en entrée et de la dose en sortie du patient. Physique Médicale [physics.med-ph]. Université Paul Sabatier - Toulouse III, 2016. Français. ⟨NNT : 2016TOU30037⟩. ⟨tel-01488996⟩

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